Biochemical markers of liver and kidney function are influenced by thyroid function-a case-controlled follow up study in Indian hypothyroid subjects

Arora, Sarika; Chawla, Ranjna; Tayal, Devika; Gupta, Vinod Kumar; Sohi, Jagdeep S; Mallika, V.

doi:10.1007/s12291-009-0067-1

Cited by 40 publications

(32 citation statements)

References 18 publications

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“…Unfortunately, the various symptoms caused by the resultant hypothyroidism may cause patients to be reluctant to undergo the following RIT. These biochemical changes in uncomplicated hypothyroidism are usually mild and reversible with adequate thyroid hormone therapy [13,14]. This alternative RIT method is based on rhTSH administration and allows the patient to maintain a euthyroid level of fT4 during RIT.…”

Section: Discussionmentioning

confidence: 99%

“…Serum creatinine (Cr) levels increase in the uncomplicated hypothyroid state before RIT in patients with normal renal function because of a decrease in renal blood flow and glomerular filtration [7,11]. Recent studies have also shown that liver function also undergoes a reversible change before RIT and recovers to the euthyroid state after thyroid hormone replacement [13][14][15]. Recent studies have also shown that liver function also undergoes a reversible change before RIT and recovers to the euthyroid state after thyroid hormone replacement [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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The effect of recombinant human thyroid stimulating hormone on sustaining liver and renal function in thyroid cancer patients during radioactive iodine therapy

Lee

et al. 2014

Nuclear Medicine Communications

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of recombinant human thyroid stimulating hormone on sustaining liver and renal function in thyroid cancer patients during radioactive iodine therapy

Lee

et al. 2014

Nuclear Medicine Communications

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“…Thyroid is an important endocrine gland and produces two main hormones thyroxine (T4) and tri-iodo thyronine (T3) [7]–[9]. Both of these hormones are under control of thyroid stimulating hormone (TSH) released by anterior pituitary gland and in turn it is controlled by thyrotrophin releasing hormone (TRH) of hypothalamus.…”

Section: Introductionmentioning

confidence: 99%

Expression of Osteopontin in Patients with Thyroid Dysfunction

et al. 2013

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Thyroid dysfunctions are common endocrine problems. They are often misdiagnosed, misunderstood, and frequently overlooked. These disorders affect almost every aspect of health. Most of them remain undetected because the clinical assessment alone lacks both sensitivity and specificity. As it is not sufficient enough we require the biochemical tests to confirm the diagnosis. As a consequence there is still great interest in new biomarkers that complement existing diagnostic tools. Osteopontin, a glycoprotein that can be detected in plasma, was found to be upregulated in several patients with hyperthyroidism and downregulated in hypothyroid patients so it may represent a new biomarker. 100 patients with thyroid dysfunctions (50 hyperthyroid, 50 hypothyroid) and 100 normal subjects were included in the study. Osteopontin and other clinical parameters for diagnosis of thyroid disorders were measured. Osteopontin is positively correlated with T3 and T4 (r = 0.62 and r = 0.75 respectively) while it is negatively correlated with thyroid stimulating hormone (r = −0.52) showing a significant correlation (p-value <0.001). Our findings suggest that osteopontin might be useful as a novel prognostic biomarker in patients with impaired thyroid function.

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“…Hypothyroidism has been associated in a few case reports with cholestatic jaundice attributed to reduced bilirubin and bile excretion [13]. In experimental hypothyroidism, the activity of bilirubin UDP glucuronyltransferase is decreased, resulting in a reduction in bilirubin excretion [14]. Thyroid hormones (THs) also oppose the action of insulin and stimulate hepatic gluconeogenesis and glycogenolysis; they up-regulate the expression of genes such as glucose transporter type-4 (GLUT--4) and phosphoglycerate kinase, involved in glucose transport and glycolysis, respectively, thus acting synergistically with insulin facilitating glucose disposal and utilization in peripheral tissues [15].…”

Section: Introductionmentioning

confidence: 99%

The impact of high fat diets on physiological changes in euthyroid and thyroid altered rats

et al. 2013

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The association of adverse health with high fat intake has long been recognized. However, the lack of research focusing on the interrelationship of thyroid and liver function, and the pathogenesis of a high fat diet leaves these topics poorly understood. The objective of this study was to evaluate and compare the physiological changes in euthyroid and thyroid altered animal model fed saturated and unsaturated high fat diets. To achieve this objective adult male Sprague Dawley rats (n = 100) were fed one of five diets; a control or one of four test diets containing 25% saturated or unsaturated, and 37% saturated or unsaturated fats for a period of eight weeks. Each experimental group consisted of ten euthyroid and ten thyroid altered animals. An altered thyroid state was chemically induced with the addition of 0.05% propylthiouracil (PTU) in the drinking water. Euthyroid animals fed high fat diets increased in body weights and body lengths, compared to thyroid altered animals (P < 0.05). Alanine aminotransferase (ALT) and asparte aminotransferase (AST) levels increased across all experimental groups. HbA1C values and urinary glucose values were within normal range for all animals. Liver morphology showed increased hepatic stellate (ito) and vacuole cells in thyroid altered animals. These findings suggest that altered thyroid status negatively impacts growth and weight gain, and simultaneously affected lipid metabolism, resulting in abnormal liver morphology.

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Biochemical markers of liver and kidney function are influenced by thyroid function-a case-controlled follow up study in Indian hypothyroid subjects

Abstract: ABSTRACT

Cited by 40 publications

References 18 publications

The effect of recombinant human thyroid stimulating hormone on sustaining liver and renal function in thyroid cancer patients during radioactive iodine therapy

The effect of recombinant human thyroid stimulating hormone on sustaining liver and renal function in thyroid cancer patients during radioactive iodine therapy

Expression of Osteopontin in Patients with Thyroid Dysfunction

The impact of high fat diets on physiological changes in euthyroid and thyroid altered rats

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