Biochemical Markers of Bone Turnover in Chronic Obstructive Pulmonary Disease (COPD)

Vázquez, Emma; Punter, Rosa Mar Gómez; Moreno, Rosa Girón; Sánchez, Sílvia; Riolobos, Cristina López; Bermúdez, Julio Ancochea

doi:10.1378/chest.1816742

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“…COPD is associated with lower bone mineral density and has a high prevalence of osteoporosis. 30 – 32 This may be because tobacco smoking, systemic inflammation, vitamin D deficiency, and the use of oral or inhaled corticosteroids are common risk factors of both COPD and osteoporosis. 33 …”

Section: Discussionmentioning

confidence: 99%

Czech multicenter research database of severe COPD

Novotná¹,

Koblížek²,

Zatloukal³

et al. 2014

COPD

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PurposeChronic obstructive pulmonary disease (COPD) has been recognized as a heterogeneous, multiple organ system-affecting disorder. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) places emphasis on symptom and exacerbation management. The aim of this study is examine the course of COPD and its impact on morbidity and all-cause mortality of patients, with respect to individual phenotypes and GOLD categories. This study will also evaluate COPD real-life patient care in the Czech Republic.Patients and methodsThe Czech Multicentre Research Database of COPD is projected to last for 5 years, with the aim of enrolling 1,000 patients. This is a multicenter, observational, and prospective study of patients with severe COPD (post-bronchodilator forced expiratory volume in 1 second ≤60%). Every consecutive patient, who fulfils the inclusion criteria, is asked to participate in the study. Patient recruitment is done on the basis of signed informed consent. The study was approved by the Multicentre Ethical Committee in Brno, Czech Republic.ResultsThe objective of this paper was to outline the methodology of this study.ConclusionThe establishment of the database is a useful step in improving care for COPD subjects. Additionally, it will serve as a source of data elucidating the natural course of COPD, comorbidities, and overall impact on the patients. Moreover, it will provide information on the diverse course of the COPD syndrome in the Czech Republic.

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Section: Discussionmentioning

confidence: 99%