Biochemical Changes Accompanying the Ingestion of a Carboxylic Cation Exchanger in the Hydrogen, Ammonium, Sodium, Potassium, or Calcium Form

Greenman, L.; Peters, J. H.; Mateer, F. M.; Weigand, F. A.; Wilkins, Donald H.; Tarail, R.; Rhodes, Gerald R.; Danowski, T. S.

doi:10.1172/jci102521

Cited by 37 publications

(12 citation statements)

References 11 publications

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“…Statistical comparison of the changes recorded during hydrogen-potassium resin ingestion, by means of the "t" test with a larger group of control periods described in a preceding paper, indicates that they are indistinguishable in magnitude and direction. It is clear, therefore, that in these subjects there is no evidence of the hyperchloremia and metabolic acidosis which characteristically occurred during hydrogen cycle resin therapy of equal duration (1). It should be em- End of H resin The columns represent mean changes in serum HCO,, Cl, Na, and K in milliequivalents per liter and in serum Ca and inorganic P in milligrams % between the onset and end of control periods and of periods in which equal parts of H and K cycle resins were ingested in amounts indicated in Table I.…”

Section: Resultsmentioning

confidence: 82%

“…In all three groups of studies control periods were included when possible. The experimental procedures and other pertinent information have been described earlier (1,2). The dietary regimens employed, the results of blood and serum analyses, and the available balance data are presented in tabular form.…”

Section: Methodsmentioning

confidence: 99%

“…Pittsburgh, Pa.) (Submitted for publication April 23, 1951; accepted July 9, 1951) Evidence has been presented indicating that a sufficient intake of a carboxylic cation exchanger in the potassium cycle increases the stool output of sodium in absolute as well as in relative terms (1)(2)(3)(4). Two other findings accompanying the use of this form of the resin are noteworthy: a) a significant proportion of the potassium taken with or as part of the resin can be retained in the body and b) ingestion of this particular resin does not produce acidosis.…”

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confidence: 99%

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Acidifying and Non-Acidifying Carboxylic Resin Mixtures Used Alone and With Acth or Cortisone

Peters¹,

Danowski²,

Greenman³

et al. 1951

J. Clin. Invest.

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Evidence has been presented indicating that a sufficient intake of a carboxylic cation exchanger in the potassium cycle increases the stool output of sodium in absolute as well as in relative terms (1)(2)(3)(4). Two other findings accompanying the use of this form of the resin are noteworthy: a) a significant proportion of the potassium taken with or as part of the resin can be retained in the body and b) ingestion of this particular resin does not produce acidosis. Its efficiency in removing sodium is probably not as great, however, as that of either the hydrogen or the ammonium forms of the resin, each of which interferes with potassium absorption and induces a metabolic acidosis. The first half of this paper deals with findings observed during the simultaneous administration of the two types of resin in equal proportions, i.e., potassium cycle mixed with either the hydrogen or the ammonium cycle, as well as in mixtures in which the acidifying resin predominated.The second half of this report describes results obtained during the use of resin mixtures with ACTH or cortisone or both. The expanding recourse to adrenal cortical effects in the therapy of a wide variety of disease states (5-7) has further emphasized that prolonged therapy is frequently not possible because of two particularly undesirable concomitants, i.e., sodium retention and potassium depletion. It seems probable that these side effects by necessitating interruption or intermittency of treatment deprive patients of benefits which might be otherwise obtainable. The combined resin and steroid or hormone studies herein presented describe attempts at prevention or deferment of such deviations in cation metabolism. MATERIALS AND METHODSEqual parts of the acidifying and non-acidifying exchange resins were administered in capsules for a daily total of 24 to 60 g. to hospitalized children or adults during 16 periods three to seven days in length. Mixtures preponderating in the acidifying resin, i.e., 75 to 80% in the ammonium or hydrogen cycle, were given in eight subsequent studies in four patients. In the final group of experiments four parts of ammonium or hydrogen form resin and one part of the potassium resin were administered to patients undergoing treatment with adrenocorticotrophic hormone or cortisone. In all three groups of studies control periods were included when possible. The experimental procedures and other pertinent information have been described earlier (1, 2). The dietary regimens employed, the results of blood and serum analyses, and the available balance data are presented in tabular form. To assist interpretation the findings have been expressed statistically wherever possible and presented in graphic form. RESULTS

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Section: Resultsmentioning

confidence: 82%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Acidifying and Non-Acidifying Carboxylic Resin Mixtures Used Alone and With Acth or Cortisone

Peters¹,

Danowski²,

Greenman³

et al. 1951

J. Clin. Invest.

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“…Attempts to maintain the daily intake of the resin at 30 to 40 g., amounts readily taken by essentially healthy children in control studies (20), were only partially successful. As a result the mean daily intake proved to be only 17.7 + S.D.…”

Section: Resultsmentioning

confidence: 99%

“…Changes during and following resin therapy have been compared with those observed in the same subjects during control periods on sodium restriction alone. Balance procedure, analytical techniques and methods of calculation have been described earlier (20)(21)(22)(23).…”

Section: Methodsmentioning

confidence: 99%