Biochemical and Molecular Investigation of the Effect of Saponins and Terpenoids Derived from Leaves of Ilex aquifolium on Lipid Metabolism of Obese Zucker Rats

Pachura, Natalia; Kupczyński, Robert; Lewandowska, Kamila; Włodarczyk, Maciej; Klemens, Marta; Kuropka, Piotr; Nowaczyk, Renata; Krzystek−Korpacka, Małgorzata; Bednarz−Misa, Iwona; Sozański, Tomasz; Pogoda-Sewerniak, K.; Szumny, Antoni

doi:10.3390/molecules27113376

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…Terpenes from Ilex aquifolium have been studied in order to understand their anti-obesity mechanism. Pachura, et al [82] evaluated the effect of the terpenoid fraction of extracts from I. aquifolium leaves on the expression of genes related to the lipid metabolism and on the hepatic architecture using obese Zucker male rats as in vivo model. Firstly, the composition of I. aquifolium leaves was analyzed, the monoterpenes p-cymene, α-phellandrene and α-pinene, as well as the triterpenes oleanolic and ursolic acid were found.…”

Section: Terpenes Modulating Overweight and Obesitymentioning

confidence: 99%

Current Evidence of Natural Products Against Overweight and Obesity: Molecular Targets and Mechanisms of Action

Elizalde-Romero,

Leyva-López,

Contreras-Angulo

et al. 2024

Preprint

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Overweight and Obesity are global health and economic concerns. According to the World Health Organization, the number of individuals with obesity has nearly tripled since 1975. This health issue is currently considered an epidemic, affecting over 1.9 billion adults and 340 million children and adolescents. It contributes to more than 5 million deaths each year and has a global economic burden that will reach $4.32 trillion annually by 2035, according to the World Obesity Federation. This disease can affect every system of the human body and can lead to complications such as metabolic syndrome, diabetes, cancer, dyslipidemia, cardiovascular diseases, and hypertension, among others. Treatment may sometimes include diet, exercise, drugs, and bariatric surgery. Nonetheless, not all people have access to these treatments, and public health strategies consider prevention the most important factor. In this regard, recent investigations are aiming to find alternatives and adjuvants for the treatment of obesity, its prevention, and the reversion of some of its complications, using natural sources of anti-obesogenic compounds like polyphenols, terpenes, alkaloids, saponins, among others. In this review, we gather the most current information using PubMed, Google Scholar, Scopus, Cochrane, and Web of Science. We present and discuss the current information about natural products that have shown anti-obesogenic effects at a molecular level. We also consider the impact of dietary habits and lifestyle in preventing overweight and obesity due to the evidence of the benefits of certain foods and compounds consumed regularly. We discuss mechanisms, pathways, and receptors involved in the modulation of obesity, especially those related to inflammation and oxidative stress linked to this disease, due to the relevance of these two aspects in developing complications.

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Section: Terpenes Modulating Overweight and Obesitymentioning

confidence: 99%

Current Evidence of Natural Products Against Overweight and Obesity: Molecular Targets and Mechanisms of Action

Elizalde-Romero,

Leyva-López,

Contreras-Angulo

et al. 2024

Preprint

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“…Saponine können unter anderem die Einlagerung von Fetten in Geweben (Adipogenese) und die Effektivität der Lipase hemmen. Dieses in der Bauchspeicheldrüse gebildete Enzym fördert die Verdauung und Aufnahme von Fetten im Dünndarm [ 4 ].…”

Section: Eine Eigenbrötlerin Innerhalb Der Familieunclassified

Die deutsche Mate

Vigl

2023

Deutsche Heilpraktiker-Zeitschrift

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Antiviral and Cytotoxic Activities of Ilex aquifolium Silver Queen in the Context of Chemical Profiling of Two Ilex Species

Pachura,

Włodarczyk,

Bażanów

et al. 2024

Molecules

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The leaves of Ilex paraguariensis (known as Yerba mate), used as a popular beverage, are a very well-recognized plant material with various biological activities, including analeptic (because of caffeine), anti-obesity (phenolics, saponins), antimicrobial, and antiviral (phenolics, saponins). Here, the chemical compositions of the leaves of two European Ilex species (× meserveae and aquifolium) with three varieties each were investigated. The terpenoid, saponin, and polyphenolic fractions were submitted for LC-MS or GC-MS analysis against a standard Mate leaf. In addition, the aroma profiles of all the species were analysed using HS-SPME-Arrow prior to GC-MS analysis. All fractions were subjected to antiviral and cytotoxic assays. We found 86 compounds in all accessions, with limonene, linalool, and p-cymene being predominant. There were minor similarities between the volatile compositions of the European and South American species. We found ursolic and oleanolic acid to be the main compounds in the terpenoid fraction. Mono-caffeoylquinic acids and di-caffeoylquinic acids were the main constituents of the polar fractions. About 180 compounds from the saponin group were tentatively identified, of which 9 and 3 were selected as distinctive markers for I. meserveae and I. aquifolium, respectively. Based on chemical screening, I. aquifolium Silver Queen was chosen as the source of terpenoid and saponin fractions and polyphenol extracts. The most substantial inhibition of cancer cell growth was observed with saponin in the case of the MCF7 (human breast cancer) cell line, while for LoVo and L929 cell lines (human colorectal cancer and reference mouse fibroblasts), it was slightly weaker. These results should be analysed further as a promising chemoprevention of colorectal and gastrointestinal cancers. Saponin and polyphenolic extracts exhibited similar activities against HSV-1 and HAdV-5, with 4-log reduction in virus titres. This study focuses our attention on a field of potential antiviral formulations derived from European holly.

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Biochemical and Molecular Investigation of the Effect of Saponins and Terpenoids Derived from Leaves of Ilex aquifolium on Lipid Metabolism of Obese Zucker Rats

Cited by 5 publications

References 46 publications

Current Evidence of Natural Products Against Overweight and Obesity: Molecular Targets and Mechanisms of Action

Current Evidence of Natural Products Against Overweight and Obesity: Molecular Targets and Mechanisms of Action

Die deutsche Mate

Antiviral and Cytotoxic Activities of Ilex aquifolium Silver Queen in the Context of Chemical Profiling of Two Ilex Species

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