Biochemical and morphological pathology of the foot of the schistosome vector <i>Biomphalaria glabrata</i> infected with <i>Schistosoma mansoni</i>

Thompson, S. N.; Lee, R. W. K.; Mejia-Scales, V.; El-Din, M. Shams

doi:10.1017/s0031182000079257

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…In another study by Thompson et al in vivo 31 P NMR was used to explore the difference between S. mansoni infected and non-infected Biomphalaria galbrata snails. The foot of the infected snails had a lower phosphoarginine to adenosine triphosphate than non-infected snails (Thompson et al 1993).…”

Section: Profiling Of the Host Metabolic Statusmentioning

confidence: 99%

The evolution of metabolic profiling in parasitology

Holmes

2010

Parasitology

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The uses of metabolic profiling technologies such as mass spectrometry and nuclear magnetic resonance spectroscopy in parasitology have been multi-faceted. Traditional uses of spectroscopic platforms focused on determining the chemical composition of drugs or natural products used for treatment of parasitic infection. A natural progression of the use of these tools led to the generation of chemical profiles of the parasite in in vitro systems, monitoring the response of the parasite to chemotherapeutics, profiling metabolic consequences in the host organism and to deriving host-parasite interactions. With the dawn of the post-genomic era the paradigm in many research areas shifted towards Systems Biology and the integration of biomolecular interactions at the level of the gene, protein and metabolite. Although these technologies have yet to deliver their full potential, metabolic profiling has a key role to play in defining diagnostic or even prognostic metabolic signatures of parasitic infection and in deciphering the molecular mechanisms underpinning the development of parasite-induced pathologies. The strengths and weaknesses of the various spectroscopic technologies and analytical strategies are summarized here with respect to achieving these goals.

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Section: Profiling Of the Host Metabolic Statusmentioning

confidence: 99%

The evolution of metabolic profiling in parasitology

Holmes

2010

Parasitology

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“…Infection with S. mansoni causes relatively modest changes in defense-related parameters in susceptible host individuals, although miracidial penetration and migration does result in considerable pathology (Thompson et al 1993), leading to alterations in host metabolism as seen by changes in the plasma protein composition, and levels of glucose and urea (e.g., Becker 1983;Rupprecht et al 1989). Host and parasite seem to reach a metabolic equilibrium about 6 weeks after infections when the majority of sporocyst proliferation in the digestive gland has been completed, although disruption of the gonad resulting in parasitic castration is common (Crews and Yoshino 1989).…”

Section: How Do Molluscs Respond To Parasite Infections?mentioning

confidence: 99%

Host—Parasite Interactions in Molluscs

Fryer

Bayne

1996

Progress in Molecular and Subcellular Biology

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“…This exhibition of partner choice implies a recognition mechanism. Thompson et al (1993) described foot lesions caused by cercariae, which could be detected by potential partners.…”

Section: Partner Choicementioning

confidence: 99%

Parasite-altered behaviour: impact of infection and starvation on mating inBiomphalaria glabrata

Rupp

1996

Parasitology

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SUMMARYVery little is known about parasite-altered mating behaviour. This paper describes two experiments on the impact of infection and starvation on mating inBiomphalaria glabratasnails. In the first experiment, snails were infected with the parasitic trematodeSchistosoma mansoni. During both the early and the late stages of infection, snails were allowed to mate with individuals of the same infection status and uninfected controls. Their mating activities were filmed and later analysed. The mating frequencies of patently infected (shedding) snails were found to be lower than those of controls. This is thought to result from stress induced by the pathology. Successfully infected snails were found to mate more often as males than as females. This is seen as a compensation for the reduced fecundity caused by trematode infection. Successfully infected snails also exhibited partner choice. More matings were found between snails of the opposite infection status than among snails of the same infection status. This may be explained by the good genes hypothesis and can be seen as a specific response to schistosome infection. In the second experiment, starved snails were allowed to mate with starved and control snails. They mated less often than controls and more often as males than as females, controls showing the opposite pattern. This may be considered to be a general stress response. No partner choice has been found with starved snails. It is suggested that partner choice in infected snails occurs in response to specific rather than general stress.

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Biochemical and morphological pathology of the foot of the schistosome vector Biomphalaria glabrata infected with Schistosoma mansoni

Cited by 7 publications

References 24 publications

The evolution of metabolic profiling in parasitology

The evolution of metabolic profiling in parasitology

Host—Parasite Interactions in Molluscs

Parasite-altered behaviour: impact of infection and starvation on mating inBiomphalaria glabrata

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