Biochemical abnormalities of athletic horses

McKenzie, Erica C.

doi:10.1016/b978-0-7020-4771-8.00043-0

Cited by 2 publications

(2 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is no apparent tissue specificity for either AST isoenzyme and horses have a significantly greater cytosolic to mitochondrial enzyme ratio than other species [ 11 ]. Peak CK activity is expected within 4-6 hours after acute muscle injury, with a circulating plasma half-life of approximately 123 +/- 28 minutes [ 12 ]. Alternatively aspartate aminotransferase activity peaks in the blood approximately 12-24 hours after muscle or liver injury and has a half-life of approximately 7 to 10 days [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although a recent report has evaluated serum alcohol dehydrogenase as a useful clinical parameter in detecting intestinal strangulation in acute abdominal cases, and is routinely used to assess hepatic dysfunction in humans, this spectrophotometric analysis is not widely available to most practitioners and requires specific analyzer capability [ 24 ]. Another commonly evaluated non-specific enzyme, lactate dehydrogenase was not evaluated in the current study as it is not a component of our diagnostic profile and has a multitude of iso-enzymes which limit clinical application [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of plasma muscle enzyme activity as an indicator of lesion characteristics and prognosis in horses undergoing celiotomy for acute gastrointestinal pain

2014

View full text Add to dashboard Cite

BackgroundIn horses undergoing celiotomy for acute gastrointestinal pain, identification of variables correlating with lesion severity and location, and survival provide veterinarians and owners with information that aids in making informed decisions regarding appropriate treatment. Muscle enzyme activity is often increased in horses undergoing celiotomy for acute gastrointestinal pain and it is not known if muscle enzyme activity increase is specific to lesion type or impacts prognosis for survival. The objective of this study was to evaluate the relationship of pre-operative increase in muscle enzyme activities with intestinal lesion characteristics, specifically lesion location (large versus small intestine) and whether it was strangulating versus nonstrangulating, and case survival in horses undergoing celiotomy for acute gastrointestinal pain.MethodsRecords of 241 horses undergoing exploratory laparotomy for colic were reviewed retrospectively. Evaluation of preoperative plasma aspartate aminotransferase (AST), creatine kinase (CK), sorbitol dehydrogenase (SDH), and gamma-glutamyltransferase (GGT) activities, fibrinogen and glucose concentrations, and hematocrit (HCT) and their association with gastrointestinal lesion characteristics and survival was performed.ResultsPre-operative increase in plasma CK and AST activity, and HCT and decrease in plasma bilirubin concentration were significantly associated with presence of lesions resulting in intestinal ischemia. Increase in plasma CK activity and HCT were significantly associated with a decreased probability of survival to hospital discharge. Plasma GGT and SDH activity, and glucose and fibrinogen concentration were not significantly associated with survival or severity of disease in multivariate analysis.ConclusionsPlasma muscle enyzme activity may be useful as a prognostic indicator in equine colic cases. Given that increases in plasma CK and AST activity were significantly associated with nonsurvival and the presence of intestinal ischemia, preoperative increase in these enzyme activities could assist in identification of disease severity and prognosis of horses undergoing celiotomy for acute gastrointestinal pain. Further study is indicated to elucidate the etiology of increased muscle enzyme activity in horses with surgical colic disease observed in this preliminary study.

show abstract