Biochemical Composition and Anticancer Effect of Different Seaweed  Species (In-vitro and In-vivo Studies)

Ranahewa, T.H.; Premarathna, Amal D; Wijesundara, R.M. K.K.; Wijewardana, Viskam; Jayasooriya, Anura P.; Rajapakse, Jayanthe

doi:10.36956/sms.v1i2.94

Cited by 8 publications

(8 citation statements)

References 28 publications

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“…Seaweeds have been known to contain bioactive compounds 5 that are derived from sulfated polysaccharides, polyphenols, carotenoids, proteins and lipids 6 . Seaweeds have demonstrated anti-inflammatory 7 , wound healing 8 , 9 , anti-cancer 10 , anti-diabetic activities, and anti-degenerative activities 6 . Isolated compounds of seaweeds have been subjected to clinical trials to investigate their potential drug abilities in the field of oncology 11 .…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of proximate compositions, mineral and functional chemical groups of 15 different seaweed species

Premarathna

Tuvikene

Fernando

et al. 2022

Sci Rep

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Seaweed is a popular edible source and is associated with many foods and pharmaceutical industries around the world. The current research aims to provide information on the chemical composition of 15 seaweed species, consisted of Chlorophyta, Ochrophyta/Phaeophyceae, and Rhodophyta macroalgae, collected from coastal areas of Sri Lanka. Seaweed samples were subjected to the analysis of lipids, proteins, ash and macro, micro, trace and ultra-trace elements. The highest protein content was recorded in the brown algae. Maximum dietary fiber and ash contents were recorded from green algae. The highest predominant fatty acids were observed from green seaweeds (Caulerparacemosa); however, linoleic acid (C18:2n6) is the dominant fatty acid of all macroalgae. Mineral contents were highest in the red macroalga; however, copper, zinc and magnesium were also comparatively higher in green alga Ulvalactuca. In conclusion, 15 seaweed species belonging to the three different classes of seaweeds are investigated in details to obtain their biochemical, mineral and fatty acid compositions for the synthesis of novel therapeutic agents. In order to explore biorefinery processes for these seaweeds, as well as how they can potentially be cultivated, more extensive studies are required. Studying and determining the nutritional values of seaweeds will be beneficial with the potentials for future industrial uses and research.

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Section: Introductionmentioning

confidence: 99%

Comparative analysis of proximate compositions, mineral and functional chemical groups of 15 different seaweed species

Premarathna

Tuvikene

Fernando

et al. 2022

Sci Rep

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“…Nevertheless, a wide range of anti-inflammatory, antibiotic, anti-HIV, anticoagulant, anticonvulsant [ 10 ], antineoplastic, antiulcer [ 11 ], and antimicrobial activities of seaweeds have also been reported [ 12 ]. Also, seaweeds are comprised of bioactive compounds that are capable of producing a great variety of secondary metabolites with broad biological activities [ 13 , 14 ]. The seaweeds can also be used to prevent tissue damage and stimulate the wound healing process [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of the wound healing properties and safety assessment of two seaweeds (Sargassum ilicifolium and Ulva lactuca)

Premarathna

Wijesekera

Jayasooriya

et al. 2021

Biochemistry and Biophysics Reports

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Seaweeds have been regarded as a reservoir of biologically active molecules that are important in the pharmaceutical industry. The aim of the present study was to explore the wound healing properties and to assess the safety of the seaweed Sargassum ilicifolium and Ulva lactuca. Enhanced cell proliferation and cell migration activities were observed in L929 cells treated with S. ilicifolium extract compared to U. lactuca extract treated cells and the control group. In-vivo experiments were conducted using five groups (10 in each) of Albino mice (BALB/c). Mice in group I and group II were treated (Orally, 100 mg/kg BW/day) with aqueous extracts of S. ilicifolium and U. lactuca , respectively for 14 days. Treatment group III received a topical application of the aqueous extract of S. ilicifolium (25% w/w) and ointment base (75% w/w) (2 g/kg BW/day, for 14 days). Group IV (Control) received an equal amount of distilled water, orally and mice in group V kept without wounds. The extract from S. ilicifolium showed stronger wound healing properties than the one from Ulva lactuca . Histopathological findings also revealed that the healing process was significantly enhanced in the mice group treated orally with S. ilicifolium aqueous extract. These findings show that S. ilicifolium species possess promising wound healing properties in-vitro and in-vivo .

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“…Docking is habitually utilized for evaluating the binding between the ligand and the receptor 23 . However, the previous studies indicated the antibacterial, antioxidant and anti-cancerous properties of this seaweed in the ethanol extract [24][25][26] but the present study aimed at determining numerous phytochemical compounds responsible for breast cancer through insilico methods. It is well-known that mutated domains are accountable for the cancer progression, and rendering to the Database of Cancer Mutant proteins database(DCMP) BRCA1 C-terminal (BRCT) domains are vital signalling elements in the DNA damage response.…”

Section: Introductionmentioning

confidence: 96%

Unravelling the Antioxidant and Anti-Cancerous Properties of the Chemical Constituents Present in Methanol Extract of Green Algae Chaetomorpha Antennina

Dubey

Jayanthi

2022

Bulletin of Pharmaceutical Sciences. Assiut

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Background: Chaetomorpha antennina is a green seaweed with numerous pharmacological properties such as antimicrobial, antimalarial, anti-tumour and antioxidant properties. Thus, it is essential to perform preliminary studies to identify the chemical composition of seaweed extracts and explore the phytoconstituent responsible for pharmacological activities. Cancer is the leading cause of death worldwide. The discovery of novel therapeutic mediators for the treatment of cancer is the main task. Since efficient drug delivery is possible through nanotechnology, biosynthesis of silver nanoparticles was done, followed by molecular docking studies to investigate the anti-cancer activity of seaweed extract.Methods: Phytochemical analysis of extracts of Chaetomorpha antennina was performed, followed by biosynthesis of silver nanoparticles using these algal extracts. Characterization of silver nanoparticles was done by Scanning Electron Microscopy and X-ray Diffraction. Agar-well diffusion method and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay were used to determine the antibacterial potential and antioxidant potential of algal extracts. Further, the chemical composition of the extract was distinguished by Gas chromatography-mass spectrometry.Results: Seaweed extracts possessed numerous phytochemicals and methanol extract showed the best antibacterial and antioxidant activity. Docking studies exposed the occurrence of Carpesterol dehydrate and triazines as an anti-cancer component of Chaetomorpha antennina. Conclusion: It can be concluded that seaweed is enriched with chemical constituents possessing high antioxidant activity and therefore, can serve as a promising antioxidant and anti-cancer agent.

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Biochemical Composition and Anticancer Effect of Different Seaweed Species (In-vitro and In-vivo Studies)

Cited by 8 publications

References 28 publications

Comparative analysis of proximate compositions, mineral and functional chemical groups of 15 different seaweed species

Comparative analysis of proximate compositions, mineral and functional chemical groups of 15 different seaweed species

In vitro and in vivo evaluation of the wound healing properties and safety assessment of two seaweeds (Sargassum ilicifolium and Ulva lactuca)

Unravelling the Antioxidant and Anti-Cancerous Properties of the Chemical Constituents Present in Methanol Extract of Green Algae Chaetomorpha Antennina

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