Biochemical markers of myocardial injury

Kemp, Michael; Donovan, Jackie; Higham, Helen; Hooper, James

doi:10.1093/bja/aeh148

Cited by 203 publications

(160 citation statements)

References 124 publications

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“…However, when we performed site-specific analysis with cancer-specific death as the outcome of interest, this association was only shown in those diagnosed with prostate, pulmonary, colorectal, gastro-oesophageal, gynaecological or haematological cancer. Considering the link of LDH with other chronic diseases that may contribute to death (Kemp et al, 2004;Kato et al, 2006), it is therefore important to consider causespecific death to gain further insight into the prognostic relevance of LDH. We observed a borderline inverse trend between LDH and head and neck cancer death, although our analysis was limited by the number of events.…”

Section: Discussionmentioning

confidence: 99%

“…Lactate dehydrogenase measured within 12 months before the diagnosis of cancer was shown to be strongly associated with overall and cancer-specific death, further indicating the relevance between LDH and tumour growth or severity. The positive association between LDH measured within 30 to 36 months before diagnosis and risk of overall as well as breast cancer death further signifies the importance of assessing cancer-specific death, especially because higher LDH is also linked to cardiovascular disease and mortality (Savory and Pryce, 1980;Kemp et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Information on race/ethnicity was not available; however, the AMORIS cohort was similar to the general working population of Stockholm (Wulaningsih et al, 2013b) that comprised B80% Swedish-born individuals in 2000 (Statistics Sweden, 2015). Serum LDH increases because of other conditions such as myocardial infarction, inflammation and tissue injury (Drent et al, 1996;Kemp et al, 2004;Kato et al, 2006), and therefore is not a specific marker of tumour. Higher LDH at baseline may otherwise indicate inflammation or other disorders involved in pathways leading to cancer development.…”

Section: Discussionmentioning

confidence: 99%

“…It is expressed in all tissues and its A and B subunits, coded by two different genes LDH-A and LDH-B, combine to construct five isoenzymes (LDH1 to LDH5) with selective distribution among tissues and in serum (Maekawa, 1988). In addition, LDH is known as a marker for tissue injury, inflammation, haemolysis and myocardial infarction (Drent et al, 1996;Kemp et al, 2004;Kato et al, 2006). Elevated LDH levels are seen in cancer patients, and its prognostic value has been shown in several malignancies such as germ cell tumours, lymphoma, melanoma and renal cell carcinoma (Balch et al, 2004;Barlow et al, 2010;Armstrong et al, 2012;Nagle et al, 2013).…”

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confidence: 99%

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1009 Serum lactate dehydrogenase and survival following cancer diagnosis

Wulaningsih¹,

Holmberg²,

Garmo³

et al. 2015

European Journal of Cancer

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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1009 Serum lactate dehydrogenase and survival following cancer diagnosis

Wulaningsih¹,

Holmberg²,

Garmo³

et al. 2015

European Journal of Cancer

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“…In the current work, the influence of various extraction processes for creation macro imprints have been investigated and their performances have been compared. Troponin T (TnT) is a specific biomarker for myocardial tissue that it is used as an inexpensive and fast cardiac biomarker test for early cardiac disease diagnosis (Kemp, 2004). A wide variety of immunoassay configurations have been developed for its determination (Klein et al, 1998;Asano et al, 2012;Dengler et al, 1998;Katus et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Electrochemical evaluation of troponin T imprinted polymer receptor

Karimian

Turner

Tiwari

2014

Biosensors and Bioelectronics

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The selective detection and quantification of macromolecular targets is a fundamental biological mechanism in nature. Molecularly imprinted polymers (MIPs) have been identified as one of the most promising synthetic alternatives to bioreceptors. However, expanding this methodology towards selective recognition of bulky templates such as proteins appears to be extremely challenging due to problems associated with removal of the template from the polymeric network. In this study, polymer imprinted with troponin T (TnT) was assessed using

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Elevated α‐hydroxybutyrate dehydrogenase as an independent prognostic factor for mortality in hospitalized patients with COVID‐19

Liu

et al. 2020

ESC Heart Failure

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Aims Many studies have explored the clinical characteristics of patients with coronavirus disease (COVID-19), especially patients with cardiovascular disease. However, associated mechanisms and markers remain to be further investigated. This study aimed to investigate the effect of α-hydroxybutyrate dehydrogenase (α-HBDH) levels on disease progression and prognosis of patients with COVID-19. Methods and results One thousand seven hundred and fifty-one patients from the Leishenshan hospital in Wuhan were divided into elevated and normal groups by α-HBDH level, and the clinical information between the two groups was compared retrospectively. The main outcome evaluation criteria included in-hospital death and disease severity. Univariate and multivariate regression analyses, survival curves, logistic regression, and receiver operating characteristic curve models were performed to explore the relationship between elevated α-HBDH and the two outcomes. Besides, curve fitting analyses were conducted to analyse the relationship between computed tomography score and survival. Among 1751 patients with confirmed COVID-19, 15 patients (0.87%) died. The mean (SD) age of patients was 58 years in normal α-HBDH group and 66 years in elevated α-HBDH group (P < 0.001). The mortality during hospitalization was 0.26% (4 of 1559) for patients with normal α-HBDH levels and 5.73% (11 of 192) for those with elevated α-HBDH levels (P < 0.001). Multivariate Cox analysis confirmed an association between elevated α-HBDH levels and higher risk of in-hospital mortality [hazard ratio: 4.411, 95% confidence interval (95% CI), 1.127-17.260; P = 0.033]. Multivariate logistic regression for disease severity and α-HBDH levels showed significant difference between both groups (odds ratio = 3.759; 95% CI, 1.895-7.455; P < 0.001). Kaplan-Meier curves also illustrated the survival difference between normal and elevated α-HBDH patients (P < 0.001). Conclusions Our study found that serum α-HBDH is an independent risk factor for in-hospital mortality and disease severity among COVID-19 patients. α-HBDH assessment may aid clinicians in identifying high-risk individuals among COVID-19 patients.

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Biochemical markers of myocardial injury

Cited by 203 publications

References 124 publications

1009 Serum lactate dehydrogenase and survival following cancer diagnosis

1009 Serum lactate dehydrogenase and survival following cancer diagnosis

Electrochemical evaluation of troponin T imprinted polymer receptor

Elevated α‐hydroxybutyrate dehydrogenase as an independent prognostic factor for mortality in hospitalized patients with COVID‐19

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