Biochemical changes in alcoholic hepatitis with phyllanthus amarus therapy: A study

Abstract

Alcoholic hepatitis is a leading cause of morbidity and mortality. This study focuses on PhyllanthusAmarus therapy and its effect on liver in alcoholic hepatitis. The therapy tries to protect the liver by investigating liver profile enzymes, antioxidant enzymes, antioxidant vitamins and lipid peroxidation. The study consists of 50 well diagnosed alcoholic hepatitis males aged between 33 to 55 years. The control group includes 50 age-matched normal healthy persons. Oxidative stress was assessed by estimating lipid peroxidation [LPO]. Parameters like serum bilirubin, total proteins and activity of liver profile enzymes were chosen. The activity of enzymatic antioxidants, superoxide dismutase [SOD], glutathione peroxidase [GPx], catalase, and levels of non-enzymatic antioxidant vitamin E and vitamin C were measured in plasma or erythrocytes. Methods used in the study are mainly enzyme kinetics by auto-analyzer and turbidimetry. Plasma LPO levels were significantly high but activity of SOD, GPx, catalase, and levels of vitamin E and vitamin C were significantly lowered in alcoholic hepatitis when compared with controls. After phyllanthus amarus therapy, for four and eight weeks, plasma LPO levels significantly decreased and activity of SOD, GPx, catalase and levels of vitamin E and C significantly increased in alcoholic hepatitis. This study concludes that the imbalance between oxidative stress and anti-oxidants may play an important role in alcoholic hepatitis. Elevated free radicals may cause hepatic cell loss and play a role in pathogenesis of alcoholic hepatitis. This study strongly suggests that the therapy of phyllanthus amarus increases activity antioxidants and reduces lipid peroxidation; protects liver from damage due to free radicals in alcoholic hepatitis.

Ginseng Berry Prevents Alcohol-Induced Liver Damage by Improving the Anti-Inflammatory System Damage in Mice and Quality Control of Active Compounds

“…An increase in the level of serum enzymes, such as AST, ALT, and LDH, a biomarker of liver damage, is indicative of the dysfunction of hepatocytes and collapse of functional structure of cell membrane in the liver. Injury of liver tissue also results in the leaking of cellular enzymes of damaged hepatocytes into serum [29]. Superoxide dismutase is a pivotal enzyme having antioxidant activity via scavenging superoxide anion; catalase is an enzyme responsible for the detoxification of H 2 O 2 generated by SOD, suppressing the formation of superoxide radicals [30].…”

A review on medicinal plants used in the management of liver diseases in West Africa

“…The treatment of hepatitis B patients with P. amarus significantly reduced lipid peroxidation and increased the activity of SOD, GPx (glutathione peroxidase), CAT, the level of vitamins E and C [96]. Aqueous extracts of P. amarus roots showed significant activity against bovine viral diarrhea virus, a surrogate for hepatitis C virus [97].…”

A Robótica Como Estratégia No Desenvolvimento Das Habilidades Do Indivíduo Com Transtorno Do Espectro Autista

“…Este efeito protetor de P. amarus pode ser devido à presença de quercetina e rutina (flavonóides), filantina e hipofilantina (lignanas), saponinas e compostos fenólicos (ácido gálico). O efeito cardioprotetor exibido pelo extrato sugere o seu uso nos cuidados de DCV (doença venosa crônica) e problemas de saúde associados.A ação anti-hepatite B foi analisada porNikam, Nikam, Sontakke (2010). Os autores avaliaram o efeito da terapia com P. amarus na proteção do fígado na hepatite B, através da investigação de enzimas do perfil hepático, enzimas antioxidantes, vitaminas antioxidantes e peroxidação lipídica (LPO).…”