Biochemical and body composition analysis of nocturia in the elderly

Sugaya, Kimio; Nishijima, Saori; Oda, Masami; Owan, Tomoko; Miyazato, Minoru; Ogawa, Yoshihide

doi:10.1002/nau.20492

Cited by 54 publications

(65 citation statements)

References 44 publications

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“…Elderly patients with nocturia have been reported to have high levels of HANP and/or BNP (19,22). However, in the present study, the baseline level of HANP before exercise was within the normal range although its level was slightly decreased after exercise.…”

Section: Discussioncontrasting

confidence: 82%

“…According to our previous study, an increase of serum catecholamine levels was one of the characteristics of elderly persons with nocturia (19). Recently, it has been suggested that the occurrence of nocturia can be attributed to nocturnal polyuria and/ or diminished nocturnal bladder capacity (11,23), diastolic blood pressures, body weight, body fat ratio, edema ratio, serum catecholamines, TG, and T-Chol in this study.…”

Section: Discussionsupporting

confidence: 62%

“…That is, the improvement of nocturia by exercise is thought to be due to the induction of deeper sleep by walking in the evening or at night, which is the same mechanism as that of hypnotic therapy for nocturia. Our previous study showed that the serum melatonin level was extremely lower in elderly persons with nocturia over 2 times per night compared to the levels in elderly or younger persons without nocturia (19). Melatonin is produced by the pineal gland and is one of the strongest natural antioxidants as well as having a close relation to the timing of sleep in humans.…”

Section: Discussionmentioning

confidence: 99%

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Effects of walking exercise on nocturia in the elderly

et al. 2007

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We investigated whether nocturia in the elderly was improved by walking exercise, which involved walking rapidly for 30 min or more in the evening or night for 8 weeks. A questionnaire related to micturition and exercise, blood pressure, body composition analysis, blood biochemistry tests, and urinalysis were performed before and after 8 weeks of exercise to investigate the effects of walking. Thirty men (71 years old on average) continued the walking exercise for long enough to undergo evaluation. The number of episodes of nocturia decreased significantly (p < 0.001) from 3.3 ± 0.7 to 1.9 ± 0.8 after 8 weeks of walking exercise. The daytime urinary frequency, blood pressure, body weight, body fat ratio, edema ratio, serum catecholamines, triglycerides, and total cholesterol were also decreased. After 8 weeks of exercise, 20 of the subjects (67%) stated that sleep was deeper than before exercise. Assessment of the overall improvement showed that excellent or good results were obtained in 18 patients (60%). The main factor related to the influence of walking exercise on nocturia was that sleep became deeper, which increased the arousal threshold bladder volume. Walking exercise may also have a preventive effect on lifestyle-related diseases.

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Section: Discussioncontrasting

confidence: 82%

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Effects of walking exercise on nocturia in the elderly

et al. 2007

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“…It has been reported that HTN can increase the risk of nocturia by two folds, and the presence of these two conditions can simultaneously effect quality of life (45). Similar findings have been reported from elsewhere (46,47). In addition, a dose-response relationship for all age groups was found between HTN and nocturia with stronger association during old age (48).…”

Section: Discussionsupporting

confidence: 68%

Prevalence of Hypertension and Its Relationship with Health Complaints in Elderly Iranians: A Multi-Site Community-Based Study

Tanjani

Dobson

Babanejad

et al. 2017

Iran Red Crescent Med J

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“…typical cause of nocturia, and the plasma melatonin level of patients with nocturia is significantly lower than that of those without nocturia [14]. Hypnotics including zolpidem reduce the frequency of nocturia to about once nightly [8,12,15], and the effect of melatonin on nocturia has been reported to be similar to that of hypnotics [8].…”

Section: Resultsmentioning

confidence: 98%

Comparison of the Melatonin Receptor Agonist Ramelteon and the Non-Benzodiazepine Hypnotic Zolpidem for Nocturia

Mukouyama¹,

Sugaya²,

Nishijima³

et al. 2013

OJU

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To examine the efficacy of the melatonin receptor agonist ramelteon for nocturia, it was compared with zolpidem, a conventional non-benzodiazepine hypnotic. A total of 50 patients with nocturia (2 urinations/night) were enrolled. Subjects assigned odd numbers or even numbers were respectively prescribed 8 mg of ramelteon (n = 27; mean age: 75 years) or 5 mg of zolpidem (n = 23; mean age: 73 years) once a day before sleeping for 4 weeks. The daytime and nighttime frequencies of urination, as well as the results of global self-assessment by the patients, were compared between the two groups before and after 4 weeks of treatment. Both ramelteon and zolpidem caused a significant decrease of nocturia to about once per night after 4 weeks. The global self-assessment rating at 4 weeks was "good" or "fair" for more patients in the zolpidem group than in the ramelteon group, while the rating was "excellent" or "no change" for more patients in the ramelteon group. There were no serious adverse events in either group. Ramelteon was safe and effective for nocturia, achieving similar results to zolpidem. However, responders and non-responders to ramelteon were more clearly distinguished. Ramelteon might be effective for patients with sleep disturbance and nocturia because of low melatonin levels. Therefore, as diagnostic therapy for identification of nocturia caused by sleep disturbance and melatonin deficiency, ramelteon should be administered to patients who do not respond to alpha-1 antagonists and/or anticholinergic agents.

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Biochemical and body composition analysis of nocturia in the elderly

Abstract: These results suggest that sleep disturbance, hypertension, and excessive fluid intake are major factors contributing to an increased frequency of nocturnal urination (>twice per night) in the elderly.

Cited by 54 publications

References 44 publications

Effects of walking exercise on nocturia in the elderly

Effects of walking exercise on nocturia in the elderly

Prevalence of Hypertension and Its Relationship with Health Complaints in Elderly Iranians: A Multi-Site Community-Based Study

Comparison of the Melatonin Receptor Agonist Ramelteon and the Non-Benzodiazepine Hypnotic Zolpidem for Nocturia

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