Biochanin‐A has antidiabetic, antihyperlipidemic, antioxidant, and protective effects on diabetic nephropathy via suppression of TGF‐β1 and PAR‐2 genes expression in kidney tissues of STZ‐induced diabetic rats

Amri, Jamal; Alaee, Mona; Babaei, Rasool; Saberi, Zahra; Meshkani, Reza; Ghazavi, Ali; Akbari, Abolfazl; Salehi, Mitra

doi:10.1002/bab.2272

Cited by 15 publications

(12 citation statements)

References 35 publications

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“…This nicely matches the earlier reports that stated increased expression of PAR-2 in unilateral ureteral obstruction in mouse model (38) and in IgA nephropathy patients (39). Also, PAR-2 gene expression was found to be elevated in the kidney tissues of STZ-treated mice compared to normal rats (40). On the other side, pre-treatment of mice with DPSE or HM showed a significant decrease of PAR-2 compared to the Gen-treated group suggesting that the observed nephroprotective effect of both extracts might be mediated by inhibition of PAR-2.…”

Section: Discussionsupporting

confidence: 92%

Date palm seed extract and herbal mixture mitigate gentamicin-induced renal injury in mice: Role of Protease-activated receptors (PARs) and Retinoid X receptor alpha (RXR-α)

Sohaim

Mohammed

Amin

et al. 2022

J Herbmed Pharmacol

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Introduction: Gentamicin (Gen) causes renal toxicity by inhibiting protein synthesis in kidney cells, causing proximal tubule cell necrosis and renal failure. Herein, we examined the nephroprotective effect of date palm seed extract (DPSE) and one herbal mixture (HM; composed of Tribulus terrestris, Aerva lanata, Andrographis paniculata, and Raphanus sativus) against Gen-induced renal toxicity in mice with special reference to the possible role of retinoid X receptor alpha (RXR-α) and protease-activated receptor 2 (PAR-2) in this effect. Methods: Thirty-two male Balb/c mice divided randomly into four groups were either treated with saline, Gen (225 mg/kg/i.p., daily from day 3 to day 10), Gen (225 mg/kg i.p.) daily from day 3 to day 10 and DPSE (100 mg/kg/p.o.) daily for 10 days, or Gen (225 mg/kg i.p.) daily from day 3 to day 10 and HM (100 mg/kg/p.o., daily for 10 days). Mice were sacrificed 24 hours after the last dose administration, and kidney tissues were dissected out, weighed, and subjected to histological, immunofluorescence, and biochemical assays. Results: The Gen-induced renal toxicity group demonstrated a significant decrease in RXR-α and a significant increase in PAR-2 protein expression. Treatment with DPSE or HM significantly improved Gen-induced effects on serum creatinine, blood urea nitrogen (BUN), white blood cells (WBCs), platelets, RXR-α extracellular matrix deposition, and PAR-2. Conclusion: The present study stated the nephroprotective effects of DPSE and HM and revealed, for the first time, the involvement of retinoid receptors and PAR-2 in Gen-induced renal toxicity as well as in the protective effects of the two tested natural products.

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Section: Discussionsupporting

confidence: 92%

Date palm seed extract and herbal mixture mitigate gentamicin-induced renal injury in mice: Role of Protease-activated receptors (PARs) and Retinoid X receptor alpha (RXR-α)

Sohaim

Mohammed

Amin

et al. 2022

J Herbmed Pharmacol

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“…The inhibition of PAR-2 has been found to enhance autophagy while preventing inflammation and fibrosis [86]. Contrary to expectations, biochanin A mitigates diabetic nephropathy by downregulating the expression of the TGF-β1 and PAR-2 genes [65,81,82]. Among the numerous health benefits of isoflavones, biochanin A is widely recognized for its anti-inflammatory, antihyperlipidemic, antioxidant, and anticancer attributes by suppressing TGF-β1 and PAR-2 gene expression in kidney tissues of STZ-induced diabetic rats [80][81][82].…”

Section: Anti-diabetic Activitymentioning

confidence: 99%

“…Investigations conducted in laboratory settings as well as on living organisms have shown that myricitrin can mitigate oxidative stress by stimulating nuclear factor erythroid 2-related factor 2 (Nrf-2) and counteracting oxidative radicals effectively (Figure 4) [72,79]. Among the numerous health benefits of isoflavones, biochanin A is widely recognized for its anti-inflammatory, antihyperlipidemic, antioxidant, and anticancer attributes by suppressing TGF-β1 and PAR-2 gene expression in kidney tissues of STZ-induced diabetic rats [80][81][82]. In addition to its antioxidant properties, biochanin A appears to exert an anti-diabetic influence.…”

Section: Anti-diabetic Activitymentioning

confidence: 99%

Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy

El Oirdi

2024

Pharmaceuticals

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There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in a broad range of characteristics and biological effects. Polyphenols can be found in a variety of foods and drinks, including fruits, cereals, tea, and coffee. Studies both in vitro and in vivo, as well as clinical trials, have shown that they possess potent antioxidant activities, numerous therapeutic effects, and health advantages. Dietary polyphenols have demonstrated the potential to prevent many health problems, including obesity, atherosclerosis, high blood sugar, diabetes, hypertension, cancer, and neurological diseases. In this paper, the protective effects of polyphenols and the mechanisms behind them are investigated in detail, citing the most recent available literature. This review aims to provide a comprehensive overview of the current knowledge on the role of polyphenols in preventing and managing chronic diseases. The cited publications are derived from in vitro, in vivo, and human-based studies and clinical trials. A more complete understanding of these naturally occurring metabolites will pave the way for the development of novel polyphenol-rich diet and drug development programs. This, in turn, provides further evidence of their health benefits.

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“…Biochanin A could be a promising candidate for lowering the advancement of cardiomyopathy in people with type 2 diabetes (Oza and Kulkarni, 2022). A study designed to examine the diabetic and diabetic nephropathy effects on diabetic rats revealed that administering biochanin-A markedly reduced the expression of transforming growth factor-β1 (TGF-β1), protease-activated receptors 2 (PAR-2) genes, and fasting blood glucose (FBG) (Amri et al, 2021).…”

Section: Metabolic Disorders 221 Diabetesmentioning

confidence: 99%

Mechanisms behind the pharmacological application of biochanin-A: a review

et al. 2023

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This review was aimed at summarizing the cellular and molecular mechanisms behind the various pharmacological actions of biochanin-A. Many studies have been reported claiming its application in cancers, metabolic disorders, airway hyperresponsiveness, cardiac disorders, neurological disorders, etc. With regard to hormone-dependent cancers like breast, prostate, and other malignancies like pancreatic, colon, lung, osteosarcoma, glioma that has limited treatment options, biochanin-A revealed agreeable results in arresting cancer development. Biochanin-A has also shown therapeutic benefits when administered for neurological disorders, diabetes, hyperlipidaemia, and other chronic diseases/disorders. Isoflavones are considered phenomenal due to their high efficiency in modifying the physiological functions of the human body. Biochanin-A is one among the prominent isoflavones found in soy (glycine max), red clover (Trifolium pratense), and alfalfa sprouts, etc., with proven potency in modulating vital cellular mechanisms in various diseases. It has been popular for ages among menopausal women in controlling symptoms. In view of the multi-targeted functions of biochanin-A, it is essential to summarize it's mechanism of action in various disorders. The safety and efficacy of biochanin-A need to be established in clinical trials involving human subjects. Biochanin-A might be able to modify various systems of the human body like the cardiovascular system, CNS, respiratory system, etc. It has shown a remarkable effect on hormonal cancers and other cancers. Many types of research on biochanin-A, particularly in breast, lung, colon, prostate, and pancreatic cancers, have shown a positive impact. Through modulating oxidative stress, SIRT-1 expression, PPAR gamma receptors, and other multiple mechanisms biochanin-A produces anti-diabetic action. The diverse molecular mechanistic pathways involved in the pharmacological ability of biochanin-A indicate that it is a very promising molecule and can play a major impact in modifying several physiological functions.

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Biochanin‐A has antidiabetic, antihyperlipidemic, antioxidant, and protective effects on diabetic nephropathy via suppression of TGF‐β1 and PAR‐2 genes expression in kidney tissues of STZ‐induced diabetic rats

Cited by 15 publications

References 35 publications

Date palm seed extract and herbal mixture mitigate gentamicin-induced renal injury in mice: Role of Protease-activated receptors (PARs) and Retinoid X receptor alpha (RXR-α)

Date palm seed extract and herbal mixture mitigate gentamicin-induced renal injury in mice: Role of Protease-activated receptors (PARs) and Retinoid X receptor alpha (RXR-α)

Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy

Mechanisms behind the pharmacological application of biochanin-A: a review

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