Biochemical and Enzyme Responses in Rabbits Experimentally Fed Crude Oil Contaminated Diets

Ovuru, S. S.; Berepubo, N. A.; Nodu, Medubari B.; Dambo, L. B.

doi:10.1080/09712119.2003.9706453

Cited by 7 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the kidneys become impaired, the creatinine level in blood will rise. The presence of high concentration of urea and creatinine in the blood suggests the inability of the kidney to excrete these products (Ovuru et al 2004). The blood creatinine level of workers was 1.8 ± 0.21 mg/dl with a range of 1.5 to 2.4 mg/dl.…”

Section: Blood Creatinine Levelmentioning

confidence: 97%

Biochemical and Hematological Analysis after Exposure to Hazardous Materials during Shoe Making

Khan

Sultan

Rahman

2013

JBLS

View full text Add to dashboard Cite

show abstract

Section: Blood Creatinine Levelmentioning

confidence: 97%

Biochemical and Hematological Analysis after Exposure to Hazardous Materials during Shoe Making

Khan

Sultan

Rahman

2013

JBLS

View full text Add to dashboard Cite

show abstract

“…, and bicarbonate (HCO 3 -)) balance [98][99][100][101][102][103]. Impaired excretion of metabolic waste products, e.g., creatinine, urea, blood urea nitrogen (BUN), and uric acid [94,104,105], and altered acid-base homeostasis [102].…”

Section: Nephrotoxicitymentioning

confidence: 99%

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Ekpenyong

Asuquo

2017

Int J Occup Med Environ Health

View full text Add to dashboard Cite

The impact of health and environmental hazards, associated with the constituents of gasoline, on occupationally exposed workers has been recorded over the past few decades. However, the scientific literature on their pathogenic potential remains incomplete, which could affect the current understanding of the associated health risks. This review provides current information based on recently improved research techniques to evaluate gasoline toxicity profiles for humans. Our current knowledge provides insight into the intricate mechanism of gasoline-induced adverse effects, including the formation of reactive metabolites via bio-activation and subsequent generation of reactive oxygen species (ROS) and oxidative stress, which are involved in multiple mechanisms that are central to the aetiology of gasoline-induced toxicity. These mechanisms include covalent binding to deoxyribonucleic acid (DNA), leading to oxidative damage, tumor-suppression gene activity, and activation of pro-oncogenes. Furthermore, it results in induction of autoimmunity and local inflammatory responses, disruption of multiple neurotransmitters and immune cell function, derangement of various enzyme activities (e.g., sodiumpotassium adenosine triphosphate (Na + /K + /ATPase) activity, cytochrome P450 (CYP450), nitric oxide synthase (NOS), antioxidant enzyme activities, etc.), conjugation of bile, and non-specific cell membrane interaction, leading to damage of the membrane lipid bilayer and proteins. Available data suggests that exposure to gasoline or gasoline constituents have the potential to cause different types of illnesses. The data highlights the need to maintain safety measures via suitable research, medical surveillance, regulatory control, life style modification, early detection, and intervention to minimize exposure and manage suspected cases. They also present novel opportunities to design and develop effective therapeutic strategies against gasoline-induced detrimental effects. Int J Occup Med Environ Health 2017;30(1):1-26

show abstract

“…These pollutants have been implicated in causing many biochemical and toxicological effects on aquatic and terrestrial animals 1 . Although, various research work have been carried out on crude oil, very few has been directed to study the impact of crude oil on the endocrine system.…”

Section: Introductionmentioning

confidence: 99%

Preliminary investigation into the possible endocrine disrupting activity of Bonny light crude oil contaminated - diet on Wistar albino rats

Olawale¹,

Onwurah²

2010

Biokemistri

View full text Add to dashboard Cite

Many chemicals have recently been demonstrated to be Endocrine-disrupting compounds and may potential interfere with normal reproductive processes. In this study, we quantified the effect of Bonnylight crude oil contaminated diet on Wister albino rats. Forty-five rats (twenty male and twenty five females) were expose to Bonny -light crude oil contaminated diet at concentrations of 1%, 5% and 10% (w/w). Throughout the experiment, we observed 20 % reduction in fecundity in the 1% experimental group but in 5% experimental group, it was observed that there was a 45% reduction in fecundity when compared with parallel control group. However, the 10% group did not liter at all. There was a significant increase (p<0.05) in the testosterone level of male rats fed with 1% contaminated diet but the testosterone level of 5% and 10% treated group showed a significant reduction (p<0.05). The estrogen level in the female rats showed a general significant increase (p<0.05) in all the groups when compared with the female control group. This preliminary result suggest that Bonny-Light crude oil may have the potential to alter reproductive activity and hence a possible endocrine disruptor.

show abstract

Biochemical and Enzyme Responses in Rabbits Experimentally Fed Crude Oil Contaminated Diets

Abstract: Ovuru, S.S., Berepubo

Cited by 7 publications

References 11 publications

Biochemical and Hematological Analysis after Exposure to Hazardous Materials during Shoe Making

Biochemical and Hematological Analysis after Exposure to Hazardous Materials during Shoe Making

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Preliminary investigation into the possible endocrine disrupting activity of Bonny light crude oil contaminated - diet on Wistar albino rats

Contact Info

Product

Resources

About