Biochemical consequences of lipid peroxidation

Bland, Jeffrey

doi:10.1021/ed055p151

Cited by 25 publications

(11 citation statements)

References 51 publications

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“…Dense granules exhibited peroxidase activity [5], contained calcium ions, cAMP, ATP, ADP, catecholamines (epinephrine and norepinephrine) and biogenic amine (serotonin) [1]. High concentration of serotonin in dense granules is due to the presence of its highmolecular-weight complexes.…”

Section: Resultsmentioning

confidence: 99%

Protective characteristics of platelets in tuberculosis

Khechinashvili

Khvitiya

2004

Bull Exp Biol Med

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We demonstrated specific changes in platelet structure in different types of tuberculous process, in particular, shift in the proportion between alpha-granules, dense granules, different disorders in the mitochondrial and lysosomal apparatus, etc. The role of platelets in immune process is studied. Redistribution of alpha-granules in platelets finds a new interpretation in light of psycho- and neurotropic effects of their contents. Adhesion and aggregation processes and granule release from platelets are regulated by the content of serotonin and cyclic nucleotides in these cells.

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Section: Resultsmentioning

confidence: 99%

Protective characteristics of platelets in tuberculosis

Khechinashvili

Khvitiya

2004

Bull Exp Biol Med

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“…hydroxyl ºOH, NO peroxynitrite ºONO 2 , nitroxyl RNOº, phenoxyl, alcohoxile RCO, peroxyl RCOOº the among other highly reactive polyunsaturated fatty acids in the membranes of cells producing the peroxyl radical primary product of lipid peroxidation in the presence of a reducing agent as hydroperoxide [48] whose decomposition gives rise to malondialdehyde and 4 hydroxy alquenal, Figure 5, that bind to RSH 2 of the amino acids in proteins and DNA thymine which metal ions (trace elements) can lead to mutations [49].…”

Section: It Is Very Obvious That the Balance Between Hydrolysis And Smentioning

confidence: 99%

Alternative Medicine and Molecular Mechanisms in Chronic Degenerative Diseases

Velázquez¹,

Beltrán²,

Panduro³

et al. 2011

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Knowledge of healing plants worldwide properties it has been extensively studied by their biological activities. The increasing number of plant users for healthcare originated the Research Center in Complementary Alternative Medicine, National Institute of Health (NIH) whose primary function is to be alert with a strictly scientific sense about de use of plants as main source of Complementary Alternative Medicine. It is currently about the synergy known that Is achieved on the hepatoprotective, antioxidant and hypoglycaemic activities with mixtures formed by selected plants and combined. These plants are characterized by their content of hidroxyphenolic compounds as cynarin, rosmarinic acid, flavonoids silybin and among others. Actually this kind of herbal preparations are investigated in patients with cirrhosis, type II diabetes mellitus, breast cancer and arthritis diseases. Patients with Chronic Degenerative Diseases are in state of stress and Its metabolism produces free radicals such as superoxide ºO<sub>2</sub>, hydroxyl ºOH and peroxynitrite highly reactive with unsaturated fatty acids of cell membranes producing lipid peroxidation. The main product of this process is the peroxyl, that when it’s reduced forms hydroxiperoxyle its decomposition forms MDA and 4-hidroxialquenal. These substances bind to R-SH<sub>2</sub> of the aminoacids of the proteins and to the thymine of DNA, altering their biological function. Before the treatments with selected and micropulverized plants to patients, it is necessary and required in animal models demonstrate that plants do not produce toxic effects. Using mixtures of plants micropulverized is good choice because these microparticles behave as micro-releasing their constituents with increased activity and bioavailability to target cells so it will be possible to achieve greater power to control their activity and perhaps cure the disease, and provide patients an effective herbal medicine safe, free of toxic effects and low cost

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“…Oxidation of active methylene compounds is important in the in vivo metabolic process catalyzed by oxygenase as well as in organic synthesis 236 . Various substrates containing a benzylic methylene group were readily reacted with 51 at −35 • C to give the corresponding carbonyl compounds in excellent yields.…”

Section: Sulfonylperoxy Radicalmentioning

confidence: 99%