Biochemical evaluation of antihyperglycemic and antioxidative effects of Morinda citrifolia fruit extract studied in streptozotocin-induced diabetic rats

Abstract

The hypoglycemic and antioxidative effects of Morinda citrifolia fruit extract were evaluated in streptozotocin (STZ)-induced diabetic rats. The ethanolic extract of Morinda citrifolia fruit at a concentration of 300 mg/kg body weight/rat/ day was orally administered to STZ-induced diabetic rats for a period of 30 days. The elevated levels of blood glucose, glycosylated hemoglobin, blood urea, and serum creatinine in the diabetic rats reverted back to near normal after treatment with the noni fruit extract. Similarly significant decrease in the levels of plasma insulin and hemoglobin were elevated to near normal after treatment with fruit extract, suggesting the antihyperglycemic effect of Morinda citrifolia fruit. Determination of thiobarbituric acid reactive substance (TBARS), hydroperoxides, and both enzymatic and nonenzymatic antioxidants evidenced the antioxidative potential of the extract of noni fruit, which in turn may be responsible for its hypoglycemic potential. Alterations observed in the activities of pathophysiological enzymes such as serum aspartate transaminase (AST), serum alanine transaminase (ALT), and serum alkaline phosphatase (ALP) in the serum of control and experimental groups of rats revealed the tissue protective nature of Morinda citrifolia fruits, and the results of all the biochemical parameters analyzed were comparable with glyclazide, the standard reference drug.

Phytochemical Screening and in Vitro Antioxidant and Anti-Diabetic Potentials of Persea Americana Mill. (Lauraceae) Fruit Extract

“…The ethanolic extract which possesses the highest IC 50 for αamylase enzyme and lowest IC 50 for αglucosidase compared to acarbose and other tested extracts of Avocado fruitwas used to determine the mode of inhibition of α-amylase and αglucosidase enzymes in other to investigate its enzyme inhibition kinetics. Similar findings were observed by our previous study on Morinda citrifolia and its secondary metabolite scopoletin [52][53][54] . Nevertheless, our past research on Avocado's antihyperglycemic, antidiabetic dyslipidemic and antioxidant potentials with different studies in in vivo models well line up with the present findings 55-57 .…”

Noni Juice Improves Serum Lipid Profiles and Other Risk Markers in Cigarette Smokers

“…It is interesting to note that noni juice produced a larger decrease in plasma lipid hydroperoxide than plasma superoxide anion radicals in a previous human trial [33], indicating that noni juice may be effective in increasing the activities of glutathione peroxidase and glutathione transferase. This possibility is further supported by the observation that the activities of these enzymes were doubled in streptozotocin-induced diabetic rats fed an ethanolic extract of noni fruit for 30 days [63]. Therefore, it is possible that noni juice inhibits cigarette smoke-induced oxidative stress, and subsequent dyslipidemia, by increasing the activity of glutathione utilizing enzymes.…”

Antidiabetic and antioxidant potentials of Euphorbia hirta leaves extract studied in streptozotocin-induced experimental diabetes in rats

“…In the above context a number of other plants have also shown similar mechanism (Arulselvan et al 2006;Mahadeva Rao and Subramanian 2009).…”