Biochemical evaluation of the pprotective impact of silymarin against cyclophosphamide induced hepatotoxicity in rats

Deib, KM El; Ahmed, MM; Ahmed, NZ

doi:10.4314/ejbmb.v29i2.72440

Cited by 3 publications

(2 citation statements)

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“…In this study, we found that the administration of CTX caused damages in mice livers due to its oxidative stress, and this finding was consistent with previous reports by Selvakumar et al (2005) and El-Naggar et al (2015). The results revealed that CTX induced marked increase in relative liver weight, serum levels of ALT and AST which is considered a marker of liver damage by CTX, this finding was in agreement with El Deib et al (2011).…”

Section: Discussionsupporting

confidence: 93%

Efficacy ofRosmarinus officinalisleaves extract against cyclophosphamide-induced hepatotoxicity

El‐Naggar

Abdel-Farid

Germoush

et al. 2016

Pharmaceutical Biology

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Context Cyclophosphamide (CTX) is used to treat different cancer types, although it causes severe hepatotoxicity due to its oxidative stress effect. Rosmarinus officinalis, L. (Lamiaceae) has a therapeutic potential against hepatotoxicity due to its antioxidant activity. Objective The objective of this study is to investigate the phytochemical analysis of the methanol extract of Rosmarinus officianalis leaves (MEROL) and its efficacy against CTX-induced hepatotoxicity. Materials and methods The phytochemical analyses were assessed spectrophotometericaly. To assess the MEROL efficacy, 72 Swiss albino mice were divided into six groups. Group 1 was control, groups 2 and 3 included mice which were injected intraperitoneally (i.p.) with 100 or 200 mg/kg of MEROL at days 1, 4, 7, 10, 13 and 16; group 4 was injected (i.p.) with CTX (200 mg/kg) at day 17, groups 5 and 6 were injected (i.p.) with MEROL as groups 3 and 4 followed by 200 mg/kg CTX at day 17, respectively. At day 22, six mice from each group were sacrificed and the others were sacrificed at day 37. Results MEROL has a high content of total phenolics, saponins, total antioxidant capacity and DPPH radical scavenging activity. The median lethal dose (LD50) value of MEROL was 4.125 g/kg b.w. The inhibitory concentration 50 (IC50) value for DPPH radical scavenging was 55 μg/mL. Pretreatment with 100 mg/kg MEROL for 16 d ameliorated CTX-induced hepatotoxicity represented in lowering the levels of the aspartate aminotransferase (AST) and lipid profile and minimizing the histological damage. Conclusions Pretreatment with 100 mg/kg b.w. MEROL mitigated CTX-induced hepatotoxicity due to its antioxidant activity.

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Section: Discussionsupporting

confidence: 93%

Efficacy ofRosmarinus officinalisleaves extract against cyclophosphamide-induced hepatotoxicity

El‐Naggar

Abdel-Farid

Germoush

et al. 2016

Pharmaceutical Biology

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“…Oxygen free radical induced lipid peroxidation, which causes damage to cell membranes and consequently develops tissue injury. 38 In this study, lambda-cyhalothrin elevated renal malondialdehyde (MDA) level and reduced renal glutathione (GSH) contents as well as inhibited glutathione-s-transferase activity of the kidney tissue. The decrease in tissue GSH due to the enhancement in lipid peroxidation is considered as an antioxidant defence role of GSH.…”

Section: Discussionmentioning

confidence: 83%

Alleviating Impact of Taurine on Renal Lipid Peroxidation and Oxidative Stress in Lambda-Cyhalothrin Exposed Rat

Chakroborty¹,

Pradhan²,

Maiti³

et al. 2019

Toxicol Forensic Med Open J

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Lambda-cyhalothrin (LCT) is an isomeric form of the two biologically active diastereoisomeric pairs of cyhalothrin, containing an alpha-cyano group. Taurine or 2-aminoethane sulfonic acid is a sulfur-containing α-amino acid that is the most abundant free amino acid in most mammal tissue. Aim and Objectives The present study was focused to investigate lambda-cyhalothrin induced nephrotoxicity and renal oxidative stress as well as to evaluate the alleviating role of taurine in this condition. Methods Lambda-cyhalothrin was administered orally at two dose levels (10.83 and 15.17 mg/kg body weight) alone or in combination after pre-treatment of taurine (50 mg/kg body weight) for consecutive 14 days. Results Renal toxicity was measured by a significant decrease in renal index, reduction in kidney protein and an increase in serum protein in lambda-cyhalothrin intoxicated rats. At the same time, lambda-cyhalothrin induced a significant renal oxidative stress demonstrated by elevated renal malondialdehyde content and oxidized glutathione level accompanied by a reduction in reduced glutathione and antioxidant enzymes in rats. Lambda-cyhalothrin induced renal toxicity and oxidative stress in the rat was significantly ameliorated due to the administration of taurine as an antidote. Conclusion All of these findings of the present study strongly suggest the protective role of taurine in the pathophysiology of lambda-cyhalothrin-induced renal toxicity and oxidative stress.

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Effect of silymarin on bladder overactivity in cyclophosphamide-induced cystitis rat model

et al. 2012

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Biochemical evaluation of the pprotective impact of silymarin against cyclophosphamide induced hepatotoxicity in rats

Cited by 3 publications

References 0 publications

Efficacy ofRosmarinus officinalisleaves extract against cyclophosphamide-induced hepatotoxicity

Efficacy ofRosmarinus officinalisleaves extract against cyclophosphamide-induced hepatotoxicity

Alleviating Impact of Taurine on Renal Lipid Peroxidation and Oxidative Stress in Lambda-Cyhalothrin Exposed Rat

Effect of silymarin on bladder overactivity in cyclophosphamide-induced cystitis rat model

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