Biochemical Assessment of Antidepressive Drugs

Ghose, Karabi

doi:10.1007/978-1-349-06038-2_6

Cited by 1 publication

(1 citation statement)

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“…Despite the evidence that antidepressant drugs that inhibit the transport of serotonin may act in a non-competitive fashion at low concentrations (Lingjaerde, 1979), many investigators have shown that this mechanism may be studied in platelet rich human plasma using 3H or 14Clabelled amines thereby allowing reliable information on the action of antidepressants in depressed patients to be obtained. A detailed account of the methods used in such studies has been published by Ghose (1982).…”

Section: Markers Of Central Serotonin Functionmentioning

confidence: 99%

Neurotransmitter receptors, endocrine responses and the biological substrates of depression: A review

Leonard

1986

Human Psychopharmacology

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This review attempts to assess critically the evidence which implicates a disorder of CNS neurotransmission in the aetiology of depression. Evidence for such a disorder has been obtained from changes in neuroendocrine function and in the activity of neurotransmitter receptors located on platelets and lymphocytes of depressed patients. Such studies are important not only because they give an insight into the possible biochemical basis of the illness, but also because they may be used as markers for the onset of depression and of response to treatment. The review concludes with a brief assessment of the change in immune responsiveness which may be associated with the onset of depression. Such studies support the view that the biological changes occurring in depression are not restricted to the brain and therefore open up the possibility that biochemical tests based on analysis of a blood sample may form a useful adjunct to clinical assessment.

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Section: Markers Of Central Serotonin Functionmentioning

confidence: 99%

Neurotransmitter receptors, endocrine responses and the biological substrates of depression: A review

Leonard

1986

Human Psychopharmacology

View full text Add to dashboard Cite

show abstract

Biochemical Assessment of Antidepressive Drugs

Cited by 1 publication

References 59 publications

Neurotransmitter receptors, endocrine responses and the biological substrates of depression: A review

Neurotransmitter receptors, endocrine responses and the biological substrates of depression: A review

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