Biochemical and Metabolical Pathways Associated with Microbiota-Derived Butyrate in Colorectal Cancer and Omega-3 Fatty Acids Implications: A Narrative Review

Gheorghe, Adelina Silvana; Negru, Șerban; Preda, Mădălina; Mihăilă, Raluca Ioana; Komporaly, Isabela Anda; Dumitrescu, Elena Adriana; Lungulescu, Cristian Virgil; Kajanto, Lidia; Georgescu, Bogdan; Radu, Emanuel Alin; Stănculeanu, Dana Lucia

doi:10.3390/nu14061152

Cited by 26 publications

(17 citation statements)

References 63 publications

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“…The Lachnospiraceae_NK4A136_group represents a gut bacterium naturally inhabiting healthy individuals (Stadlbauer et al, 2020). Interestingly, it is also a producer of butyrate, which is an important SCFA (Gheorghe et al, 2022) and has a positive role in maintaining the gut barrier integrity of mice (Hu et al, 2019). However, the function of Firmicutes_bacterium_M10-2 is still poorly understood in both humans and rodents.…”

Section: Discussionmentioning

confidence: 99%

Deficiency of migration inhibitory factor influences the gut microbiota of C57BL/6 mice infected with Plasmodium berghei ANKA

et al. 2022

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Cerebral malaria (CM), as one of the most common complications in severe malaria, has threatened millions of individuals’ neurological health and even their lives. Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory factor in humans, seems to be a risk factor for death in patients with CM, but its functional mechanism remains unclear. To verify whether affecting the intestinal microbes of the host was one of the mechanisms by which MIF regulates CM, C57BL/6 mice, including WT + PbA, MIF-KO + PbA and their uninfected controls, were sent for 16S rRNA-based sequencing targeting the V4 region of the intestinal microbiota through the Illumina MiSeq platform. The results showed that OTU clustering, alpha and beta diversity in the four groups involved had evident variation. The relative abundance at different taxonomic levels, especially the dominant intestinal flora, was obviously changed. The LEfSe analysis screened out several biomarkers, including significantly reduced Ligilactobacillus (Lactobacillus murinus) in WPbA mice compared to the WT group and Akkermansia (Akkermansia_muciniphila) in KPbA mice compared to the WPbA group. For MIF KO groups, mice infected with PbA or uninfected showed significant enrichment of producers of short-chain fatty acids, including Dubosiella and Faecalibaculum (Faecalibaculum rodentium) in KPbA, and Lachnospiraceae_NK4A136_group and Firmicutes_bacterium_M10-2 in KO. This study not only further proved the gut microbiota changes in C57BL/6 mice caused by PbA infection, but also found that MIF deletion directly affected the changes in the gut microbiota of C57BL/6 mice before and after PbA infection. This finding reveals a potential mechanism by which MIF regulates CM. Combining MIF with potential microbial biomarkers will provide a promising idea to develop combined drugs for improving CM in the future.

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Section: Discussionmentioning

confidence: 99%

Deficiency of migration inhibitory factor influences the gut microbiota of C57BL/6 mice infected with Plasmodium berghei ANKA

et al. 2022

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“…The amount of bacteria that produce butyrate may be increased by the administration of omega-3 fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] (Gheorghe et al, 2022). In the Zhuang et al study, it was noted that both EPA and DHA contribute to the increase of butyrate-producing bacteria while decreasing the bacteria that produce lipopolysaccharide, such as Bilophila and Escherichia/ Shigella (Zhuang et al, 2020).…”

Section: The Impact Of Diet On the Concentration Of Scfasmentioning

confidence: 99%

Section: The Impact Of Diet On the Concentration Of Scfasmentioning

confidence: 99%

Sodium butyrate in both prevention and supportive treatment of colorectal cancer

Kaźmierczak-Siedlecka

Marano²,

Merola³

et al. 2022

Front. Cell. Infect. Microbiol.

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Accumulating evidence suggests that selected microbiota-derived metabolites play a significant role in both tumor prevention and supportive treatment of cancer. Short-chain fatty acids (SCFAs), i.e., mainly acetate, proprionate, and butyrate, are one of them. Nowadays, it is known that butyrate is a key microbial metabolite. Therefore, in the current review, we focused on butyrate and sodium butyrate (NaB) in the context of colorectal cancer. Notably, butyrate is characterized by a wide range of beneficial properties/activities. Among others, it influences the function of the immune system, maintains intestinal barrier integrity, positively affects the efficiency of anti-cancer treatment, and may reduce the risk of mucositis induced by chemotherapy. Taking into consideration these facts, we analyzed NaB (which is a salt of butyric acid) and its impact on gut microbiota as well as anti-tumor activity by describing molecular mechanisms. Overall, NaB is available as, for instance, food with special medical purposes (depending on the country’s regulation), and its administration seems to be a promising option for colorectal cancer patients.

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“…These findings confirm that NaB is an effective treatment for CLM. Currently, Omega-3 polyunsaturated fatty acids (PUFAs) have been observed to significantly increase the density of bacteria known to produce butyrate, so they are thought to be useful to prevent dysbiosis of the gut microbiota and reduce the risk of developing CRC [ 157 ]. Corylin has been shown to reduce the risk of colitis-associated colon cancer (CAC) by modulating the composition of the gut microbiota, inflammation, and carcinogenesis, showing an effect of improving cancer.…”

Section: Radiotherapy For Cancer Based On the Gut Microbiotamentioning

confidence: 99%

New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer

Zuo

et al. 2022

Nutrients

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Cancer is the second most common cause of death among humans in the world, and the threat that it presents to human health is becoming more and more serious. The mechanisms of cancer development have not yet been fully elucidated, and new therapies are changing with each passing day. Evidence from the literature has validated the finding that the composition and modification of gut microbiota play an important role in the development of many different types of cancer. The results also demonstrate that there is a bidirectional interaction between the gut microbiota and radiotherapy treatments for cancer. In a nutshell, the modifications of the gut microbiota caused by radiotherapy have an effect on tumor radiosensitivity and, as a result, affect the efficacy of radiotherapy and show a certain radiation toxicity, which leads to numerous side effects. What is of new research significance is that the “gut-organ axis” formed by the gut microbiota may be one of the most interesting potential mechanisms, although the relevant research is still very limited. In this review, we combine new insights into the relationship between the gut microbiota, cancer, and radiotherapy. Based on our current comprehensive understanding of this relationship, we give an overview of the new cancer treatments based on the gut microbiota.

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Biochemical and Metabolical Pathways Associated with Microbiota-Derived Butyrate in Colorectal Cancer and Omega-3 Fatty Acids Implications: A Narrative Review

Cited by 26 publications

References 63 publications

Deficiency of migration inhibitory factor influences the gut microbiota of C57BL/6 mice infected with Plasmodium berghei ANKA

Deficiency of migration inhibitory factor influences the gut microbiota of C57BL/6 mice infected with Plasmodium berghei ANKA

Sodium butyrate in both prevention and supportive treatment of colorectal cancer

New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer

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