Biochemical failure and toxicity in treatment with brachytherapy and external beam radiotherapy compared with radical prostatectomy in localized prostate cancer

Galdos-Bejar, Marcelo; Belanovic-Ramirez, Ivana; Alvarado, Germán F.; Castillo, Ruben Del

doi:10.5603/rpor.a2022.0080

Cited by 1 publication

(2 citation statements)

References 52 publications

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“…Similarly, Ye et al (2022) [ 15 ] also found that combining external beam radiotherapy (EBRT) with intraluminal brachytherapy (IBT) offers an effective treatment modality for cancer with maximum local control than EBRT alone. These findings were consistent with the findings established in the study by Galdos-Bejar et al (2022) [ 14 ] by asserting that patients treated with the combination of EBRT + HDBT and RP had less biochemical failure and post-treatment toxicity than patients treated with EBRT + HDBT [ 14 ].…”

Section: Reviewsupporting

confidence: 91%

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GammaTile: Comprehensive Review of a Novel Radioactive Intraoperative Seed-Loading Device for the Treatment of Brain Tumors

Ekhator¹,

Nwankwo²,

Rak³

et al. 2022

Cureus

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GammaTile is a Food and Drug Administration (FDA)-licensed device consisting of four cesium-131 (Cs-131) radiation-emitting seeds in the collagen tile about the postage stamp size. The tiles are utilized to line the brain cavity immediately after tumor resection. GammaTile therapy is a surgically targeted radiation therapy (STaRT) that helps provide instant, dose-intense treatment after the completion of resection. The objective of this study is to explore the safety and efficacy of GammaTile surgically targeted radiation therapy for brain tumors. This study also reviews the differences between GammaTile surgically targeted radiation therapy (STaRT) and other traditional treatment options for brain tumors. The electronic database searches utilized in this study include PubMed, Google Scholar, and ScienceDirect. A total of 4,150 articles were identified based on the search strategy. Out of these articles, 900 articles were retrieved. A total of 650 articles were excluded for various reasons, thus retrieving 250 citations. We applied the exclusion and inclusion criteria to these retrieved articles by screening their full text and excluding 180 articles. Therefore, 70 citations were retrieved and included in this comprehensive literature review, as outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagram. Based on the findings of this study, GammaTile surgically targeted radiation therapy (STaRT) is safe and effective for treating brain tumors. Similarly, the findings have also shown that the efficacy of GammaTile therapy can be enhanced by combining it with other standard-of-care treatment options/external beam radiation therapy (EBRT). Also, the results show that patients diagnosed with recurrent glioblastoma (GBM) exhibit poor median overall survival because of the possibility of the tumor returning. Therefore, combining STaRT with other standard-of-care treatment options/EBRT can improve the patient's overall survival (OS). GammaTile therapy enhances access to care, guarantees 100% compliance, and eliminates patients' need to travel regularly to hospitals for radiation treatments. Its implementation requires collaboration from various specialties, such as radiation oncology, medical physics, and neurosurgery.

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Section: Reviewsupporting

confidence: 91%

“…Moreover, patients hardly require returning to hospitals as outpatients for radiation treatment. GammaTile therapy is an effective and safe radiation option that hardly requires capital investment and helps eliminate the need for repeat treatments with other related caregivers and transportation burdens [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

GammaTile: Comprehensive Review of a Novel Radioactive Intraoperative Seed-Loading Device for the Treatment of Brain Tumors

Ekhator¹,

Nwankwo²,

Rak³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

Biochemical failure and toxicity in treatment with brachytherapy and external beam radiotherapy compared with radical prostatectomy in localized prostate cancer

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited.

Cited by 1 publication

References 52 publications

GammaTile: Comprehensive Review of a Novel Radioactive Intraoperative Seed-Loading Device for the Treatment of Brain Tumors

GammaTile: Comprehensive Review of a Novel Radioactive Intraoperative Seed-Loading Device for the Treatment of Brain Tumors

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