Biochemical markers of neonatal myocardial dysfunction

Almeida, Cristina M.; Carrapato, Manuel Rui Garcia; Pinto, FJ; Pinto, Mariana Mendes; Sofia, Ferreira; Schmitt, Denise; Luis, Marinho

doi:10.3109/14767058.2010.511334

Cited by 20 publications

(16 citation statements)

References 29 publications

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“…The results for CPK-MB activity were recorded as: sensitivity (71.7%), specificity (56.6%), PPV (62.29%), NPV (66.7%), PLR (1.65), and NLR (0.5). They observed a significant elevation in CPK and CPK-MB serum activity in EP and concluded that transvaginal ultrasound (TVS) as better diagnostic tool for EP (64)(65)(66). CORD BLOOD CREATINE KINASE LEVELS Total CK and CK isoenzyme activity in serum during pregnancy, labor and after delivery as well as in cord blood was estimated in a study by Chemnitz and others.…”

Section: Creatine Kinase In Pregnancymentioning

confidence: 99%

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Total Creatine Kinase and Its Isoenzymes in Cord Blood of Full Term Newborns

Khan¹,

Rathore²

2017

EJMR

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Creatine kinase (CK) is a key enzyme of energy metabolism, especially in muscle tissue. CK has two polypeptide chains of M and B, and three isomers, CK-BB, CK-MB and CK-MM. In some conditions like acute myocardial infarction and Neuromuscular disorders, increased CK activity is used as a part of diagnosis. CK can also be elevated in absence of neuromuscular diseases or cardiac injury, such as strenuous exercise, intramuscular injections etc.Several reports indicate elevated activity of serum CK in the maternal blood during child birth.

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Section: Creatine Kinase In Pregnancymentioning

confidence: 99%

“…The rise in cTnI may be explained by a degree of myocardial involvement. The initial rise and subsequent fall of NT-proBNP represents the physiological ventricular overload of transient birth adaptation (64). Nakajima and Masaoka determined whether the tocolytic therapy affects CK activity in the umbilical blood.…”

Section: E J M Rmentioning

confidence: 99%

Total Creatine Kinase and Its Isoenzymes in Cord Blood of Full Term Newborns

Khan¹,

Rathore²

2017

EJMR

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Section: Cardiac Pathologymentioning

confidence: 99%

“…Almeida et al (2011) detected low concentrations of cTnI in human cord blood. However, in otherwise normal neonates' maximal increases in cTnI concentrations peaked between 48 and 72 hr after birth and declined by 50% by the 10th day of life (Almeida et al 2011). The finding that elevated serum troponin concentrations were more common in normal neonatal blood than in umbilical cord blood is consistent with other studies that found maximal FIGURE 3.-Age comparison of serum cardiac troponin I concentrations in patas monkeys at birth, 2, 6 months, and 1 year of age.…”

Section: Cardiac Pathologymentioning

confidence: 99%

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The Influence of Age on Serum Concentrations of Cardiac Troponin I

et al. 2013

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Cardiac troponins serve as serum biomarkers of myocardial injury. The current study examined the influence of age on serum concentrations of cardiac troponin I (cTnI). An ultrasensitive immunoassay was used to monitor cTnI concentrations in Sprague-Dawley (SD) rats and Erythrocebus patas monkeys of different ages. The mean cTnI concentrations were highest in 10-day-old rats compared to 25-, 40-, and 80-day-old SD rats. Cardiomyocyte remodeling was apparent in hearts from 10-day-old SD rats as evident by hypercellularity, irregularly shaped nuclei, and moderate numbers of myocytes undergoing mitosis and apoptosis. The mean concentration of cTnI in 5 newborn monkeys was considerably higher than that of three 1-year-old monkeys. Evidence of cardiomyocyte remodeling was also observed in these newborn hearts (loss of myofibrils and cytoplasmic vacuolation). Commercial animal serum samples were also analyzed. The concentrations of cTnI detected in fetal equine and porcine serum were considerably higher than that found in adult equine and porcine serum samples Likewise, fetal bovine serum had higher cTnI concentrations (>2,400 pg/ml) than did adult caprine and laprine samples (2.5-2.7 pg/ml). The present study found age-related differences in cTnI concentrations, with higher levels occurring at younger ages. This effect was consistent across several animal species.

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N-Terminal Pro-Brain Natriuretic Peptide As a Useful Predictor of Early Surgery in Neonates With Congenital Heart Diseases: A Prospective Observational Study

Makimura

Koga

2013

Pediatr Cardiol

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Pediatric studies have found a correlation between the clinical heart failure score and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels. However, the clinical usefulness of this marker remains unclear in neonates. At hospitals without pediatric cardiologists, neonatologists or general pediatricians must judge whether surgery is indicated and transfer patients to a specialized hospital in a timely fashion as required. Thus, we tested the hypothesis that increased NT-proBNP levels predict short-term outcomes in neonates with congenital heart diseases (CHDs) and are thus a useful tool for evaluating clinical status and guiding treatment. Subjects were term or near-term newborns (≥36 weeks' gestation) with CHDs confined to left-to-right shunt lesions. Clinical parameters and NT-proBNP levels were measured on the first 7, 14, 21, and 28 days of life (DOL). We divided patients into a surgical (n = 7) and a conservative-treatment group (n = 21), and then compared clinical variables and outcomes between the groups. In the surgical group, NT-proBNP levels had a tendency to increase during the first 14 postnatal days and were significantly greater than in the conservative-treatment group on 7 DOL [median (range), 13,983 pg/mL (4,732-26,524) vs. 1,954 pg/mL (671-10,881); p = 0.0028] and on 14 DOL [29,274 pg/mL (14,006-33,740) vs. 2,050 pg/mL (1,304-9,250); p = 0.0055]. In contrast, NT-proBNP levels tended to decrease sequentially in the conservative-treatment group. The values of additional markers, such as mean NT-proBNP level on 7 and 14 DOLs (M7-14) and NT-proBNP level on 14 DOL minus that on 7 DOL (Δ7-14), were both significantly greater in the surgical group than in the conservative-treatment group. To examine the usability of M7-14 and Δ7-14 when the difference and mean cut-off levels were set at 10,000 and 3,000 pg/mL, respectively, the sensitivity and specificity were both 100 %. In neonates who had CHDs with left-to-right shunt, analysis of the association between clinical variables and short-term outcomes showed that NT-proBNP, especially M7-14 and Δ7-14, is a useful predictor of early surgery.

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Biochemical markers of neonatal myocardial dysfunction

Cited by 20 publications

References 29 publications

Total Creatine Kinase and Its Isoenzymes in Cord Blood of Full Term Newborns

Total Creatine Kinase and Its Isoenzymes in Cord Blood of Full Term Newborns

The Influence of Age on Serum Concentrations of Cardiac Troponin I

N-Terminal Pro-Brain Natriuretic Peptide As a Useful Predictor of Early Surgery in Neonates With Congenital Heart Diseases: A Prospective Observational Study

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