Comparative Biochemistry of Parasites 1972
DOI: 10.1016/b978-0-12-711050-9.50015-4
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Biochemical Effects of the Anthelmintic Drug Mebendazole

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1977
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Cited by 30 publications
(3 citation statements)
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“…Low affinity of tubulin for MBC is probably a common mechanism of resistance binding constant of 2.5 x 10 a liters/mol. In the last 15 years several benzimidazole compounds have been introduced as fungicides, like benomyP (29), fuberidazole (58), and thiabenda-1The following common names and abbreviations are used: benomyl, methyl 1-(butylcarbamoyl)benzimidazol-2-yl carbamate; fuberidazole, 2-(2'-furyl)benzimidazole; thiabendazole, 2-(4'-thiazolyl) benzimidazole; fenbenda-zole (66), as anthelmintics, like fenbendazole (5), mebendazole (68), parbendazole (1), and thiabenzole, methyl 5-phenylthiobenzimidazol-2-yl carbamate; mebendazole, methyl 5-benzoylbenzimidazoi-2-yl carbamate; parbendazole, methyl 5-butylbenzimidazol-2-yl carbamate; oncodazole or R 17934, methyl 5-(2-thienylcarbonyl)benzimidazol-2-yl carbamate; carbendazim or MBC, methyl benzimidazol-2-yl carbamate; SDS, so- dazole (12), or as antitumoral drug, like oncodazole or R 17934 (3,4). Structural formulas of these compounds are shown in Fig.…”
mentioning
confidence: 99%
“…Low affinity of tubulin for MBC is probably a common mechanism of resistance binding constant of 2.5 x 10 a liters/mol. In the last 15 years several benzimidazole compounds have been introduced as fungicides, like benomyP (29), fuberidazole (58), and thiabenda-1The following common names and abbreviations are used: benomyl, methyl 1-(butylcarbamoyl)benzimidazol-2-yl carbamate; fuberidazole, 2-(2'-furyl)benzimidazole; thiabendazole, 2-(4'-thiazolyl) benzimidazole; fenbenda-zole (66), as anthelmintics, like fenbendazole (5), mebendazole (68), parbendazole (1), and thiabenzole, methyl 5-phenylthiobenzimidazol-2-yl carbamate; mebendazole, methyl 5-benzoylbenzimidazoi-2-yl carbamate; parbendazole, methyl 5-butylbenzimidazol-2-yl carbamate; oncodazole or R 17934, methyl 5-(2-thienylcarbonyl)benzimidazol-2-yl carbamate; carbendazim or MBC, methyl benzimidazol-2-yl carbamate; SDS, so- dazole (12), or as antitumoral drug, like oncodazole or R 17934 (3,4). Structural formulas of these compounds are shown in Fig.…”
mentioning
confidence: 99%
“…Mebendazole, when introduced in 1972, was reported to have high activity against nematodes and cestodes in man and other mammalian hosts (VANDEN BOSSCHE 1972;VANPARIJS and TmENPONT 1973). The cestocidal activity of benzimidazoles had been known for many years (CAMPBELL 1961), early members of the series had only weak activity but sufficient action was shown by cambendazole for claims to be made against cestodes in sheep (HORAK et al 1972;AL-LEN 1973).…”
Section: Mebendazole A) Efficacymentioning
confidence: 97%
“…This drug affects glucose uptake into nematodes (Van den Bossche 1972), and has the ability to bind to tubulin and to inhibit the assembly of microtubules (Van den Bossche 1982). The differential affinity of host and parasite tubulin to MBZ could be one of the factors responsible for its selective toxicity.…”
Section: Introductionmentioning
confidence: 99%