Biochemical and behavioral antagonism between fenfluramine and apomorphine in rats

Jori, A.; Cecchetti, Giancarlo; Ghezzi, D.; Samanin, R.

doi:10.1016/0014-2999(74)90225-8

Cited by 30 publications

(1 citation statement)

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“…The acute administration of fenfluramine stimulates the serotoninergic receptors by releasing 5-HT and inhibiting its reuptake (Fuxe et 01.. 1975;Garattini et d.. 1975). However, it has also been reported that high doses of fenfluramine may block dopaminergic receptors, since they increase homovanillic acid (HVA) in the striatum (Jori & Bernardi, 1972) and the dihydroxyphenylacetic acid (DOPAC) level in the brain (Fuller et a/., 1976) and antagonize the stereotyped behaviour induced by dopamine (Jori et d., 1974). In order to differentiate between dopaminergic and serotoninergic effects of fenfluramine, we measured aldosterone levels following drug administration.…”

Section: Discussionmentioning

confidence: 99%

Effect of Fenfluramine on Prolactin Secretion in Obese Patients: Evidence for Serotoninergic Regulation of Prolactin in Man

Barbieri

Magnoni

Rauhe

et al. 1983

Clinical Endocrinology

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The present investigation was carried out to study the effect of serotoninergic stimulation on prolactin (PRL) secretion in man. Fenfluramine (60 mg, orally), an anorexiant drug which under acute circumstances stimulates the serotoninergic system, was administered to eight obese patients. Compared with placebo, drug administration increased PRL significantly (P less than 0.05 at 180 and 300 min, P less than 0.01 at 240 min). No significant changes were observed after fenfluramine in blood pressure, plasma aldosterone (PA), plasma cortisol, plasma renin activity, serum electrolytes or growth hormone. Since it has been reported that dopaminergic blockade raises PA concentration, the lack of change in PA in obese patients treated with fenfluramine suggests that the observed increase in PRL induced by fenfluramine is likely to be mediated by serotoninergic stimulation.

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Section: Discussionmentioning

confidence: 99%