Biochemical changes and oxidative stress induced by zearalenone in the liver of pregnant rats

Abstract

<jats:p> The aim of the present research was to examine the toxic influence of different doses of zearalenone (ZEN) on the liver, especially oxidative stress induced by ZEN on the liver. A total of 48 pregnant Sprague-Dawley rats were randomly assigned into 4 treatments groups with 12 animals in each. The rats were fed with a normal diet treated with 0 mg/kg (control), 50 mg/kg (treatment 1), 100 mg/kg (treatment 2), or 150 mg/kg (treatment 3) ZEN in feed on gestation days (GDs) 0–7 and then all the rats were fed with a normal diet on GDs 8–20. The experimental period lasted 21 days. The results showed that exposure to ZEN induced increase in aspartate amino transferase, alanine aminotransferase, and alkaline phosphatase activities and decrease in total protein and albumin content in a dose-dependent manner and also induce decrease in superoxide dismutase and glutathione peroxidase activities and increase in malondialdehyde content in a dose-dependent manner in the serum and the liver. The increased transcription of cytochrome P450 2E1 (CYP2E1) was detected in the liver after exposure to ZEN. These results suggested that ZEN not only caused damage in the liver of pregnant rats in a dose-dependent manner but also induced the messenger RNA expression of CYP2E1 in the liver. </jats:p>

Lycopene protects against acute zearalenone-induced oxidative, endocrine, inflammatory and reproductive damages in male mice

“…Our study indicated that ZEA induced oxidative stress in testicular tissue as manifested by the modulation of GSH systems (GPx, GR and GST enzymes and GSH/GSSG levels). These results concurred with previous studies [8,9,43,44]. Importantly, GST expression in testes was not modified and the activity of this enzyme was inhibited.…”

“…Therefore, these interleukins at pathological concentrations in the testis may injure the seminiferous epithelium, elevate the sensitivity and trigger some inflammation [49]. In accordance with the present findings, previous studies showed that exposure to ZEA also induced an intense inflammatory reaction as manifested [43][44][45]. These effects may help explain that the testicular immune structure could be disturbed by mycotoxins, such as ZEA.…”

Oxidative Stress Induced by Zearalenone in Porcine Granulosa Cells and Its Rescue by Curcumin In Vitro

“…Previous studies show that ZEA exists in the contaminated livestock feed and food, and potentially impacts human and animal health [ 39 – 43 ]. For domestic animals, ZEA seriously interferes with their reproduction [ 40 – 42 ] and induces oxidative stress as a result of decreased antioxidative enzymes [ 44 , 45 ]. However, no detailed information regarding ROS induced by ZEA in porcine granulosa is available, and the rescue of the oxidative stress has not been attempted.…”

Crocin and Quercetin protect HCT116 and HEK293 cells from Zearalenone-induced apoptosis by reducing endoplasmic reticulum stress

“…Indeed, different reports have demonstrated that ZEN induces ROS production (Bouaziz et al 2009;Jia et al 2014;Zhou et al 2015) and lipid peroxidation in vitro and in vivo and can engender oxidized DNA bases (Abid-Essefi et al 2004;Hassen et al 2007;Abbes et al 2007). Results of our study provide evidence that ZEN triggers ROS generation in HCT116 and HEK293 cells.…”