Biochemical and Microbiological Studies of the Semen, Mouth swab and Serum of infertile Nigeria Male (LB232)

Abstract

There is an increase in male infertility in Nigeria mostly due to abnormal seminal fluid which may be found in up to 60% of infertile male, resulting in a multi‐ factorial health related issues. This research evaluates the relationship between oral health and infertility in Nigeria men. A total of 43 men were recruited, grouped into 30 infertile men and 13 controls; aged 30 to 50 years, bio data and health related information were collected. Microbial spectrum of seminal and mouth swab was analysed, the following biochemical parameters: lipid profile, testosterone, prolactin, LH and FSH were analysed using serum samples. The average semen volume, concentration and motility of infertile group was significantly lower than the normal group, with a corresponding increase in abnormal spermatozoa morphology of the test group compared to the control (p<0.05). The spectra of bacteria revealed Staphylococcus aureus as the most common bacteria isolate in both the semen culture and the mouth swab of infertile candidates. The level of Testosterone was significantly decreased in the infertile men (Test) group, while the levels of Prolactin, FSH and LH were significantly increased. HDL showed a significant decrease in the test group compared to the control; however there is no significant difference in Creatinine and Urea level of both groups. The results did not confirm any mouth infection that has a direct correlation to infertility status of men; however, there is an increase in seminal fluid infections with decreasing sperm concentration, volume, motility and morphology. Hence, there is no direct association between mouth infection and male infertility.