Biochemical markers in the diagnosis of chondral defects following anterior cruciate ligament insufficiency

Streich, N.; Zimmermann, David; Schmitt, Holger; Bode, Gerrit

doi:10.1007/s00264-010-1191-5

Cited by 16 publications

(11 citation statements)

References 20 publications

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“…4 Streich NA 12 reported increase in CTX I level is related with increase in local production of inflammatory cytokines resulting in uncoupling of bone turnover and finally cartilage degradation. 12 Increased levels of urinary CTX I indicates increased bone resorption in cases with progressive OA but not in non-progressive OA has been reported earlier. 7,8,13,14 Garnero P et al 15 reported that high baseline urinary CTX I independently predicts an increased risk of OA.…”

Section: Discussionmentioning

confidence: 68%

Role of Urinary CTX I in Early Diagnosis of Osteoarthritis

Singh¹

2015

MOJOR

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Introduction: The early diagnosis of osteoarthritis is required to do possible intervention in early stage of disease because it is one of the leading causes of disability in advance stage. For this reason various biomarker have been studied having merits and demerits of each. We chose urinary CTX-1 as biomarker to assess its role in osteoarthritis in knee joint. Methodology: the study included 100 patients of primary osteoarthritis of knee joint and 50 controls. They were subjected to WOMAC scoring and K-L grading and estimation of urinary CTX-I. Statistical analysis was done using SPSS software version 20.0. Results: Mean CTX-I levels of Control Group were 12.28±5.3ng/dl and in Case Group was 37.13±23.8 ng/dl and this difference was highly significant (p<0.001). Strong correlation was found between K-L grading and urinary CTX-I on Spearman's correlation coefficient. These associations were found to be highly significant (p<0.001). Receiver operator curve (ROC) analysis was done for prediction of cutoff values between Control group and Case group found >14.4ng/ml as cutoff point between Control group and Case group. Conclusion: Since CTX-I is biomarker of bone resorption and bone resorption is found more in case of progressive osteoarthritis of knee joint hence, we believe that CTX I levels can help in early identification of progressive OA cases.

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Section: Discussionmentioning

confidence: 68%

Role of Urinary CTX I in Early Diagnosis of Osteoarthritis

Singh¹

2015

MOJOR

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“…Some data show that ACLinjured knees are at risk for degenerative changes at longterm follow-up whether the ligament is reconstructed or not [34,35]. Biomechanical markers of turnover of bone and cartilage have been investigated in blood and urine to identify focal cartilage lesions from an early stage of osteoarthritis after injury of the human ACL [36]. Degeneration seems to be caused by intra-articular processes induced at the time of ACL injury, combined with long-term dynamic joint loading changes [37].…”

Section: Discussionmentioning

confidence: 98%

Anterior Cruciate Ligament deficiency leads to early instability of scaffold for cartilage regeneration: a controlled laboratory ex-vivo study

Efe

Füglein

Getgood

et al. 2011

International Orthopaedics (SICOT)

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“…Higher concentrations of pro-inflammatory biomarkers within synovial fluid were also found in patients with acute ACL injury who had associated cortical fractures identified on MR imaging 169 . At longer follow-up periods in patients with ACL tear, more severe cartilage damage on MR imaging was associated with increased serum biomarkers of bone and cartilage turnover 20 years after injury 170 and with increased serum concentrations of the small nucleolar RNA U38 1 year after injury 171 . Higher collagen cleavageto-synthesis ratio was also noted in patients with abnormal joint space width on knee radiographs 4 years after ACL injury 172 .…”

Section: Association Between Imaging Findings and Wet Biomarkers Follmentioning

confidence: 94%

Imaging following acute knee trauma

Kijowski

Roemer

Englund

et al. 2014

Osteoarthritis and Cartilage

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Joint injury has been recognized as a potent risk factor for the onset of osteoarthritis. The vast majority of studies using imaging technology for longitudinal assessment of patients following joint injury have focused on the injured knee joint, specifically in patients with anterior cruciate ligament injury and meniscus tears where a high risk for rapid onset of post-traumatic osteoarthritis is well known. Although there are many imaging modalities under constant development, magnetic resonance (MR) imaging is the most important instrument for longitudinal monitoring after joint injury. MR imaging is sensitive for detecting early cartilage degeneration and can evaluate other joint structures including the menisci, bone marrow, tendons, and ligaments which can be sources of pain following acute injury. In this review, focusing on imaging following acute knee trauma, several studies were identified with promising short-term results of osseous and soft tissue changes after joint injury. However, studies connecting these promising short-term results to the development of osteoarthritis were limited which is likely due to the long follow-up periods needed to document the radiographic and clinical onset of the disease. Thus, it is recommended that additional high quality longitudinal studies with extended follow-up periods be performed to further investigate the long-term consequences of the early osseous and soft tissue changes identified on MR imaging after acute knee trauma.

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Biochemical markers in the diagnosis of chondral defects following anterior cruciate ligament insufficiency

Abstract: The results suggest that uCTX-I, uCTX-II and sCOMP could identify patients with focal cartilage lesions from an early stage of osteoarthritis of the knee.

Cited by 16 publications

References 20 publications

Role of Urinary CTX I in Early Diagnosis of Osteoarthritis

Role of Urinary CTX I in Early Diagnosis of Osteoarthritis

Anterior Cruciate Ligament deficiency leads to early instability of scaffold for cartilage regeneration: a controlled laboratory ex-vivo study

Imaging following acute knee trauma

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