Biochemical characterisation of the neuraminidase pool of the human gut symbiont Akkermansia muciniphila

Huang, Kun; Wang, Mao M.; Kulinich, Anna; Yao, Hong; Hong, Yang; Martínez, Juana Elizabeth Reyes; Duan, Xu; Chen, Huan; Cai, Zhi Peng; Flitsch, Sabine L.; Liu, L.; Voglmeir, Josef

doi:10.1016/j.carres.2015.08.001

Cited by 69 publications

(43 citation statements)

References 36 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sialic acid is one the outermost carbohydrate decorations of mucin. Akkermansia can cleave sialic acids: Its genome encodes four neuraminidase enzymes responsible for the removal of sialic acids from glycoconjugates (Huang et al, 2015). SIGLEC15 is expressed on macrophages and DCs in humans, and is reported to be expressed in ileum tips in mice (Sommer et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Genetic Determinants of the Gut Microbiome in UK Twins

Goodrich

Davenport

Beaumont

et al. 2016

Cell Host & Microbe

904

875

View full text Add to dashboard Cite

Summary Studies in mice and humans have revealed intriguing associations between host genetics and the microbiome. Here we report a 16S rRNA-based analysis of the gut microbiome in 1,126 twin pairs, a subset of which was previously reported. Tripling the sample narrowed the confidence intervals around heritability estimates and uncovered additional heritable taxa, some of which are validated in other studies. Repeat sampling of subjects showed heritable taxa to be temporally stable. A candidate gene approach uncovered associations between heritable taxa and genes related to diet, metabolism and olfaction. We replicate an association between Bifidobacterium and the lactase (LCT) gene locus and identify an association between the host gene ALDH1L1 and SHA-98 bacteria, suggesting a link between formate production and blood pressure. Additional genes detected are involved in barrier defense and self/non-self recognition. Our results indicate that diet-sensing, metabolism, and immune defense are important drivers of human-microbiome co-evolution.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetic Determinants of the Gut Microbiome in UK Twins

Goodrich

Davenport

Beaumont

et al. 2016

Cell Host & Microbe

904

875

View full text Add to dashboard Cite

show abstract

“…A. muciniphila has been classified as the sole gram-negative emblematic Verrucomicrobia (Belzer and De Vos, 2012), which is extensively present in the human intestinal mucosa (Huang et al, 2015). Since Derrien et al (2004) identified the type strain of A. muciniphila as MucT (ATCC BAA-835 1/4 CIP107961T) (Zhai et al, 2018), gene sequencing analysis has shown that there are a lot of mucinase-encoding gene candidates and that its single chromosome contains 2176 genes with a 55.8 percentage of GC content.…”

Section: Introductionmentioning

confidence: 99%

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

et al. 2020

View full text Add to dashboard Cite

Obesity and its metabolic syndrome, including liver disorders and type 2 diabetes, are a worldwide epidemic and are intimately linked to diet. The gut microbiota interaction has been pointed to as a hot topic of research in the treatment of obesity and related metabolic diseases by influencing energy metabolism and the immune system. In terms of the novel beneficial microbes identified, Akkermansia muciniphila (A. muciniphila) colonizes the mucosa layer of the gut and modulates basal metabolism. A. muciniphila is consistently correlated with obesity. The causal beneficial impact of A. muciniphila treatment on obesity is coming to light, having been proved by a variety of animal models and human studies. A. muciniphila has been characterized as a beneficial player in body metabolism and has great prospects for treatments of the metabolic disorders associated with obesity, as well as being considered for next-generation therapeutic agents. This paper aimed to investigate the basic mechanism underlying the relation of A. muciniphila to obesity and its host interactions, as identified in recent discoveries, facilitating the establishment of the causal relationship in A. muciniphila-associated therapeutic supplement in humans.

show abstract

“…This gene is critical in differentiating between self and non self in autoimmune reactions against self-antigens. 69 A similar association between Akkermansia and the phospholipase D1 (PLD1) gene, expressed in intestinal villi, was also determined in the Hutterites. 70 Although associations between genetic factors, microbiome, and drug response have been minimally investigated in cancer subjects, key studies have suggested causal relationships between microbial drug metabolism, efficacy, and toxicity.…”

Section: Impact Of Host Genetics On Gut Microbiome and Drug Metabolismmentioning

confidence: 67%

“…In the TwinsUK cohort, an association between Akkermansia and the SIGLEC15 gene, which encodes for sialic acid binding immunoglobulin‐like lectin, was identified. This gene is critical in differentiating between self and non self in autoimmune reactions against self‐antigens . A similar association between Akkermansia and the phospholipase D1 ( PLD1 ) gene, expressed in intestinal villi, was also determined in the Hutterites …”

Section: Impact Of Host Genetics On Gut Microbiome and Drug Metabolismmentioning

confidence: 71%

Pharmacomicrobiomics: The Holy Grail to Variability in Drug Response?

Sharma

Buschmann

Gilbert

2019

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

The human body, with 3.0 × 1013 cells and more than 3.8 × 1013 microorganisms, has nearly a one‐to‐one ratio of resident microbes to human cells. Initiatives like the Human Microbiome Project, American Gut, and Flemish Gut have identified associations between microbial taxa and human health. The study of interactions between microbiome and pharmaceutical agents, i.e., pharmacomicrobiomics, has revealed an instrumental role of the microbiome in modulating drug response that alters the therapeutic outcomes. In this review, we present our current comprehension of the relationship of the microbiome, host biology, and pharmaceutical agents such as cardiovascular drugs, analgesics, and chemotherapeutic agents to human disease and treatment outcomes. We also discuss the significance of studying diet–gene–drug interactions and further address the key challenges associated with pharmacomicrobiomics. Finally, we examine proposed models employing systems biology for the application of pharmacomicrobiomics and other ‐omics data, and provide approaches to elucidate microbiome–drug interactions to improve future translation to personalized medicine.

show abstract

Biochemical characterisation of the neuraminidase pool of the human gut symbiont Akkermansia muciniphila

Cited by 69 publications

References 36 publications

Genetic Determinants of the Gut Microbiome in UK Twins

Genetic Determinants of the Gut Microbiome in UK Twins

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

Pharmacomicrobiomics: The Holy Grail to Variability in Drug Response?

Contact Info

Product

Resources

About