Biochemical markers of apoptosis in different parts of the brain during learning

Шерстнев, В. В.; Yurasov, V. V.; Сторожева, З. И.; Gruden, M. A.; Yakovleva, N E

doi:10.1007/s11055-006-0107-8

Cited by 5 publications

(7 citation statements)

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“…For example, protein сaspase-3 which is regarded as a key link in caspase dependent apoptosis [33] is known to be involved in molecular mechanisms of learning and memory [34,35] based on the principles of brain regional specificity and heterochrony [36]. Addressing this concern, a recent study reported that caspase-3 participates not only in processes of programmed cell death but also neuronal plasticity [37].…”

Section: Discussionmentioning

confidence: 99%

Distinct functional brain regional integration of Casp3, Ascl1 and S100a6 gene expression in spatial memory

Gruden

Сторожева

Sewell

et al. 2013

Behavioural Brain Research

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Evaluating the brain structural expression of defined genes involved in basic biological processes of neurogenesis, apoptosis or neural plasticity may facilitate the understanding of genetic mechanisms underlying spatial memory. The aim of the present study was to compare Ascl1, Casp3 and S100a6 gene expression in the hippocampus, prefrontal cortex and cerebellum of adult rats in water maze spatial memory performance. After four days training, the mean platform time (<10s) was evidence of stable long-term spatial memory formation. Real time PCR analysis revealed a positive inter-structural correlation for S100a6/Casp gene expression between the prefrontal cortex and the cerebellum but a negative correlation for S100a6/Ascl1 transcribed genes between the prefrontal cortex and hippocampus during swimming in the active controls. However, during spatial memory performance there was only one inter-structural correlation between the prefrontal cortex and cerebellum with respect to Casp3 expression, though there were intra-structural correlations between Casp3/Ascl1 transcriptions within the prefrontal cortex and hippocampus as well as between Ascl1/S100a6 in the cerebellum. In active learners versus naive controls, the transcrption of all genes was augmented in the prefrontal cortex but Casp3 and Ascl1 were also elevated in hippocampus whilst only S100a6 increased in the cerebellum. The findings endorsed the role of the hippocampus in memory acquisition in addition to an integrative relationship with the prefrontal cortex and cerebellum. This structural and molecular configuration is important for creation of novel neural circuitry for consolidation and reconsolidation of memory trace with an involvement of coupled processes of neurogenesis, apoptosis or neural plasticity.

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Section: Discussionmentioning

confidence: 99%

Distinct functional brain regional integration of Casp3, Ascl1 and S100a6 gene expression in spatial memory

Gruden

Сторожева

Sewell

et al. 2013

Behavioural Brain Research

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“…As caspase 3 has been linked to physiological plasticity downstream of NMDA receptor stimulation in the CNS (Sherstnev et al. , 2006; Li et al.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Basal caspase 3 activity was detected in both cortex and cerebellum from the brains of adult WT mice. This caspase 3 activity may conceivably relate to physiological processes, including synaptic plasticity and learning (Sherstnev et al, 2006;Li et al, 2010). Alternatively, there is thought to be a low level of ageing-associated apoptosis occurring in the adult brain, as other apoptotic mediators are found in association with caspase 3 activity (Higami & Shimokawa, 2000;Pollack et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…As caspase 3 has been linked to physiological plasticity downstream of NMDA receptor stimulation in the CNS (Sherstnev et al, 2006;Li et al, 2010), as well as the very early stages of Alzheimer's disease (D'Amelio et al, 2010), we also investigated caspase 3 activity in adult brain tissue. A substantial level of caspase 3 activity was detected in both cortex and cerebellum from the brains of WT mice.…”

Section: Effect Of Deletion Of the Rhob Gene On Constitutive Caspase mentioning

confidence: 99%

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Altered apoptotic responses in neurons lacking RhoB GTPase

Barberan

McNair

Iqbal

et al. 2011

Eur J of Neuroscience

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Caspase 3 activation has been linked to the acute neurotoxic effects of central nervous system damage, as in traumatic brain injury or cerebral ischaemia, and also to the early events leading to long-term neurodegeneration, as in Alzheimer’s disease. However, the precise mechanisms activating caspase 3 in neuronal injury are unclear. RhoB is a member of the Rho GTPase family that is dramatically induced by cerebral ischaemia or neurotrauma, both in preclinical models and clinically. In the current study, we tested the hypothesis that RhoB might directly modulate caspase 3 activity and apoptotic or necrotic responses in neurons. Over-expression of RhoB in the NG108-15 neuronal cell line or in cultured corticohippocampal neurons elevated caspase 3 activity without inducing overt toxicity. Cultured corticohippocampal neurons from RhoB knockout mice did not show any differences in sensitivity to a necrotic stimulus – acute calcium ionophore exposure – compared with neurons from wild-type mice. However, corticohippocampal neurons lacking RhoB exhibited a reduction in the degree of DNA fragmentation and caspase 3 activation induced by the apoptotic agent staurosporine, in parallel with increased neuronal survival. Staurosporine induction of caspase 9 activity was also suppressed. RhoB knockout mice showed reduced basal levels of caspase 3 activity in the adult brain. These data directly implicate neuronal RhoB in caspase 3 activation and the initial stages of programmed cell death, and suggest that RhoB may represent an attractive target for therapeutic intervention in conditions involving elevated caspase 3 activity in the central nervous system.

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We Care, Therefore We Are: Anesthesia-related Morbidity and Mortality

Cottrell¹

2008

Anesthesiology

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Biochemical markers of apoptosis in different parts of the brain during learning

Cited by 5 publications

References 5 publications

Distinct functional brain regional integration of Casp3, Ascl1 and S100a6 gene expression in spatial memory

Distinct functional brain regional integration of Casp3, Ascl1 and S100a6 gene expression in spatial memory

Altered apoptotic responses in neurons lacking RhoB GTPase

We Care, Therefore We Are: Anesthesia-related Morbidity and Mortality

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