1971
DOI: 10.1001/archneur.1971.00490050066006
|View full text |Cite
|
Sign up to set email alerts
|

Biochemical Alterations in the Anoxic-Ischemic Lesion of Rat Brain

Abstract: The combined effects of unilateral vascular oc-

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
13
0

Year Published

1973
1973
2011
2011

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 50 publications
(15 citation statements)
references
References 42 publications
2
13
0
Order By: Relevance
“…86 Early studies with the Levine model 60 '" suggest that edematous changes (increased water content) correlate closely with the degree of vascular injury and with histological necrosis. On the other hand, Clendenon et al 49 show that accumulation of fluid can be detected within 15 minutes, while trypan blue staining is barely detectable at six hours. After carbon perfusion, poor filling is apparent at one hour and grossly evident at three hours.…”
Section: Ratmentioning
confidence: 98%
“…86 Early studies with the Levine model 60 '" suggest that edematous changes (increased water content) correlate closely with the degree of vascular injury and with histological necrosis. On the other hand, Clendenon et al 49 show that accumulation of fluid can be detected within 15 minutes, while trypan blue staining is barely detectable at six hours. After carbon perfusion, poor filling is apparent at one hour and grossly evident at three hours.…”
Section: Ratmentioning
confidence: 98%
“…Persistent EEG and clinical abnormalities beyond one hour after anoxia were always associated with cerebral infarction. Histologically, lesions were quite variable, but were most frequent in the neocortex, striatum, and hippocampus, with sparing or less severe involvement of medial cortical portions as reported by Levine 2 and Clendenon et al 4 All animals which survived beyond 48 hours ultimately improved clinically to the point where the only persistent abnormality at the end of one month was absent tactile placing in the extremities contralateral to the infarct.…”
Section: Discussionmentioning
confidence: 69%
“…Using the same rat preparation as Levine, 2 Allen et al 3 and Clendenon et al 4 reported cerebral edema within 50 minutes after anoxia. Edema increased during the next 24 hours.…”
mentioning
confidence: 99%
“…Various kinds of animal model such as transient and chronic ischemia model have been developed to study the pathophysiology and the efficacy of various treatment modalities 6,11,26) . These types of ischemia model are showed the temporal changes of cerebral blood flow (CBF) and various degrees of infarctions that produce brain damage 12) .…”
Section: Introductionmentioning
confidence: 99%