Biochemical and pharmacological consequences of the interaction between methotrexate and ketoprofen in the rabbit

Perrin, A; Milano, G.; Thyss, A.; Cambon, P; Schneider, M.

doi:10.1038/bjc.1990.369

Cited by 12 publications

(3 citation statements)

References 24 publications

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“…To investigate the mechanism underlying a severe interaction between methotrexate and ketoprofen observed clinically ), Perrin et al (1990) studied the simultaneous administration of the 2 drugs in the rabbit. The administration of keto prof en increased the volume of distribution (V d) of methotrexate, due to a decrease in the amount of methotrexate that was protein bound.…”

Section: Methotrexatementioning

confidence: 99%

Pharmacokinetic Drug Interactions with Anticancer Drugs

Loadman

Bibby

1994

Clinical Pharmacokinetics

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Drug dosage is of paramount importance in the treatment of cancer, the aim being to optimise drug exposure with a view to maximising antitumour effect and minimising normal tissue toxicity. Pharmacokinetic parameters of anticancer drugs vary considerably from patient to patient. Most clinically useful drug regimens consist of a cocktail of drugs with different mechanisms of action and hence different toxicity profiles. Therefore, it is even more difficult to optimise drug dosage for individual patients. Variability in the pharmacokinetic profile of anticancer agents in individual patients can be further complicated by pharmacokinetically based drug interactions between different anticancer drugs or anticancer drugs and other concomitant medication. Most of the reported studies provide useful information and identify major interactions, but many also demonstrate the difficulty in identifying therapeutically important drug interactions in patients. Even with all the problems associated with acquiring suitable data from cancer patients it is clear that drug interactions do occur and that these can be clinically significant. It is important that potential interactions are identified early in the drug development of new anticancer drugs. This may be made possible by the rapid improvements in analytical techniques and the availability of more appropriate clinically relevant model systems. Therefore, the therapeutic significance of any detected interactions may be assessed, and steps to avoid them may be established, before the drug is under clinical investigation.

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Section: Methotrexatementioning

confidence: 99%

Pharmacokinetic Drug Interactions with Anticancer Drugs

Loadman

Bibby

1994

Clinical Pharmacokinetics

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“…High‐performance liquid chromatography (HPLC) is usually used to analyze low molecular weight drugs . The analysis of macromolecules, such as bDMARDs by HPLC is difficult.…”

Section: Introductionmentioning

confidence: 99%

“…[29,30] High-performance liquid chromatography (HPLC) is usually used to analyze low molecular weight drugs. [31][32][33] The analysis of macromolecules, such as bDMARDs by HPLC is difficult. Therefore, appropriate pretreatment and suitable conditions of chromatography are necessary to measure bDMARDs in blood.…”

Section: Introductionmentioning

confidence: 99%

Simple and rapid analysis of tocilizumab using HPLC‐fluorescence detection method

et al. 2019

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We developed a novel assay using high‐performance liquid chromatography (HPLC) with fluorescence detection for the determination of tocilizumab (TCZ), after it has undergone a facile and rapid pretreatment. TCZ belongs to the same subclass as IgG1 (Immunoglobulin G subclass 1), and we could separate TCZ from IgG1 without antigen–antibody reactions, with the novel detection method. The separation of these antibodies was achieved by pretreatment with an organic solvent containing a base, such as trimethylamine and triethylamine. The effect of these bases on the separation of TCZ is related to the hydrophobicity of the base rather than the electrostatic charge. The results indicated that the surface charge of antibodies changed because of the structural change, even though the difference in the amino acid sequences of the antibodies was very low. Our method is available for the separation of the antibody subclasses, and it would be useful to assay TCZ in blood.

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Drug Interactions at Plasma and Tissue Binding Sites

McElnay¹

1996

Mechanisms of Drug Interactions

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Biochemical and pharmacological consequences of the interaction between methotrexate and ketoprofen in the rabbit

Cited by 12 publications

References 24 publications

Pharmacokinetic Drug Interactions with Anticancer Drugs

Pharmacokinetic Drug Interactions with Anticancer Drugs

Simple and rapid analysis of tocilizumab using HPLC‐fluorescence detection method

Drug Interactions at Plasma and Tissue Binding Sites

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