Biochemical markers in suicidal patientsInvestigations with cerebrospinal fluid amine metabolites and neuroendocrine tests

Bánki, Csaba M.; Arató, M.; Papp, Zsuzsa; Kurcz, M

doi:10.1016/s0165-0327(84)80012-9

Cited by 178 publications

(37 citation statements)

References 26 publications

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“…This was rather unexpected, since previous studies reported that total cortisol levels in CSF are less than 10% of those in plasma (34,35,36). The CSF-cortisol levels reported in literature are thus close to free plasma cortisol levels (34,(36)(37)(38).…”

Section: Years) Andmentioning

confidence: 69%

Increased Cortisol Levels in Aging and Alzheimer's Disease in Postmortem Cerebrospinal Fluid

Swaab

Raadsheer

Endert

et al. 1994

J Neuroendocrinology

134

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The hypothalamo-pituitary-adrenal (HPA) axis is activated during aging and even more so in dementia. Increased levels of corticosteroids may be neurotoxic. Therefore we have investigated cortisol levels in cerebrospinal fluid (CSF) of Alzheimer patients and controls. Ventricular postmortem CSF was collected from clinically and neuropathologically well-defined Alzheimer patients (n = 26) and control subjects (n = 21). In the group of Alzheimer patients the mean CSF total cortisol level was 83% higher than that in the controls. In presenile Alzheimer patients (< 65 years of age; n = 13) the CSF-cortisol level was 5 times higher than that of presenile controls (n = 7). In contrast, senile Alzheimer patients (n = 13) and controls of over 65 years of age (n = 14) did not show a significant difference in CSF-cortisol levels. The presence or absence of a difference in the cortisol-CSF levels in, respectively, presenile or senile Alzheimer patients as compared to controls was due to the 3.5-fold rise of CSF-cortisol in control subjects over 65 years of age as compared with controls under 65 years of age. The CSF-cortisol levels in presenile and senile Alzheimer patients were similar. No significant correlation was observed in the Alzheimer patients between age of onset of the dementia and CSF cortisol levels or duration of Alzheimer's disease and CSF cortisol levels. The finding that in senile Alzheimer patients cortisol levels were similar to those of unaffected age-matched controls does not seem to support the cortisol neurotoxicity hypothesis.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Years) Andmentioning

confidence: 69%

Increased Cortisol Levels in Aging and Alzheimer's Disease in Postmortem Cerebrospinal Fluid

Swaab

Raadsheer

Endert

et al. 1994

J Neuroendocrinology

134

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“…Low brain serotonin has been implicated in depression [Asberg et al, 1984;Banki et al, 1984;Coppen, 1967;Coppern et al, 1972Coppern et al, , 1978 Curzon, 1969;Shopsin et al, 1976;van Praag, 1982, 19861, violent suicide attempts [Lidberg et al, 1985;Traskman et al, 19811, antisocial and borderline personality disorder [Brown et al, 1979, 19821, attention deficit disorder [Coleman, 1971;Greenberg and Coleman, 1976;Saul and Ashby, 1986;Wender, 19691, alcoholism [Ballenger et al, 1979;Banki, 1981;Banki et al, 1984;Branchey et al, 1984;Myers and Melchior, 19781, arson [Roy et al, 1986;Virkkunen et al, 19871, bulimia [Kaye et al, 19841, sleep disorders [Jacobs and Trulson, 1979;Jouvet, 1969;Trulson and Jacobs, 19791, sexual disinhibition [Everett, 1975;Gessa et al, 1970;Gessa and Tagiamonte, 19751, premenstrual tension [Rapkin et al, 19871, panic attacks [Gloger et al, 19811, phobias [Evans et al, 19801, and migraine headaches [Barabas et al, 1984;Curran et al, 19651. Low brain serotonin appears to play a particularly important role in impulsive and aggressive behaviors [Brown et al, ,1982Linnoila et al, 1983;Soubrie, 1986;Valzelli, 1984, 19851. Abnormalities of serotonin have also been described in obsessive-compulsive [Flament et al, 1987;Thoren et al, 1980;Zohar and Insel, 19871, manic-depressive [WirzJustice and Puhringer, 19781, schizophrenic [Benassi et al, 1961;<...>…”

Section: Serotonin and "Ryptophanmentioning

confidence: 99%

Blood serotonin and tryptophan in Tourette syndrome

Comings

1990

Am. J. Med. Genet.

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Blood serotonin and tryptophan levels were studied in 1,440 individuals. These included patients with Tourette syndrome (TS), attention deficit hyperactivity disorder (ADHA), or ADHD with a family history of TS (ADHD 2 degrees TS); relatives (parents, sibs) of these patients; other patients with TS-like disorders; and controls. There were significant decreases in the serotonin/platelet ratio (P = 0.0001) and in tryptophan (P less than 0.0001) in unmedicated patients with TS. Parents of TS patients showed a comparable, significant decrease in serotonin/platelet ratio (P less than 0.0001) and in tryptophan (P less than 0.0001), and there was no difference between parents with and without symptoms. This suggested that these were trait markers for the Gts gene and agrees with the proposal that TS patients are homozygous for Gts gene and that both parents are Gts gene carriers. Although there was no decrease in the serotonin/platelet ratio in ADHD patients, tryptophan levels were significantly decreased and there was a significant decrease in both the serotonin/platelet ratio and in tryptophan in the parents of patients with ADHD including those without a family history of TS. This is consistent with a close link between TS and ADHD. The basic defect may be a dysregulation of serotonin metabolism. The low blood serotonin and tryptophan levels in TS are consistent with the wide range of behavioral disorders seen in TS and suggest tryptophan oxygenase as a possible candidate gene.

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“…Initial evidence for the involvement of 5-Ht in suicide stemmed from findings of low CSF 5-hydroxyindoleacetic acid (5-HIAA) levels in depressed suicide attempters and in the brain stems of completed suicides (Asberg 1997;Asberg et al 1976;Banki et al 1984;Carlsson et al 1980;Mann and Malone 1997;Placidi et al 2001;Roy et al 1986;träskman et al 1981). Although the link between low CSF 5-HIAA and suicidality has been debated (Roggenbach et al 2002), significantly lower levels of CSF 5-HIAA have also been reported in a meta-analysis of CSF metabolite studies in subjects who made prior suicide attempts and those who subsequently committed suicide (Lester 1995).…”

Section: Serotonergic Function In Suicidementioning

confidence: 99%

Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy

Boulougouris

Malogiannis

Lockwood³

et al. 2013

Exp Brain Res

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Biochemical markers in suicidal patientsInvestigations with cerebrospinal fluid amine metabolites and neuroendocrine tests

Cited by 178 publications

References 26 publications

Increased Cortisol Levels in Aging and Alzheimer's Disease in Postmortem Cerebrospinal Fluid

Increased Cortisol Levels in Aging and Alzheimer's Disease in Postmortem Cerebrospinal Fluid

Blood serotonin and tryptophan in Tourette syndrome

Serotonergic modulation of suicidal behaviour: integrating preclinical data with clinical practice and psychotherapy

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