Biochemical parameters and oxidative stress markers in Tunisian patients with periodontal disease

Gharbi, Ahmed; Hamila, Ali; Bouguezzi, Adel; Dandana, A.; Ferchichi, Salima; Chandad, Fatiha; Guezguez, Leila; Miled, A.

doi:10.1186/s12903-019-0912-4

Cited by 31 publications

(30 citation statements)

References 24 publications

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“…It was significantly decreased (P < 0.001) in the salivary and serum samples [Figures 1 and 3]. These results are in harmony with those recorded by Gharbi et al, 19 and Thomas et al, 20 In contrast, an article conducted by Panjamurthy et al 18 observed the high levels of catalase and SOD antioxidants in periodontitis. Glutathione is an example of thiol-containing peptides antioxidants.…”

Section: Conflicts Of Interestsupporting

confidence: 76%

Comparison of Some Indicators in Serum and Saliva on Periodontitis

Yousif,

Ismail,

Ismail

et al. 2021

Iraq Med J

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To assess the serum indicators level in healthy and periodontitis subjects and correlate the levels in the terms of changes of serum and salivary parameters in periodontal disease. Methods: The assay comprised 85 subjects, enrolled of both genders in the age range of 33-56 years old. Volunteers were categorized into two groups: 40 healthy individual, other groups (periodontal disease) embraced 45 patients. The salivary and blood samples were collected and sent for biochemical analysis to measure the nitric oxide (NO), superoxide dismutase (SOD), glutathione, catalase, Interleukin 6 (IL-6), Interleukin 4 (IL-4), and interferon-γ (IFN-γ) levels in periodontitis patients. Results: Based on the statistical evaluation of bio-indicator parameters, the following conclusion can be shown from this revision: Serum and saliva SOD (P < 0.001), glutathione (P < 0.001), and catalase (P < 0.001) activates were significantly reduced in periodontitis as compared with control groups, the remaining biochemical assessed in periodontitis patients [NO (P < 0.001), IL-4 (P < 0.0001), IL-6 (P < 0.0001), and IFN-γ (P < 0.0001)] indicated significantly high levels in both serum and saliva samples. Conclusions: The NO, SOD, catalase, glutathione and cytokines may be used as bio-indicator for periodontitis exposure, medical conduct and severity. This recognition offers early diagnosis of disease and progression. Also there was a direct positive correlation between the salivary and the serum bio-markers levels, which it was proved that the salivary non-invasive examination had a significant association with the serum investigation.

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Section: Conflicts Of Interestsupporting

confidence: 76%

Comparison of Some Indicators in Serum and Saliva on Periodontitis

Yousif,

Ismail,

Ismail

et al. 2021

Iraq Med J

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“…Lipid peroxidation degradation products such as malondialdehyde (MDA) and 4‐hydroxy‐2‐nonenal (4‐HNE) are detectable in biological fluids and indicate a pro‐oxidant state 6 . Increase in ROS levels cause oxidative stress 7 . Many salivary oxidative stress biomarkers can potentially be useful for screening of periodontal disease 8 .…”

Section: Introductionmentioning

confidence: 99%

Salivary and serum oxidative stress biomarkers and advanced glycation end products in periodontitis patients with or without diabetes: A cross‐sectional study

Altıngöz

Kurgan

Önder

et al. 2021

Journal of Periodontology

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Background Non‐invasive methods for periodontitis diagnosis would be a clinically important tool. This cross‐sectional study aimed to investigate the association between oxidative stress, glycation, and inflammation markers and periodontal clinical parameters in periodontitis and periodontally healthy patients with type 2 diabetes and corresponding systemically healthy controls. Methods Sixty‐seven periodontally healthy (DM‐H, n = 32) and periodontitis (DM‐P, n = 35) patients with type 2 diabetes, and 54 systemically healthy periodontitis (H‐P, n = 26) and periodontally healthy (H‐H, n = 28) controls were included. Clinical periodontal parameters, body mass index, fasting glucose, hemoglobin A1c (HbA1c), along with saliva and serum 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG), malondialdehyde (MDA), 4‐hydroxy‐2‐nonenal (4‐HNE), advanced glycation end products (AGE), AGE receptor (RAGE) and high sensitivity C‐reactive protein (hsCRP) levels were recorded and analyzed. Results Salivary 8‐OHdG levels were significantly higher in periodontitis compared to periodontally healthy patients, regardless of systemic status (P < 0.001). Salivary MDA levels were significantly higher in all disease groups compared to H‐H group (P ≤ 0.004). Serum AGE levels were significantly higher in diabetic groups than systemically healthy groups (P < 0.001) and in H‐P compared to H‐H (P < 0.001). Bleeding on probing (BOP) and clinical attachment level (CAL) strongly correlated with salivary 8‐OHdG and serum hsCRP (P < 0.001). In systemically healthy patients, salivary 8‐OHdG was the most accurate marker to differentiate periodontitis from controls (AUC = 0.84). In diabetics salivary 4‐HNE and RAGE were the most accurate (AUC = 0.85 for both). Conclusion Salivary 8‐OHdG alone or in combination with 4‐HNE, AGE and RAGE for diabetics, and salivary 8‐OHdG alone or in combination with MDA and hsCRP for systemically healthy persons, could potentially serve as non‐invasive screening marker(s) of periodontitis.

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“…Although there is no clear explanation for the role of oxidative stress markers in the progression of periodontal diseases, studies are showing that the increase of oxidative stress products impairs periodontal regeneration or healing. Many studies have also reported that these oxidative stress products are associated with osteoclastic bone resorption and can induce the destruction of periodontal tissues (34). Besides, measuring oxidants individually is not only a practical method; but also it is a cheaper method to use the total oxidative status (TOS) and total antioxidant capacity (TAOC) measurement method (35).…”

Section: Discussionmentioning

confidence: 99%

Photobiomodulation Therapy by 820 nm Diode Laser on Nonsurgical Periodontal Treatment of Smoker and Nonsmoker Patients: A Single‐Blind Parallel Randomized Clinical Trial

Özdemir

Gündoğar

Akpınar

2021

Photochem & Photobiology

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The effect of smoking on nonsurgical periodontal treatment (SRP) is known, but the adjunct use of photobiomodulation (PBMT) to SRP has not been fully investigated in smokers. This study aimed to assess the effect of 820 nm diode laser on SRP in smoker/nonsmoker. Sixty patients (smokers/n = 30, nonsmokers/n = 30) were enrolled in this parallel‐arm clinical study. All patients were divided into two main groups: SRP and PBMT + SRP. In PMBT + SRP groups, 7.96 J cm−2 energy was applied by 820nm diode laser at baseline and first, second and third weeks after SRP. Periodontal pocket depth (PPD), gingival index (GI), plaque index (PI) and clinical attachment level (CAL) were recorded, and also gingival crevicular fluid (GCF) samples were collected at baseline and 6w after SRP. Total antioxidant capacity (TAOC) and total oxidative status (TOS) in GCF were analyzed. PBMT + SRP groups showed a statistically significant decrease in PPD and CAL, not in GI and PI compared with SRP alone. There were no statistically significant differences between smokers and nonsmokers in clinical data at six weeks after treatment. Although TAOC levels were increased in PMBT groups, TOS levels were decreased in all groups at the comparison of baseline and 6w after SRP. Adjunct use of 820 nm diode laser on SRP may improve the clinical parameters in smoker or nonsmoker patient with periodontitis.

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Biochemical parameters and oxidative stress markers in Tunisian patients with periodontal disease

Cited by 31 publications

References 24 publications

Comparison of Some Indicators in Serum and Saliva on Periodontitis

Comparison of Some Indicators in Serum and Saliva on Periodontitis

Salivary and serum oxidative stress biomarkers and advanced glycation end products in periodontitis patients with or without diabetes: A cross‐sectional study

Photobiomodulation Therapy by 820 nm Diode Laser on Nonsurgical Periodontal Treatment of Smoker and Nonsmoker Patients: A Single‐Blind Parallel Randomized Clinical Trial

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