Biochemical and Microbiological Aspects of the Oral Cavity of Children and Young People with Neurological Impairment and Oropharyngeal Dysphagia

Duarte, Janaina Costa Marangon; Costa, Isabela Bazzo; Teixeira, Daniel De Bortoli; Fregatto, Luiz Fernando; Mendes, Claudemir Gregório; Mascarin, Aline Maria Noli; Silveira, Salum Bueno da; Serva, Bianca Eduarda Baptistella Mesquita; Comar, Livia Picchi; Silva, Roberta Gonçalves da; Buchaim, Daniela Vieira; Buchaim, Rogério Leone; Chagas, Eduardo Federighi Baisi; Agostinho, Francisco; Cola, Paula Cristina

doi:10.3390/life13061342

Cited by 3 publications

(1 citation statement)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, the project includes 280 patients, mostly diagnosed with CP and genetic syndrome. The diagnoses were made through genetic tests such as SNP array, exome analysis, and neuroimaging exams, with an average of 150 monthly visits 27 . The project has a multidisciplinary team that includes gastropediatricians, speech therapists, physiotherapists, occupational therapists, nurses, pharmacists, nutritionists, pediatric dentists, neuropediatricians, pulmonologists, orthopedists, and geneticists.…”

Section: Settingmentioning

confidence: 99%

Risk factor analysis of children and young people with cerebral palsy

Mascarin,

Costa,

Fregatto

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Currently, many individuals are affected by neurological disorders of various etiologies. In this study, we aimed to identify whether risk factors are associated with neurodevelopmental disorders in children and young people with cerebral palsy. We analyzed 258 medical records of people of both sexes with several neurological diagnoses. The analyzed data referred to demographic data, clinical data, and factors raised in neonatal anamnesis and neurodevelopmental disorders. The largest proportion of the sample is male, under 10 years of age, and is feeding orally. The risk factors were that the largest proportion underwent prenatal examination; had a cesarean section; and had low birth weight, hypoxia, and need for a neonatal intensive care unit. In relation to the neurodevelopmental disorder outcomes of interest, the largest proportion of the sample presented dysphagia, epilepsy, and gross motor function ≥ 4. We found that risk factors were not associated with neurodevelopmental disorders. However, the presence of hypoxia increases epilepsy risk.

show abstract

Section: Settingmentioning

confidence: 99%

Risk factor analysis of children and young people with cerebral palsy

Mascarin,

Costa,

Fregatto

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Examining the complex Interplay between gut microbiota abundance and short-chain fatty acid production in amyotrophic lateral sclerosis patients shortly after onset of disease

Fontdevila,

Povedano,

Domínguez

et al. 2024

Sci Rep

View full text Add to dashboard Cite

This study aimed to assess differences in the enteral microbiome of relatively recent-onset amyotrophic lateral sclerosis (ALS) patients (< 6–15 months since symptom onset) compared to healthy individuals, focusing on short-chain fatty acids (SCFAs) as potential mediators of host metabolism. We included 28 volunteers (16 ALS, 12 controls) with informed consent. No significant effect of ALS on alpha diversity (measuring the variety and abundance of species within a single sample, and indicating the health and complexity of the microbiome) was observed, but ALS patients had higher abundances of Fusobacteria and Acidobacteria . ALS subtypes influenced specific species, with increased Fusobacteria and Tenericutes in spinal ALS compared to bulbar ALS. ALS patients showed increased Enterobacter , Clostridium , Veillonella , Dialister , Turicibacter , and Acidaminococcus species and decreased Prevotella , Lactobacillus , and Butyricimonas . Correlations between species varied between ALS patients and healthy individuals and among ALS subtypes. No significant differences in SCFA concentrations were found, but spinal ALS samples showed a trend towards decreased propionate content. Relationships between SCFAs and phyla colonization differed by disease status. This study suggests distinct enteral microbiome characteristics in ALS patients, though the implications are unclear. Further research is needed to determine if these differences are causative or consequential and to explore their potential as diagnostic or therapeutic targets. The study also underscores the heterogeneity of microbiome constraints in ALS and the need for more research into ALS and SCFA metabolism. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-75083-z.

show abstract

Microbiome and Communication Disorders: A Tutorial for Clinicians

Venkatraman,

Davis,

Tseng

et al. 2024

J Speech Lang Hear Res

View full text Add to dashboard Cite

Purpose: Emerging research in the field of microbiology has indicated that host–microbiota interactions play a significant role in regulating health and disease. Whereas the gut microbiome has received the most attention, distinct microbiota in other organs (mouth, larynx, and trachea) may undergo microbial shifts that impact disease states. A comprehensive understanding of microbial mechanisms and their role in communication and swallowing deficits may have downstream diagnostic and therapeutic implications. Method: A literature review was completed to provide a broad overview of the microbiome, including differentiation of commensal versus pathogenic bacteria; cellular mechanisms by which bacteria interact with human cells; site-specific microbial compositional shifts in certain organs; and available reports of oral, laryngeal, and tracheal microbial dysbiosis in conditions that are associated with communication and swallowing deficits. Results/Conclusions: This review article is a valuable tutorial for clinicians, specifically introducing them to the concept of dysbiosis, with potential contributions to communication and swallowing deficits. Future research should delineate the role of specific pathogenic bacteria in disease pathogenesis to identify therapeutic targets.

show abstract

Biochemical and Microbiological Aspects of the Oral Cavity of Children and Young People with Neurological Impairment and Oropharyngeal Dysphagia

Cited by 3 publications

References 50 publications

Risk factor analysis of children and young people with cerebral palsy

Risk factor analysis of children and young people with cerebral palsy

Examining the complex Interplay between gut microbiota abundance and short-chain fatty acid production in amyotrophic lateral sclerosis patients shortly after onset of disease

Microbiome and Communication Disorders: A Tutorial for Clinicians

Contact Info

Product

Resources

About