Biochemical Effects of Lead Exposure on Battery Manufacture Workers with Reference to Blood Pressure, Calcium Metabolism and Bone Mineral Density

Dongre, Nilima N.; Suryakar, Adinath N.; Patil, Arun T.; Hundekari, Indira A.; B.B.Devarnavadagi,

doi:10.1007/s12291-012-0241-8

Cited by 62 publications

(61 citation statements)

References 22 publications

(21 reference statements)

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“…Moreover, a decreased serum calcium and phosphorus levels were observed following lead toxicity. This result was in parallel with Dongre et al, (2013) who revealed that lead can inhibit calcitriol synthesis which decrease calcium absorption at intestinal and renal level causing hypocalcemia and hypophosphatemia. Coadministration of alpha lipoic acid together with lead acetate didn′t alter hepatic lead concentration; however increase hepatic iron and decrease copper levels with increasing serum calcium and phosphorus levels.…”

Section: Discussionsupporting

confidence: 72%

Anti-Oxidative Role Of Lipoic Acid Against Lead-Induced Hepatic Toxicity In Japanese Quails

Ismail¹,

Taha²,

Mandour³

et al. 2017

AJVS

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Key words:Quails; Lead; Lipoic acid; Antioxidant; Malondialdehyde, Copper Quails are exposed to deleterious doses of lead from different sources which decrease the bird performance, and growth with economic loses. This work aimed to explore the antioxidative effect of alpha lipoic acid to counteract the adverse effects of lead in Japanese quails. Forty Japanese quails with both sex were grouped into control, lead acetate (100 ppm in drinking water), alpha lipoic acid (1 g/kg diet), and the final group which received both lipoic acid and lead acetate of the same doses. Lead acetate significantly increased the liver enzymatic biomarkers (ALT, AST, and ALP), and bilirubin levels with decline in the serum total protein and albumin concentrations. Also, lead, copper concentrations in liver tissue were significantly increased with decreased hepatic iron level and serum calcium and phosphorus levels following lead acetate administration. Moreover, lead significantly increased hepatic malondialdehyde level with attenuation of antioxidant enzymes; GPX, GST, CAT, and SOD activities and nonenzymatic antioxidant; GSH concentration. Co-administration of alpha-lipoic acid together with lead acetate significantly improved the liver functions, increased the antioxidant activities, and corrected the serum and hepatic major and trace element concentrations without any effect on hepatic lead level. Our results suggested that alpha lipoic acid can counteract the deleterious effects of lead in quails through attenuation of oxidative stress and enhancement of antioxidative capacity in liver tissues.Correspondence to:

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Section: Discussionsupporting

confidence: 72%

Anti-Oxidative Role Of Lipoic Acid Against Lead-Induced Hepatic Toxicity In Japanese Quails

Ismail¹,

Taha²,

Mandour³

et al. 2017

AJVS

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“…After chelation therapy with dimercaptosuccinic acid, complete recovery of hyperpigmentation, itching, and thrombo-cytosis was noted 17. Dongre et al showed that in the battery manufacture, workers with lead exposure had high blood pressure, disturbed calcium and phosphorous metabolism, and skin itching 18. In the surveys of drinking water polluted by lead in Kerou and So-ava, people who consumed lead-polluted water had various symptoms including skin itching 19,20.…”

Section: Discussionmentioning

confidence: 99%

Blood lead level is a positive predictor of uremic pruritus in patients undergoing hemodialysis

Weng

Hsu

et al. 2017

TCRM

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Although uremic pruritus (UP) is a common and annoying symptom for end-stage renal disease patients on hemodialysis (HD) and peritoneal dialysis, its pathogenesis is poorly understood. However, systemic inflammation is one of the possible pathogenesis of UP, and blood lead level (BLL) has been noted to be associated with inflammation and nutritional status in long-term HD patients. There might be an interaction or association, therefore, between BLL and UP through systemic inflammation. We analyzed cross-sectional data among 866 participants. All of the 866 patients in this study were stratified into groups with low-normal (<10 μg/dL), high-normal (10–20 μg/dL), and abnormal BLLs (>20 μg/dL). The associations between UP and BLL and the clinical data were analyzed. Multivariate logistic regression demonstrated that HD duration, non-anuria, log ferritin, serum low-density lipoprotein, log BLL, high-normal BLL, and high BLL were associated with UP. In conclusion, BLL was positively associated with UP.

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“…One of the toxic mechanisms of Pb on the molecular machinery of living organisms is its covalent binding to the Ca carrier proteins albumin and calmodulin, oxidative damage to cell membranes (Gurer-Ohrnan et al, 2004) and close interaction on stereospecific sites for cations such as Ca 2+ in bones (Garza et al, 2006). The causes of hypocalcaemia in lead-exposed patients are complex and multifaceted, some of which include; competitive binding to the Careceptor sites at the epithelial surfaces of small intestine, thus, reducing Ca absorption (Bodgen et al, 1995), negative Ca balance arising from Pb inhibition of the activation of vitamin D in the renal cortex (Chichovska & Anguelov, 2006;Gavazzo et al, 2008;Herman et al, 2009), hypoalbuminaemia, renal impairment and depressive effect of Pb on parathyroid function (Kristal-Boneh et al, 1998;Pekcici et al, 2010;Dongre et al, 2013) and increased intracellular accumulation of Ca due to leadinduced oxidative stress (Oyama et al, 1996;Rajanna et al, 1996). Reduction in free Ca and increased intracellular Ortiz, 2004).…”

Section: Discussionmentioning

confidence: 99%

Effects of experimental lead exposure and the therapeutic effect of defatted Moringa oleifera seed meal on serum electrolytes levels of Wistar rats

Idoko¹,

Ugochukwu²,

Abalaka³

et al. 2018

Sokoto J. Vet. Sc.

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The study was conducted to evaluate changes in serum electrolytes concentrations following experimental lead acetate (Pb) exposure and the effects of treatment with defatted Moringa oleifera seed meal (DMOSM) in wistar rats. Eighty adult wistar rats divided into 5 groups of 16 per group were used for this study. Rats in group I received only distilled water, group II were administered Pb solution orally at 480 mg/kg body weight, group III were co-administered Pb and DMOSM orally at 480 mg/kg respectively, group IV were pre-administered Pb orally at 480 mg/kg for the first two weeks and then administered DMOSM orally at 480 mg/kg for the subsequent two weeks, group V received DMOSM orally at 480 mg/kg. Four rats were sacrificed weekly from each group and blood samples for serum electrolyte analysis were obtained. Phytochemical screening of DMOSM revealed the presence of alkaloids, reducing sugars, cardiac glycosides and saponins. A significant decrease (P < 0.05) in the mean serum Ca 2+ concentration in the rats in group III (1.52±0.17) was observed at week 3 compared to group IV (2.24±0.16). Mean serum concentration of PO 4 + at week 1 in rats in group III (3.62±0.15) was significantly higher (P < 0.05) compared to group IV (2.89±0.18). Similarly, serum PO 4 + level significantly rose at week 3 in group II (4.40±0.36) compared to rats in groups IV (2.61±0.11) and V (2.99±0.07) respectively. By week 4, the serum PO 4 + concentration rose significantly in the rats in group III (5.47±0.11) compared to those in group I (3.27±0.24). Mean serum concentrations of sodium (Na +), chloride (Cl-), potassium (K +) and bicarbonate (HCO 3-) were not significantly altered in all the test groups throughout the duration of the study. The result showed inability of DMOSM to mitigate Pb-induced alteration in serum Ca 2+ and PO 4 + levels in groups II and III.

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Biochemical Effects of Lead Exposure on Battery Manufacture Workers with Reference to Blood Pressure, Calcium Metabolism and Bone Mineral Density

Cited by 62 publications

References 22 publications

Anti-Oxidative Role Of Lipoic Acid Against Lead-Induced Hepatic Toxicity In Japanese Quails

Anti-Oxidative Role Of Lipoic Acid Against Lead-Induced Hepatic Toxicity In Japanese Quails

Blood lead level is a positive predictor of uremic pruritus in patients undergoing hemodialysis

Effects of experimental lead exposure and the therapeutic effect of defatted Moringa oleifera seed meal on serum electrolytes levels of Wistar rats

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