Biochemical markers of psoriasis as a metabolic disease

Gerkowicz, Agnieszka; Pietrzak, Aldona; Szepietowski, Jacek C.; Radej, Sebastian; Chodorowska, Grażyna

doi:10.5603/fhc.2012.0025

Cited by 41 publications

(35 citation statements)

References 213 publications

(308 reference statements)

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“…Significantly high HOMA-IR value compared between subjects with and without psoriasis vulgaris is also related to chronic inflammation as the underlying pathogenesis. 13 This study presented positive correlation among psoriasis vulgaris severity index and HOMA-IR value (r=0.427; p<0.05). This result gives answer to the study hypothesis in which there is a significantly positive correlation between psoriasis vulgaris severity index and HOMA-IR values.…”

Section: Discussionmentioning

confidence: 49%

Positive correlation of psoriasis vulgaris severity and HOMA-IR

Wardhana¹,

Adiguna²,

Nareswari³

2019

Bali Dermatology and Venereology Journal

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Background: Psoriasis vulgaris is a chronic inflammatory skin disease that its aetiology is still not completely known. A chronic inflammation in psoriasis can cause organ dysfunctions. Elevation of proinflammatory cytokines gives rise to insulin resistance by inhibiting insulin and glucose transport mechanism signals. Insulin resistance is the underlying pathogenesis of metabolic syndrome.Objective: This study aimed to undestand any correlation in the severity of psoriasis vulgaris with HOMA-IR.Methods: A cross sectional research involving 35 subjects with psoriasis vulgaris and 15 subjects without who met the selection criteria. HOMA-IR is a formula used to measure insulin resistance which calculates the fasting insulin value in μU/ml x fasting glucose in mg/DL/405 taken from the blood veins of subjects. PASI score was used to determine psoriasis vulgaris severity.Results: This study shows that the HOMA-IR median value was higher in psoriasis subject than the subjects without psoriasis (p<0.05). The correlaton analysis shows a moderate positive correlation between psoriasis vulgaris severity and HOMA-IR (r= 0.427; p<0.05). The prevalence ratio was 8.57, which means psoriasis vulgaris subjects were 8.57 times more likely to have HOMA-IR compared to those without psoriasis vulgaris (p<0.05; 95%CI: 1.26-58.1).Conclusion: This study concludes that there is a moderate positive correlation between severity of psoriasis vulgaris and HOMA-IR values.

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Section: Discussionmentioning

confidence: 49%

Positive correlation of psoriasis vulgaris severity and HOMA-IR

Wardhana¹,

Adiguna²,

Nareswari³

2019

Bali Dermatology and Venereology Journal

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“…The results of previous studies unambiguously confirm the correlation between the TNF-α in serum and the intensity of skin lesions. The results of studies on the concentration of IL-17 are IL-23 are ambiguous – some of them indicate a strong correlation between the severity of the disease and the level of circulating interleukins, however, there are reports where the evaluated cytokines were indeterminable despite the advancement of the disease [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The level of proinflammatory cytokines: interleukins 12, 23, 17 and tumor necrosis factor  in patients with metabolic syndrome accompanying severe psoriasis and psoriatic arthritis

Pirowska¹,

Obtułowicz²,

Lipko-Godlewska³

et al. 2018

pdia

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IntroductionThe incidence of metabolic syndrome is estimated at 15–24% in the general population and at 30–50% in patients with psoriasis. A probable cause of the described correlation is a constant release in chronic dermatosis of proinflammatory cytokines and their influence on individual systems and organs.AimAssessment of the concentration of the proinflammatory cytokines (IL-12, IL-23, IL-17 and TNF-α) in blood serum and their correlation with the intensity of skin lesions, the presence of psoriatic arthritis and the risk of development of obesity and metabolic syndrome.Material and methodsThe concentrations of subunit p70 IL-12, IL-17 and IL-23, and TNF-α in subjects with psoriasis and metabolic syndrome were determined.ResultsThe level of the studied cytokines, IL-17, IL-23 and TNF-α was higher in patients diagnosed with psoriasis. Higher levels of IL-17, IL-23 and TNF-α were observed in patients with metabolic syndrome accompanying psoriasis. A higher level of IL-17 and IL-23 was found in sera of patients with psoriatic arthritis in comparison to normal psoriasis.ConclusionsIn the study, a higher level of IL-17 and IL-23 was also shown in patients with psoriatic arthritis in comparison to patients with normal psoriasis. The effectiveness of anti-IL12/23 drugs in psoriatic arthritis is a confirmation of the obtained results of the studies. Additionally, the increased level of IL-17, both in patients with metabolic syndrome and with psoriasis, could indirectly indicate an increased cardiovascular risk in patients with affected joints in comparison to psoriasis affecting only the skin.

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“…In several skin disorders, including scleroderma [26], dermatomyositis [27] and psoriasis [28], dermal adiponectin expression has been reported to be lower than in normal skin. Adiponectin expression is also suppressed by morphological changes of the dermis related to abnormal and excessive lipid accumulation, such as cellulite [29] and type 2 diabetes [30].…”

Section: Discussionmentioning

confidence: 99%