Biochemical and molecular mechanisms underlying the chemopreventive efficacy of rosmarinic acid in a rat colon cancer

Venkatachalam, Karthikkumar; Gunasekaran, S.; Nalini, Namasivayam

doi:10.1016/j.ejphar.2016.07.051

Cited by 40 publications

(23 citation statements)

References 39 publications

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“…14 RA, CA and vitexin were of interested compounds in leaf decoction of TL with broad biological effects. 13 RA and CA showed antidote activity [26][27][28] and acted as a chemopreventive agent against cancer 29,30 and diabetes mellitus. 31 These effects are attributed to its excellent anti-inflammatory and anti-oxidant activity.…”

Section: Resultsmentioning

confidence: 99%

Development and Validation of Stability Indicating HPLC Method for Determination of Caffeic Acid, Vitexin and Rosmarinic Acid in Thunbergia laurifolia Leaf Extract

Woottisin¹,

Kongkiatpaiboon²,

Sukprasert³

et al. 2020

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Thunbergia laurifolia has been a popular herb used in Thai traditional medicine for detoxification and as antipyretic. It contains rosmarinic acid (RA), caffeic acid (CA) and vitexin as major compounds. In order to control the herbal quality, the stability indicating high-performance liquid chromatography (HPLC) was developed and validated. The stability study of compounds in T. laurifolia leaf extract was investigated. The chromatographic separation was performed using a reversed-phase C18 column and mobile phase consisted of 0.5% acetic acid and methanol using a gradient elution with 1.0 mL/min flow rate. The detection wavelength was set at 330 nm. The method was validated for its linearity, precision, accuracy, limit of detection and limit of quantitation. Forced degradation of three compounds in extract showed that they were stable in oxidative condition, but highly labile under alkaline hydrolytic conditions. All three compounds in T. laurifolia leaf extract were stable at room temperature at least 3 months while a remarkable decrease of RA, vitexin and CA in the extract were found in accelerated condition. This finding could be applied for predicting the storage recommendation and expiry of T. laurifolia extract and its related pharmaceutical products.

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Section: Resultsmentioning

confidence: 99%

Development and Validation of Stability Indicating HPLC Method for Determination of Caffeic Acid, Vitexin and Rosmarinic Acid in Thunbergia laurifolia Leaf Extract

Woottisin¹,

Kongkiatpaiboon²,

Sukprasert³

et al. 2020

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“…Nunes et al (2017) [130] noted that RA displays several health beneficial effects (including antimicrobial and anti-carcionogenic properties) the magnitude of which depends greatly on both its intake and bioavailability. [136] investigated the mode and molecular mechanisms that govern the chemoprotective action of RA against colon cancer in rats. The authors reported that supplementation with RA (5-20 mg/kg body wt) protected treated rats from the deleterious effects caused by the colon carcinogenic 1,2-dimethylhydrazine.…”

Section: Rosmarinic Acid (Ra)mentioning

confidence: 99%

“…RA protected treated rats from the deleterious effects caused by colon carcinogen, 1,2-dimethylhydrazine. [136] Vanillic acid (VA)…”

Section: Phenolic Acid Experimental Conditions Conclusion Of Study/hmentioning

confidence: 99%

Phenolic Acids of Plant Origin—A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties

Kiokias

Proestos

Oreopoulou

2020

Foods

178

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Nature has generously offered a wide range of herbs (e.g., thyme, oregano, rosemary, sage, mint, basil) rich in many polyphenols and other phenolic compounds with strong antioxidant and biochemical properties. This paper focuses on several natural occurring phenolic acids (caffeic, carnosic, ferulic, gallic, p-coumaric, rosmarinic, vanillic) and first gives an overview of their most common natural plant sources. A summary of the recently reported antioxidant activities of the phenolic acids in o/w emulsions is also provided as an in vitro lipid-based model system. Exploring the interfacial activity of phenolic acids could help to further elucidate their potential health properties against oxidative stress conditions of biological membranes (such as lipoproteins). Finally, this review reports on the latest literature evidence concerning specific biochemical properties of the examined phenolic acids.

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“…Natural products with bioactive components have gained increasing attention in cancer prevention and therapy, due to their compatibility with biological target sites and less induced toxicity to normal cells (Remely et al 2015). Several preclinical studies have reported that many phytochemicals with anti-inflammatory, anti-oxidation and anti-proliferative properties can prevent cancer initiation and development by inducing apoptosis and activating antioxidant enzymes (Venkatachalam et al 2016;Leone et al 2017). However, the translation of chemopreventive properties of phytochemicals to clinical practice has not been yet achieved.…”

Section: Phytochemicals In Cancer Preventionmentioning

confidence: 99%

Phytochemicals in cancer prevention: modulating epigenetic alterations of DNA methylation

Pop

Enciu

Tarcomnicu³

et al. 2019

Phytochem Rev

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Cancer can take many years to develop from initiation to progression. The long period of development might represent an opportunity to use multi-functional, multi-targeted preventive drugs to block or reverse tumorigenesis. One path to cancer prevention could be to target and reverse the early epigenetic alterations. Unlike genetic mutations, they are potentially reversible and can be restored to their normal state. Epidemiological studies have revealed the close link between rich diets in bioactive compounds and the low incidence of different types of cancer. Thus, the study regarding the impact of bioactive nutrients on the epigenome has become widespread, with focus on the modulation of epigenetic mechanisms of gene expression, such as genomic DNA methylation. Following altered activity and expression of DNA methyl transferases and ten-eleven translocation enzymes, different types of cancers exert local DNA hypermethylation of gene promoters of tumor suppressor genes or of non-coding RNAs (microRNAs and long-noncoding RNAs), as well as global hypomethylation. Recently, the potential of phytochemicals to modulate epigenetic events in human health has become evident, although specific molecular mechanisms are still unclear. Phytochemicals and other bioactive dietary compounds can restore global and gene-specific promoter DNA methylation patterns by reactivating DNA methyltransferases or by providing the provision of methyl groups. Several natural products, such as EGCG, curcumin, sulforaphane, have shown DNMT inhibitory activity, but this property needs more in-depth investigations. This review focuses on the impact of modified DNA methylation pattern on early carcinogenesis and summarizes the effects/mechanism of phytochemical interventions on this type of epigenetic alterations.

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Biochemical and molecular mechanisms underlying the chemopreventive efficacy of rosmarinic acid in a rat colon cancer

Cited by 40 publications

References 39 publications

Development and Validation of Stability Indicating HPLC Method for Determination of Caffeic Acid, Vitexin and Rosmarinic Acid in Thunbergia laurifolia Leaf Extract

Development and Validation of Stability Indicating HPLC Method for Determination of Caffeic Acid, Vitexin and Rosmarinic Acid in Thunbergia laurifolia Leaf Extract

Phenolic Acids of Plant Origin—A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties

Phytochemicals in cancer prevention: modulating epigenetic alterations of DNA methylation

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