Biochemical and Immunological Evaluation of Long Term Coformycin Administration in the Mouse

Lukey, Trevor; Snyder, Floyd F.

doi:10.1007/978-1-4757-0390-0_38

Cited by 1 publication

(2 citation statements)

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“…Beyond day 8, however, the level of parasitemia steadily declined, and by day 14, there was no significant difference between the DCF-treated and control mice. Possibly, the treated mice gradually became refractory to the effects of DCF, an effect which has been noted before in mice subjected to prolonged treatment (22). DCF treatment affected splenic growth; the number of cells in the spleens of treated mice was about 40% less than the number in mice not given DCF.…”

Section: Resultsmentioning

confidence: 75%

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The availability of purines influences both the number of parasites and the splenocyte levels of purine-metabolizing enzymes in trypanosome-infected mice

Albright

1988

Infect Immun

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Growth on Trypanosoma musculi in the murine host was limited by the availability of host purines. A portion of the spleen cells of infected mice (many of them granulocytes) displayed high levels of adenosine deaminase (ADA) and purine nucleoside phosphorylase, probably as a compensatory response to extracellular purine deficiency. Injections of adenosine or 2-deoxycoformycin stimulated significant increases in the growth of parasites. 2-Deoxycoformycin treatment also diminished parasite-induced splenomegaly. Treatment of mice with polyethylene glycol-modified ADA, a slowly catabolized form of ADA, had no effect on the course of T. musculi infection, indicating that the parasites can utilize purines other than adenosine. The apparent competition between parasites and host cells for available purines suggests that depletion of extracellular purines should be considered as an approach to treating extracellular trypanosome infections.

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Section: Resultsmentioning

confidence: 75%

“…DCF treatment was patterned after the procedure of other investigators (22,24). Treated mice were sacrificed at intervals, and the numbers of parasites in the blood and PS were determined.…”

Section: Resultsmentioning

confidence: 99%

The availability of purines influences both the number of parasites and the splenocyte levels of purine-metabolizing enzymes in trypanosome-infected mice

Albright

1988

Infect Immun

View full text Add to dashboard Cite

show abstract

Biochemical and Immunological Evaluation of Long Term Coformycin Administration in the Mouse

Cited by 1 publication

References 8 publications

The availability of purines influences both the number of parasites and the splenocyte levels of purine-metabolizing enzymes in trypanosome-infected mice

The availability of purines influences both the number of parasites and the splenocyte levels of purine-metabolizing enzymes in trypanosome-infected mice

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