Bioceramics in Tissue Engineering

Yang, Yunzhi; Kang, Yunqing; Sen, Milan; Park, Sang Won

doi:10.1007/978-3-7091-0385-2_7

Cited by 20 publications

(8 citation statements)

References 140 publications

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“…Although uniform porosity is the dominant trend in rigid scaffold fabrication, we and others have demonstrated that a scaffold with a pore size gradient could match the architecture of bones by combining a highly porous component that promotes host tissue ingrowth with a less porous component that provides load-bearing support to make an ideal construct for restoring the functionality of damaged bone. 69, 120 A porous design also allows for addition of cell-laden soft materials, which can facilitate and guide remodeling to produce new bone tissue with properties similar, or ideally, identical, to that of the host. In order to better mimic the properties of bone, a top-down approach could also be adopted, in which microstructures could be actually incorporated into the bone scaffold frame to facilitate osseous tissue remodeling and inclusion, ingrowth, or development of new vascular beds.…”

Section: Tissue Engineering Approaches For Vascularized Bone Repairmentioning

confidence: 99%

Vascularization in Bone Tissue Engineering Constructs

et al. 2015

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Vascularization of large bone grafts is one of the main challenges of bone tissue engineering (BTE), and has held back the clinical translation of engineered bone constructs for two decades so far. The ultimate goal of vascularized BTE constructs is to provide a bone environment rich in functional vascular networks to achieve efficient osseointegration and accelerate restoration of function after implantation. To attain both structural and vascular integration of the grafts, a large number of biomaterials, cells, and biological cues have been evaluated. This review will present biological considerations for bone function restoration, contemporary approaches for clinical salvage of large bone defects and their limitations, state-of-the-art research on the development of vascularized bone constructs, and perspectives on evaluating and implementing novel BTE grafts in clinical practice. Success will depend on achieving full graft integration at multiple hierarchical levels, both between the individual graft components as well as between the implanted constructs and their surrounding host tissues. The paradigm of vascularized tissue constructs could not only revolutionize the progress of bone tissue engineering, but could also be readily applied to other fields in regenerative medicine for the development of new innovative vascularized tissue designs.

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Section: Tissue Engineering Approaches For Vascularized Bone Repairmentioning

confidence: 99%

Vascularization in Bone Tissue Engineering Constructs

et al. 2015

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“…[1][2][3][4] Calcium phosphate bioceramics are osteoconductive and bioresorbable, but they are brittle in shear and tension. [10][11][12] Composites based on degradable polymers and bioceramics have therefore been developed to take advantage of the properties of these two classes of materials. [13][14][15][16][17] In particular, PCL and b-tricalcium phosphate (b-TCP) composites have attracted extensive attention due to their high biocompatibility, long-term degradation, appropriate mechanical performances, and osteoconductivity.…”

Section: Introductionmentioning

confidence: 99%

Effect of Electron Beam Sterilization on Three-Dimensional-Printed Polycaprolactone/Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering

Bruyas

Moeinzadeh

Kim

et al. 2019

Tissue Engineering Part A

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Three-dimensional printing of composite materials such as polycaprolactone/beta-tricalcium phosphate (PCL/b-TCP) enables the design and manufacturing of scaffolds with advanced geometries, along with improved physical and biological properties for large bone defect repair. Terminal sterilization of the scaffolds is inevitable for clinical applications. Electron beam (E-beam) is nontoxic, and can be used for sterilizing heatsensitive scaffolds by the use of high radiation dose in a short period of time. In this article, we assessed the influence of E-beam sterilization on the properties of 3D-printed PCL/b-TCP scaffolds, focusing on the key physical and biological properties for bone tissue engineering. More specifically, we characterized the effect of a single-dose E-beam sterilization (25 kGy, ISO 11137) on surface morphology, hydrophilicity, degradation, and mechanical properties of the scaffolds as well as in vitro biological responses. The results showed that Ebeam irradiation did not alter the surface properties of scaffolds. A 14% increase in initial mechanical stiffness and strength of the scaffolds was observed after E-beam treatment. In addition, the E-beam-treated scaffolds had 25% faster degradation. The PCL chains within the scaffolds had larger polydispersity after the E-beam irradiation that was indicative of a concurrent cross-linking and chain scission. Moreover, in vitro cell studies showed no influence of E-beam sterilization on viability, attachment, proliferation, and osteogenic differentiation of cells seeded on the PCL/b-TCP scaffolds.

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“…Most recently, Alumina toughened Zirconia (ATZ) has been introduced as a ceramic composite that can combine the main advantages of the single-phase ceramics. It shows improved mechanical properties when compared to the monolithic ceramics, with increased fracture toughness, wear resistance and lower hardness, thus being a ceramic that is more easily machined into a final shape [9][10][11]. Though, since ATZ is a bioinert ceramic it requires surface modifications to enhance its biological performance.…”

Section: Introductionmentioning

confidence: 99%

Femtosecond laser microstructuring of alumina toughened zirconia for surface functionalization of dental implants

Carvalho

Grenho

Fernandes

et al. 2020

Ceramics International

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The continuous need for high-performance implants that can withstand mechanical loads while promoting implant integration into bone has focused recent research on the surface modification of hard ceramics. Their properties of biocompatibility, high mechanical and fatigue resistance and aesthetic color have contributed to its succefull applications in dentistry. Alumina toughened Zirconia (ATZ) has been gaining attention as a material for dental implants applications due to its advanced mechanical properties and minimal degradation at body temperature. Still, in order to improve tissue response to this bioinert material, additional modifications are desirable. Improving the surface functionality of this ceramic could lead to enhanced implant-tissue interaction and subsequently, a successful implant integration. In this work, microtopographies were developed on the surface of Alumina toughened Zirconia using an ultrafast laser methodology, aiming at improving the cellular response to this ceramic. Microscale grooves and grid-like geometries were produced on ATZ ceramics by femtosecond laser ablation, with a pulse width of 150 fs, wavelength of 800 nm and repetition rate of 1 kHz. The variation of surface topography, roughness, chemistry and wettability with different laser processing parameters was examined. Cell-surface interactions were evaluated for 7 days on both microstructured surfaces and a non-treated control with pre-osteoblasts, MC3T3-E1 cells. Both surface topographies showed to improve cell response, with increased metabolic activity when compared to the untreated control and modulating cell morphology up to 7 days. The obtained results suggest that femtosecond laser texturing may be a suitable non-contact methodology for creating tunable micro-scale surface topography on ATZ ceramics to enhance the biological response.

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Bioceramics in Tissue Engineering

Cited by 20 publications

References 140 publications

Vascularization in Bone Tissue Engineering Constructs

Vascularization in Bone Tissue Engineering Constructs

Effect of Electron Beam Sterilization on Three-Dimensional-Printed Polycaprolactone/Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering

Femtosecond laser microstructuring of alumina toughened zirconia for surface functionalization of dental implants

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