2019
DOI: 10.1016/j.cbi.2019.03.023
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Biochemical and physiological properties of K+ channel-associated AKR6A (Kvβ) proteins

Abstract: Voltage-gated potassium (Kv) channels play an essential role in the regulation of membrane excitability and thereby control physiological processes such as cardiac excitability, neural communication, muscle contraction, and hormone secretion. Members of the Kv1 and Kv4 families are known to associate with auxiliary intracellular Kvβ subunits, which belong to the aldo-keto reductase superfamily. Electrophysiological studies have shown that these proteins regulate the gating properties of Kv channels. Although t… Show more

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Cited by 6 publications
(3 citation statements)
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References 93 publications
(114 reference statements)
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“…Coronary arterial myocyte Kv1 channels are essential for proper metabolic hyperemia 7 , 9 , 10 , 25 , 26 . Under native conditions, these channels associate with ancillary Kvβ proteins, which bind pyridine nucleotides with high affinity 15 , 27 . Based on results presented in Figs.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Coronary arterial myocyte Kv1 channels are essential for proper metabolic hyperemia 7 , 9 , 10 , 25 , 26 . Under native conditions, these channels associate with ancillary Kvβ proteins, which bind pyridine nucleotides with high affinity 15 , 27 . Based on results presented in Figs.…”
Section: Resultsmentioning
confidence: 99%
“…The Kvβ proteins are functionally active aldo-keto reductases (AKRs) that bind pyridine nucleotides (i.e., NAD(P)(H)) with high affinity. These proteins regulate Kv1 function in heterologous systems as well as native excitable cells 15 18 . Accordingly, we tested the hypothesis that changes in myocardial oxygen consumption and demand modulate the redox ratio of pyridine nucleotides in arterial smooth muscle and thereby influence the regulatory mode of Kvβ proteins and Kv activity.…”
Section: Introductionmentioning
confidence: 99%
“…Nonetheless, the use of mice allows for testing the effects of time- and intensity-controlled exercise in the absence of confounding environmental complexities such as dietary variations, psychosocial stressors, and xenobiotic exposures. Moreover, we acknowledge that Kvβ2 may have physiological roles beyond that of vascular regulation (e.g., autonomic balance, immunity) that may also impact exercise-induced tissue adaptations ( 46 ). Indeed, our conclusions are partially based on data acquired from mice with global deletion of Kvβ2, which is highly expressed in excitable cells outside of the cardiovascular system.…”
Section: Discussionmentioning
confidence: 99%