Biochemical and histological evidence of thyroid gland dysfunction in estradiol valerate model of the polycystic ovary in Wistar rats

Alzahrani, Areej Ali; Alahmadi, Ahlam A.; Ali, Soad Shaker; Alahmadi, Bassam A.; Arab, Rana A; Wahman, Lobna F.; El-Shitany, Nagla A.

doi:10.1016/j.bbrc.2019.04.126

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…Therefore, low levels of thyroid hormones appeared to sensitize the ovaries to gonadotropin action and favor the development of PCOS in rats ( 46 ). In an animal PCOS model (female Wistar rats treated with estradiol valerate) several biochemical and histological evidence of thyroid gland dysfunction was observed, such as increased TSH serum levels, decreased T3 and T4 serum levels, small-sized thyroid follicles devoid of the colloid and increased connective tissue between follicles ( 47 ). Interestingly, treatment of the rats with PCOS with chamomile extract and metformin improved serum levels of TSH, T3, and T4 and counteracted most pathological changes in the thyroid gland ( 48 ).…”

Section: Resultsmentioning

confidence: 99%

Polycystic ovary syndrome and thyroid disorder: a comprehensive narrative review of the literature

Palomba,

Colombo,

Busnelli

et al. 2023

Front. Endocrinol.

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BackgroundPublished data on the relationship between polycystic ovary syndrome (PCOS) and thyroid dysfunction are sparse and confusing.ObjectiveTo comprehensively review data available in the literature regarding the relationship between PCOS and the thyroid function, and its abnormalities.MethodsNine main areas of interest were identified and analyzed according to the available evidence: 1) Evaluation of thyroid function for PCOS diagnosis; 2) Epidemiology data on thyroid function/disorders in patients with PCOS, and vice versa; 3) Experimental data supporting the relationship between thyroid function/disorders and PCOS; 4) Effects of thyroid function/disorders on PCOS features, and vice versa; 5) Effect of thyroid alterations on the cardiometabolic risk in women with PCOS; 6) Effect of thyroid abnormalities on reproductive outcomes in women with PCOS; 7) Relationship between thyroid function/abnormalities in patients with PCOS who are undergoing fertility treatment; 8) Effect of treatments for thyroid diseases on PCOS; and 9) Effect of treatments for PCOS on thyroid function. An extensive literature search for specific keywords was performed for articles published from 1970 to March 2023 using PubMed and Web of Science. Data were reported in a narrative fashion.ResultsPCOS is a diagnosis of exclusion for which diagnosis is possible only after excluding disorders that mimic the PCOS phenotype, including thyroid dysfunctions. However, the tests and the cutoff values used for this are not specified. Many experimental and clinical data suggest a relationship between perturbations of the thyroid function and PCOS. Direct and unequivocal evidence on the effects of thyroid function/disorders on PCOS features are lacking. High thyroid-stimulating hormone levels and subclinical hypothyroidism may be associated with significant worsening of several intermediate endpoints of cardiometabolic risk in women with PCOS. Thyroid abnormalities may worsen reproductive outcomes, especially in patients undergoing fertility treatment. To date, there are no data demonstrating the efficacy of thyroid medications on fertility and cardiometabolic risk in women with PCOS. Lifestyle modification changes, metformin, and vitamin D seem to improve thyroid function in the general population.ConclusionPCOS and thyroid disorders are closely related, and their coexistence may identify patients with a higher reproductive and metabolic risk. Regular screening for thyroid function and thyroid-specific autoantibodies in women with PCOS, particularly before and during pregnancy, is highly recommended.

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Section: Resultsmentioning

confidence: 99%

Polycystic ovary syndrome and thyroid disorder: a comprehensive narrative review of the literature

Palomba,

Colombo,

Busnelli

et al. 2023

Front. Endocrinol.

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“…Previous studies have suggested that HT could impact renal tissue, circulation, glomerular filtration rate, and tubular function in addition to water and salt reabsorption ( Kimmel et al, 2012 , Lippi et al, 2008 ). According to our recently published articles, the EV-PCOS model was associated with hypothyroid disease in rats ( Alahmadi et al, 2020 , Alzahrani et al, 2019 ). Therefore, HT may result in renal injury associated with PCOS.…”

Section: Discussionmentioning

confidence: 99%

“…PCOS was generated by injecting 2 doses of EV (0.2 mg × 2) 6 weeks apart. This design was formally documented by Farideh et al (2010) and clearly described in a previous study performed to produce PCOS associated with hypothyroidism ( Alahmadi et al, 2020 , Alzahrani et al, 2019 ). Rats treated with chamomile flower extract received 75 mg/kg/day, and rats treated with Met received 500 mg/kg/day.…”

Section: Methodsmentioning

confidence: 99%

“…Hypothyroidism (HT) is a medical condition identified by thyroid hormone depletion that leads to impaired metabolism ( Nagarajappa et al, 2014 ). Our research group recently reported an association of HT with PCOS in rats ( Alahmadi et al, 2020 , Alzahrani et al, 2019 ). HT involves multiple biochemical irregularities, including elevated serum creatinine and uric acid concentrations ( Khan and Majumder, 2013 , Mohamedali et al, 2014 ).…”

Section: Introductionmentioning

confidence: 96%

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Chamomile flower extract ameliorates biochemical and histological kidney dysfunction associated with polycystic ovary syndrome

Alahmadi

Wahman

et al. 2021

Saudi Journal of Biological Sciences

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“…Additionally, E 2 may regulate thyroid function by directly acting on thyroid cells [ 62 ]. The administration of double doses of estradiol valerate to the rats for six weeks induced thyroid hypoactivity, with elevated serum TSH level and decreased serum T3 and T4 levels [ 63 , 64 ]. High E 2 levels in women during fresh embryo transfer would increase the risk of thyroid dysfunction in their children [ 62 ].…”

Section: Genomic Effect Of Thsmentioning

confidence: 99%

A New Perspective on Thyroid Hormones: Crosstalk with Reproductive Hormones in Females

Ren

Zhu

2022

IJMS

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Accumulating evidence has shown that thyroid hormones (THs) are vital for female reproductive system homeostasis. THs regulate the reproductive functions through thyroid hormone receptors (THRs)-mediated genomic- and integrin-receptor-associated nongenomic mechanisms, depending on TH ligand status and DNA level, as well as transcription and extra-nuclear signaling transduction activities. These processes involve the binding of THs to intracellular THRs and steroid hormone receptors or membrane receptors and the recruitment of hormone-response elements. In addition, THs and other reproductive hormones can activate common signaling pathways due to their structural similarity and shared DNA consensus sequences among thyroid, peptide, and protein hormones and their receptors, thus constituting a complex and reciprocal interaction network. Moreover, THs not only indirectly affect the synthesis, secretion, and action of reproductive hormones, but are also regulated by these hormones at the same time. This crosstalk may be one of the pivotal factors regulating female reproductive behavior and hormone-related diseases, including tumors. Elucidating the interaction mechanism among the aforementioned hormones will contribute to apprehending the etiology of female reproductive diseases, shedding new light on the treatment of gynecological disorders.

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Biochemical and histological evidence of thyroid gland dysfunction in estradiol valerate model of the polycystic ovary in Wistar rats

Cited by 9 publications

References 21 publications

Polycystic ovary syndrome and thyroid disorder: a comprehensive narrative review of the literature

Polycystic ovary syndrome and thyroid disorder: a comprehensive narrative review of the literature

Chamomile flower extract ameliorates biochemical and histological kidney dysfunction associated with polycystic ovary syndrome

A New Perspective on Thyroid Hormones: Crosstalk with Reproductive Hormones in Females

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