Biochemical Manifestation of HIV Lipodystrophy Syndrome

Ihenetu, Kenneth; Mason, Darius L.

doi:10.21106/ijma.6

Cited by 3 publications

(3 citation statements)

References 58 publications

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“…HIV-LDS includes hypertrophy in the (buffalo hump), SMF, increased fat in abdominal region, gynecomastia, and loss of fat in the mid face and extremities. [ 2 ] It is considered as a major side effect of the therapy. Evidence suggests that HIV-LDS affects up to half or even more HIV infected patients receiving ART.…”

Section: Discussionmentioning

confidence: 99%

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Use of intralesional deoxycholic acid for antiretroviral treatment associated lipohypertrophy: A qualitative open-label study of an innovative indication

Kulkarni,

Salunke,

Mandhane

et al. 2023

JCAS

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Background: With the advent of antiretroviral treatment (ART), human immunodeficiency virus/AIDS has become a chronic manageable disease. Though life expectancy has improved, it brings alongside effects of long-term medical treatment. One of the major side effects is body dysmorphism, which leads to esthetic problems. Problems of lipodystrophy (LDS), especially facial lipoatrophy as well as facial and upper back lipohypertrophy are perceived by patients as highly stigmatizing manifestations of their human immunodeficiency virus infection. It has been reported to affect mood and quality of life, as well as reduced adherence to antiretroviral medications. Patients feel discomfort while sleeping, dressing, and during day-to-day activities. Aim: The aim of this study was to test a relatively cost-effective and efficacious treatment modality for long-standing ART-associated lipohypertrophy of the submental fat and dorsocervical fat. Materials and Methods: This was a prospective open-label clinical study, in which 21 patients on regular ART with associated lipohypertrophy were enrolled in this open-label study. Deoxycholic acid (DCA) was given intralesionally once every 4–6 weeks. Patients were assessed for response, any adverse events, and patient satisfaction during every visit. Results: Intralesional DCA seems to be a promising treatment modality for long-standing ART-induced LDS with better cost-benefit in comparison with surgical interventions. Limitations: It was a small-sized sample that was studied. The lag time between starting the treatment and optimum results was long in comparison with liposuction. The result is better appreciated at the end of treatment rather than after every session implying that it has a cumulative effect. Neither pre- and post-ultrasonography nor metric documentation was done. Conclusions: Intralesional DCA seems to be a promising treatment modality for long-standing ART-induced LDS with better cost–benefit in comparison with surgical interventions.

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Section: Discussionmentioning

confidence: 99%

“…Its hallmark is dyslipidemia with changes in lipid profile, which presents before distinctive clinical features of fat redistribution become apparent. [ 4 ] Most common drugs causing it are NRTIs and PI. There have been studies showing increased cholesterol and triglyceride levels in HIV negative patients receiving ritonavir for 2 weeks.…”

Section: Discussionmentioning

confidence: 99%

Use of intralesional deoxycholic acid for antiretroviral treatment associated lipohypertrophy: A qualitative open-label study of an innovative indication

Kulkarni,

Salunke,

Mandhane

et al. 2023

JCAS

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“…Blanes et al described a case series of 3 patients receiving highly active anti-retroviral therapy (HAART) that include protease inhibitors (PI) who later developed angiolipomas [ 10 ]. Lipodystrophy, in general, is a well-documented adverse effect in patients with HIV undergoing (HAART) with or without protease inhibitors (PI) [ 11 , 12 ]. Indeed, it has been reported in over 64 % of patients undergoing treatment with such therapy, but also was reported in HIV patients not yet on anti-retroviral treatment [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Bilateral facial cutaneous angiomyolipomas: First case in the literature and a possible correlation with human immunodeficiency virus

Braganza

Aljwaid

Al-Azzawi

et al. 2020

IDCases

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Angiomyolipomas (AMLs) are benign tumors consisting of smooth muscle-like cells, adipocyte-like cells, and epithelioid cells. They are usually renal in origin, and extrarenal AMLs are rare. Cutaneous AMLs are even more rare. We present a case of 65 year old female, with no underlying genetic condition, who developed bilateral facial cutaneous AMLs. To the best of our knowledge, this is the first case in the literature. In addition, we investigate and suggest a correlation between human immunodeficiency virus and AMLs.

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Somatótipo E Imagem Corporal Em Pessoas Vivendo Com Hiv/Aids

Medeiros

Galvão

Melo

et al. 2016

Rev Bras Med Esporte

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RESUMO Introdução: A terapia antirretroviral de alta atividade (HAART) está associada ao surgimento de diversos efeitos adversos na população com HIV/Aids, dentre as quais, a lipodistrofia. Caracterizada pela reorganização anormal de gordura pelo corpo, é um dos efeitos mais relevantes, envolvendo riscos cardiometabólicos e prejuízos na imagem corporal. Objetivo: Analisar a somatotipia e a imagem corporal em pessoas vivendo com HIV/AIDS. Métodos: A amostra foi composta por cinco mulheres (47,8 ± 6,53 anos) em uso da HAART e fisicamente ativas. Foi realizada uma intervenção com o treinamento concorrente e aconselhamento dietético e avaliou-se a conformação corporal pelo somatótipo e a imagem corporal pela escala de silhuetas. Resultados: Não houve diferença na classificação do somatótipo, entretanto, os resultados apontaram diferença significativa para a análise da distância de dispersão entre somatótipos (DDS) na 1ª semana (DDS = 2,63) e 16ª semana de intervenção (DDS = 2,96), quando avaliado pelas médias; e quando avaliado individualmente, verificou-se diferença significativa tanto na DDS quanto na distância espacial entre somatótipos (DES) nos casos 1, na 8ª semana (DDS = 3,20 e DES = 1,01) e 16.a semana (DDS = 2,73); e caso 3, na 1ª semana (DDS = 9,25 e DES = 1,44) e 16ª semana (DDS = 8,06 e DES = 1,37). Quanto à imagem corporal, observou-se a aproximação da imagem atual à imagem ideal (imagem atual inicial = 6; imagem atual final = 5; e imagem ideal inicial e final = 3). Conclusão: O programa de treinamento concorrente associado à orientação nutricional produziu resultados positivos tanto no somatótipo quanto na percepção da imagem corporal das participantes, comprovando sua eficácia no controle da lipodistrofia e na satisfação da imagem corporal do grupo avaliado.

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Biochemical Manifestation of HIV Lipodystrophy Syndrome

Cited by 3 publications

References 58 publications

Use of intralesional deoxycholic acid for antiretroviral treatment associated lipohypertrophy: A qualitative open-label study of an innovative indication

Use of intralesional deoxycholic acid for antiretroviral treatment associated lipohypertrophy: A qualitative open-label study of an innovative indication

Bilateral facial cutaneous angiomyolipomas: First case in the literature and a possible correlation with human immunodeficiency virus

Somatótipo E Imagem Corporal Em Pessoas Vivendo Com Hiv/Aids

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