Biochemical, Environmental, and Genetic Factors Associated with Paraoxonase (PON1) Activity

PON‐1 Activity and Plasma 8‐Isoprostane Concentration in Patients with Angiographically Proven Coronary Artery Disease

“…Conversely, overexpression of human PON-1 in transgenic mice results in reduction of aortic lesion size and corresponding decreases in oxidized lipid-protein adduct levels [ 12 , 13 ]. It has been shown that PON-1 activity is associated with accelerated atherosclerosis [ 14 ] but is also affected both by genetic polymorphism and by environmental factors including age, lifestyle, and pharmaceutical intervention [ 15 , 16 ].…”

The influence of gene polymorphisms, modifiable lifestyle factors, and toxicants on the protective effects of the paraoxonase genes

“…In the PON2 gene, a Ser-Cys substitution at position 311 has been found to be influential (S 311 C) (Lazaros et al, 2011;Leus et al, 2001). PON1 serum activity levels within a population have also been shown to be affected by diet, environmental exposures, pharmaceuticals, and disease status, though the reported amount of influence varies widely (Costa et al, 2005b;Deakin et al, 2003b;Ferretti et al, 2005;Gungor et al, 2011;James et al, 2000b;Precourt et al, 2009;Rainwater et al, 2009;Sirivarasai et al, 2011;Sozmen et al, 2007).…”