Biochemical investigations of Albino rats orally exposed to Bonny light crude oil and leaf extract of Cnidoscolus aconitifolius

Abstract

Purpose: Bonny light crude oil has been used in folkloric medicine in treating different diseases in combination with Medicinal plants. Cnidoscolus aconitifolius has been reported to possess medicinal properties. This study is aimed at determining experimentally if the acclaimed benefits are true.
 Methodology: This study investigated the biochemical effect of Bonny light crude oil and Cnidoscolus aconitifolius leaf extract orally administered to albino rats at different concentrations. In this study, albino rats were orally exposed to different concentrations of Bonny light oil (BLCO) and Cnidoscolus aconitifolius leaf extract individually and in combination.
 Findings: The results after 21days of exposure revealed that BLCO and Cnidoscolus aconitifolius induction at concentrations of 250mg/kgb.wt and 500mg/kgb.wt could induce physiological damage within 21days. This is revealed by the results obtained from the histological analysis of the testes and the detectable heavy metal concentration in the blood samples.
 Unique Contribution to Theory, Policy and Practice: As a result, the induction of this leaf extract and BLCO at concentrations of 250mgf/kgb.wt and 500mg/kgb.wt consecutively for 21days may be injurious to health as revealed by the results from the histological analysis. Therefore, it is recommended that the use of this plant leaf extract and BLCO in folkloric medicine at concentrations similar to the ones used in this research should be avoided.

Andrographis paniculata Nees Aqueous Extract Prevents the Oxidative Stress in Rats During Acute Liver Failure by Activating the Antioxidant Enzymes

“…Further, the activity of catalase lowers the ROS by converting the H2O2 into water molecule. In the present study activity of both enzymes, SOD and catalase significantly reduced in the liver, spleen and testis of ALF rats, which is also reported by Onuoha et al (2022) as they have stated that the activity of SOD and catalase decreased in the ALF rat model. However, on treatment of APAE to the ALF rats, significantly restored the antioxidant status by lowering the liver failure induced oxidative stress in theses organs.…”

“…But in case of liver failure, it is unable to process its normal physiological process due to hepatocellular damage. Hepatic injury causes production of ROS and oxidative stress in case of liver injury (Onuoha et al, 2022), which causes decline in the antioxidant level of the liver. This oxidative stress due to hepatocellular damage in liver further have adverse effects on different organs like spleen and testis of rats and leads to multi-organ failure (MOF).…”