Biochemical Alterations of the Tunica Albuginea in Impotence

Raviv, Gil; Vanegas, Juan Pablo; Pétein, Michel; Schulman, Claude; Danguy, André; Kiss, Róbert; Wespes, Eric

doi:10.1016/s0022-5347(01)64127-2

Cited by 8 publications

(12 citation statements)

References 19 publications

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“…In the tunica albuginea, the collagen bundles were described as disposed in an outer longitudinal and an inner circular layer [9,18,21,22]. This arrangement was also observed in the present work in fetuses at 28 WPC.…”

Section: Discussionsupporting

confidence: 87%

“…Different opinions exist concerning the role of the collagen fibers in the tunica albuginea. Possibly, the collagen bundles enable the tunica albuginea to withstand greater corporal pressure by preserving the normal corporal expansion and the veno-occlusive function during erection [9,10,21,22].…”

Section: Discussionmentioning

confidence: 99%

“…Raviv et al [9] studied potent and impotent patients and found alterations in the distribution and structure of collagen in the tunica albuginea of the impotent patients. They stated that an alteration in the distribution and structure of the various collagen types in the tunica albuginea of impotent patients may interfere with normal function and lead to impotence.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, sufficient elasticity and compliance of the cavernosal structures are required for tumescence and erection to occur [5]. Also, the tunica albuginea plays an important role in the erection mechanism because it contributes to penile extensibility, rigidity, compliance, and veno-occlusion [9,10].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Collagen and Elastic Fibers in the Penis of Human Fetuses at 28 Weeks Postconception

Bastos

Costa²,

Cardoso³

et al. 1999

Eur Urol

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Collagen and Elastic Fibers in the Penis of Human Fetuses at 28 Weeks Postconception

Bastos

Costa²,

Cardoso³

et al. 1999

Eur Urol

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“…Histological studies have shown an association between vasculogenic ED and ECM deposition [132][133][134][135][136][137][138][139]. The severity of ED has been correlated with a reduced smooth muscle/ECM ratio [1,[135][136][137].…”

Section: Effects Of Androgens On Corpus Cavernosum Extracellular Matrmentioning

confidence: 99%

Are Androgens Critical for Penile Erections in Humans? Examining the Clinical and Preclinical Evidence

Traish

Guay

2006

The Journal of Sexual Medicine

170

121

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Androgens are deemed critical for penile-tissue development, growth, and maintenance of erectile function, however, their role in erection, especially in humans, remains controversial. In this review, we summarize information from clinical and animal model studies to provide a comprehensive and rational argument for the role of androgens, or lack thereof, on penile erection ability in humans. The goal of this review is to present the clinical and preclinical evidence available in the literature with regard to testosterone and erectile physiology and engage the reader in this discussion. Ultimately, each reader will have to form his or her own conclusions based on the existing evidence. In humans, androgen-deficiency manifestations are noted in clinical situations such as: (i) inadequate development of the penis; and (ii) loss of erectile function in prostate cancer and benign prostatic hyperplasia patients managed with medical or surgical castration or antiandrogen therapy. Androgen treatment causes: (i) improvement in sexual function in hypogonadal patients treated with androgen supplementation; (ii) improvement in nocturnal penile tumescence in hypogonadal patients treated with androgens; (iii) improvement in erectile function with androgen supplementation in patients who did not respond to phosphodiesterase type 5 inhibitor therapy initially; and (iv) improvement in the well-being, mood, energy, and sexual function in aging men who have testosterone deficiency treated with androgen therapy. In contrast to animals, especially rodents in which the adrenal cortex does not synthesize androgens, the human adrenal is a source of peripherally circulating androgen precursors, thus, complete androgen insufficiency may not be observed in men at a younger age. Furthermore, in light of the concept that a threshold of androgen levels exists in animals and humans below which sexual function is diminished, further contributes to the complexity of understanding androgens role in erections, especially in humans. Nevertheless, based on the preclinical and clinical data available in the literature, to date, we infer that androgens play a critical role in maintaining erectile physiology in humans.

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Epidemiology of male sexual dysfunction

Tal

2016

Male Sexual Dysfunction

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Biochemical Alterations of the Tunica Albuginea in Impotence

Abstract: An alteration in the distribution and structure of the various collagen types and lectins in the tunica albuginea of impotent patients has been shown that may interfere with normal function and lead to impotence.

Cited by 8 publications

References 19 publications

Collagen and Elastic Fibers in the Penis of Human Fetuses at 28 Weeks Postconception

Collagen and Elastic Fibers in the Penis of Human Fetuses at 28 Weeks Postconception

Are Androgens Critical for Penile Erections in Humans? Examining the Clinical and Preclinical Evidence

Epidemiology of male sexual dysfunction

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