2014
DOI: 10.1017/s0954422414000183
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Biochemical markers for assessment of calcium economy and bone metabolism: application in clinical trials from pharmaceutical agents to nutritional products

Abstract: Nutrition plays an important role in osteoporosis prevention and treatment. Substantial progress in both laboratory analyses and clinical use of biochemical markers has modified the strategy of anti-osteoporotic drug development. The present review examines the use of biochemical markers in clinical research aimed at characterising the influence of foods or nutrients on bone metabolism. The two types of markers are: (i) specific hormonal factors related to bone; and (ii) bone turnover markers (BTM) that reflec… Show more

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Cited by 43 publications
(36 citation statements)
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References 181 publications
(231 reference statements)
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“…Although BMD is primary the therapeutic target of osteoporosis medications, measurable changes in BMD can be detected only after 12 months of treatment. BTM are clinically useful because they respond much more quickly than BMD to interventions and also predict long-term changes in BMD and fracture risk [49]. From a research perspective, BTM are also useful in understanding the effects of an intervention on bone resorption versus bone formation.…”
Section: Discussionmentioning
confidence: 99%
“…Although BMD is primary the therapeutic target of osteoporosis medications, measurable changes in BMD can be detected only after 12 months of treatment. BTM are clinically useful because they respond much more quickly than BMD to interventions and also predict long-term changes in BMD and fracture risk [49]. From a research perspective, BTM are also useful in understanding the effects of an intervention on bone resorption versus bone formation.…”
Section: Discussionmentioning
confidence: 99%
“…Since vitamin D is a well‐established nutrient in relation to bone, markers of bone formation and turnover (osteocalcin, bone specific ALP and urine N‐telopeptide crosslinks) have been considered as markers of long‐term status of vitamin D (Bonjour et al., ). Low urinary calcium excretion and an increased bone specific ALP activity have been used as biomarkers in the diagnosis of vitamin D deficiency (Section 2.2.2.1).…”
Section: Definition/categorymentioning
confidence: 99%
“…In humans, data are mixed with some, but not all [810] studies, reporting an impact of maternal vitamin D status (25-hydroxyvitamin D [25(OH)D]) on fetal bone development [1115] and maternal bone turnover [16,17]. These differences across studies may be secondary to diverse maternal intakes of calcium and phosphorus from food and supplements, which like vitamin D, play essential roles in bone biology and thus are important confounders [1820]. …”
Section: Introductionmentioning
confidence: 99%