Biochemical, Molecular, Pharmacokinetic, and Toxicological Aspects of Dietary Polyphenols

Rasmi, Yousef; Silva, Aline Priscilla Gomes da; Rezaei, Sahar; Rafique, Safa; Ahmed, Muhammad Zeeshan

doi:10.1201/9781003251538-2

Cited by 4 publications

(3 citation statements)

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Section: Mechanisms Of Neuroprotective Effects Of T Pratense and Its ...mentioning

confidence: 99%

“…High oxygen consumption, relatively low levels of antioxidants, and low regenerative capacity result in brain tissue being susceptible to oxidative damage(Bhatt et al, 2020). It is well-known that polyphenolic compounds are responsible for the potential antioxidant activity and free radical scavenging capacity of isoflavone-rich plant foodstuffs(Rasmi et al, 2022).There are Different studies illustrated that neurodegenerations can be ameliorated upon phytoestrogens-isoflavone intake as a source of natural antioxidants which prevent oxidation of proteins, and lipid peroxidation and prevent the generation of ROS through strengthening the endogenous antioxidant defenses. Some of these phytoestrogens activate the nuclear factor erythroid 2-related factor 2 (NRF2) and its gene targets, which are regulated by antioxidant response element (ARE).…”

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confidence: 99%

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Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

Al‐Shami

Essawy

Elkader

2023

Phytotherapy Research

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Neurodegenerative disorders are heterogeneous, debilitating, and incurable groups of brain disorders that have common features including progressive degeneration of the structure and function of the nervous system. Phytoestogenic‐isoflavones have been identified as active compounds that can modulate different molecular signaling pathways related to the nervous system. The main aim is to shed the light on the molecular mechanisms followed by phytoestrogen‐isoflavones profound in the Trifolium pratense and discuss the latest pharmacological findings in the treatment of neurodegenerative disorders. Data were collected using different databases. The search terms used included “Phytoestrogens,” “Isoflavones,” “neurodegenerative disorders,” “Neuronal plasticity,” etc., and combinations of these keywords. As a result, this review article mainly demonstrates the potential neuroprotective properties of phystoestrogen‐isoflavones present in the Trifolium pratense (Red clover), particularly in neurodegenerative disorders. Phytochemical studies have shown that Trifolium pratense mainly includes more than 30 isoflavone compounds. Among them, phytoestrogen‐isoflavones, such as biochanin A, daidzein, formononetin, genistein (Gen), etc.,are characterized by potent neuroprotective properties against different neurodegenerative disorders. There are preclinical and clinical scientific evidence on their mechanisms of action involve molecular interaction with estrogenic receptors, anti‐inflammatory, anti‐oxidative, antiapoptotic, autophagic inducing, and so on. phytoestrogen‐isoflavones are the major bioactive components in the Trifolium pratense that exhibit therapeutic efficacy in the case of neurodegenerative disorders. This review provides detailed molecular mechanisms targeted by phytoestrogen‐isoflavones and experimental key findings for the clinical use of prescriptions containing Trifolium pratense‐derived isoflavones for the treatment of neurodegenerative disorders.

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Section: Mechanisms Of Neuroprotective Effects Of T Pratense and Its ...mentioning

confidence: 99%

mentioning

confidence: 99%

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

Al‐Shami

Essawy

Elkader

2023

Phytotherapy Research

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“…Furthermore, the interaction of polyphenols with the gut microbiota emerges as a key mechanism through which these compounds exert their health benefits. This highlights the importance of their bioavailability and bioaccessibility in optimizing their positive effects on human health [ 3 , 9 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy

El Oirdi

2024

Pharmaceuticals

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There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in a broad range of characteristics and biological effects. Polyphenols can be found in a variety of foods and drinks, including fruits, cereals, tea, and coffee. Studies both in vitro and in vivo, as well as clinical trials, have shown that they possess potent antioxidant activities, numerous therapeutic effects, and health advantages. Dietary polyphenols have demonstrated the potential to prevent many health problems, including obesity, atherosclerosis, high blood sugar, diabetes, hypertension, cancer, and neurological diseases. In this paper, the protective effects of polyphenols and the mechanisms behind them are investigated in detail, citing the most recent available literature. This review aims to provide a comprehensive overview of the current knowledge on the role of polyphenols in preventing and managing chronic diseases. The cited publications are derived from in vitro, in vivo, and human-based studies and clinical trials. A more complete understanding of these naturally occurring metabolites will pave the way for the development of novel polyphenol-rich diet and drug development programs. This, in turn, provides further evidence of their health benefits.

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A comprehensive review of the classification, sources, biosynthesis, and biological properties of hydroxybenzoic and hydroxycinnamic acids

da Silva,

Sganzerla,

John

et al. 2023

Phytochem Rev

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Biochemical, Molecular, Pharmacokinetic, and Toxicological Aspects of Dietary Polyphenols

Cited by 4 publications

References 0 publications

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy

A comprehensive review of the classification, sources, biosynthesis, and biological properties of hydroxybenzoic and hydroxycinnamic acids

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