Biochemical characterization of microcystin toxicity in rainbow trout (Oncorhynchus mykiss)

Tencalla, Francesca G.; Dietrich, Daniel R.

doi:10.1016/s0041-0101(96)00153-5

Cited by 156 publications

(140 citation statements)

References 37 publications

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“…The MC concentrations in the livers of the four fish species studied here were all relatively low, which contradicts the results of previous studies (Kankaanpää et al, 2005;Li et al, 2004;Malbrouck et al, 2003;Xie et al, 2005). The liver is an important detoxification organ, and bile plays an important role in the elimination and recirculation of excess MCs from the fish liver (Tencalla and Dietrich, 1997). This is the first study to examine the accumulation of MCs in the heart tissue of wild fish.…”

Section: Discussioncontrasting

confidence: 98%

“…The population density of the cyanobacteria at MLB (3.24 × 10 7 cell/L) was higher than that at other locations, such as WC, where it was 3.05 × 10 7 algae cell/L, SC (1.85 × 10 7 algae cell/L) and LC (1.77 × 10 7 algae cell/L) (Authority, 2011). The importance of the liver as an elimination and recirculation organ for MCs (Tencalla and Dietrich, 1997) suggests that liver MC accumulation is related to algal cell density in the water column. Fish from LC had the highest mean concentrations of MCs in the muscle, kidneys and hearts.…”

Section: Discussionmentioning

confidence: 99%

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Bioaccumulation of microcystins (MCs) in four fish species from Lake Taihu, China: Assessment of risks to humans

Jia

Luo

Lü

et al. 2014

Science of The Total Environment

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Microcystins (MCs) are the toxic products of harmful algal blooms and they accumulate in fish. The accumulation of MCs in fish living in different trophic levels from different parts of Lake Taihu was determined. This information was then used to evaluate the risks posed by the MCs in fish to human health. The concentrations of three MCs, MC-LR, MC-YR and MC-RR, were quantified in the following four fish species: silver carp (Hypophthalmichthys molitrix), bighead carp (Aristichthys nobilis), crucian carp (Carassius auratus) and common carp (Cyprinus carpio), using high performance liquid chromatography interfaced with tandem (triple quadrupole) mass spectrometry. The mean concentrations of MCs in the muscle, the kidney, the intestinal wall and the heart were significantly different among the four fishes except in the liver. C. carpio contained the highest mean concentration of MCs in the muscle (31.7 ± 12.1 ng/g, dry mass (dm)), whereas C. auratus had the highest mean concentrations of MCs in the liver (45.4 ± 44.5 ng/g, dm), kidney (114 ± 51.1 ng/g, dm), intestinal wall (2.04 × 10 3 ± 4.43 × 10 3 ng/g, dm) and heart (59.5 ± 26.7 ng/g, dm). The mean concentration of MCs in the intestinal walls of the fish species was significantly higher than in other organs (p b 0.01). The fish from Meiliang Bay had significantly higher concentrations of MCs than those from the centre, west or south banks of the lake (p b 0.01). The body lengths and masses of the fish were negatively correlated with the concentrations of MCs in the kidney (p b 0.05) and heart (p b 0.01). The average daily intake (ADI) of MCs in the muscle of all fishes exceeded the provisional tolerable daily intake (TDI) set by World Health Organization. The estimated daily intakes of MCs in 55.6% of the muscle samples exceeded the TDI. The MCs in the tissues of the fish from Lake Taihu pose potential risks to the health of humans who consume these four fish species.

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Section: Discussioncontrasting

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Bioaccumulation of microcystins (MCs) in four fish species from Lake Taihu, China: Assessment of risks to humans

Jia

Luo

Lü

et al. 2014

Science of The Total Environment

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“…However, increased MC-RR-Cys was observed from 0.008 ± 0.001 to 0.037 ± 0.011 g mL −1 . These results indicate that MC-RR and its metabolites may be readily transported into intestines for excretion or recirculation from liver via bile salts, as previous studies have shown that microcystins transport into cells is probably involved in the bile salt transport system [31,32].…”

Section: Tablesupporting

confidence: 63%

Quantitative liquid chromatography–tandem mass spectrometry method for determination of microcystin-RR and its glutathione and cysteine conjugates in fish plasma and bile

Xie

et al. 2014

Journal of Chromatography B

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“…Previous studies demonstrated that cyanobacterial exposure through the gastrointestinal system was toxic to many fish species such as rainbow trout (Tencalla et al, 1996), common carp , silver carp (Xie et al, 2007), and tilapia (Mohamed et al, 2003;Mohamed and Hussein, 2006). Previous studies reported that fish exposed to or feeding on toxic cyanobacterial cells showed a reduced growth (Bury et al, 1995;Kamjunke et al, 2002a,b).…”

Section: Effect Of Dietary Cyanobacteria On Fish Growth and Feed Utilmentioning

confidence: 99%

“…Faced with chronic exposure of cyanobacteria, fish are not able to avoid exposing to MCs through food in those waters such as small eutrophic lakes and aquaculture ponds (Tencalla and Dietrich, 1997;Magalhães et al, 2001). However, little information is available on the chronic or subchronic effect of cyanobacteria on fish via oral route Zhao et al, 2006;Dong et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

Dong

Zhu

Han

et al. 2011

Environmental Toxicology

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A 90-day growth trial was conducted on hybrid sturgeon (Acipenser baeri $ 3 A. gueldenstaedtii #) to investigate the effect of dietary inclusion of cyanobacteria on growth, feed utilization, and fish tissue microcystins (MCs) accumulation and the recovery of fish when they were free of cyanobacteria. Four diets were formualted isonitrogenous and isocaloric to contain different MCs concentrations: the control diet (free of cyanobacteria), low cyanobacteria diet (LCD, 26.60 lg MCs/g diet), medium cyanobacteria diet (MCD, 78.82 lg MCs/g diet), and high cyanobacteria diet (HCD, 201.03 lg MCs/g diet). During the first 47 days, each diet was fed to fish in five replicates and then all fish were fed the control diet during the next 43 days. The results showed that a dose-dependent decrease in feeding rate (FR) and specific growth rate (SGR) were observed in the fish fed with MCD and HCD. MCs contents in fish liver, intestine, and dorsal white muscle increased with dietary MCs and were time dependent (P \ 0.05). After the 43-day recovery, there were no significant differences in FR or SGR between the fish previously fed LCD or MCD and the fish fed with the control diet (P [ 0.05), while the fish previously fed HCD showed higher FR and SGR than those fed the control diet (P \ 0.05). MCs clearance in fish liver and intestine showed time-dependence during the 43-day recovery. # 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 161-170, 2011.

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Biochemical characterization of microcystin toxicity in rainbow trout (Oncorhynchus mykiss)

Cited by 156 publications

References 37 publications

Bioaccumulation of microcystins (MCs) in four fish species from Lake Taihu, China: Assessment of risks to humans

Bioaccumulation of microcystins (MCs) in four fish species from Lake Taihu, China: Assessment of risks to humans

Quantitative liquid chromatography–tandem mass spectrometry method for determination of microcystin-RR and its glutathione and cysteine conjugates in fish plasma and bile

Response and recovery of hybrid sturgeon from subchronic oral administration of cyanobacteria

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