Biochemical parameters as indicators of antihypertensive efficacy of leaf aqueous extract of Tridax procumbens (Lin) in L-NAME induced hypertensive rats

Abstract

Background: Cardiovascular disease is a widespread public health problem and hypertension is one of the major risk factors of it. Tridax procumbens leaf extract is traditionally used in the treatment of hypertension. This study evaluates the effects of T. procumbens extract (TPE) on blood biochemical parameters of N-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats. Materials and Methods: Rats were divided randomly into four different treatment groups. Group I received 0.9% NaCl (control), Group II, III, and IV were given a nitric oxide synthase inhibitor (L-NAME) 40 mg/kg/day, orally for 6 weeks to induce hypertension. Groups III and IV were further treated with TPE (100 and 200 mg/kg/day), respectively, in the past 3 weeks of 6 weeks. Blood pressure, morphological variables, histopathology, plasma lipids, lipoproteins, cholesterol levels, hepatic enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), and other parameters were analyzed. Results: TPE markedly inhibited the sustenance of L-NAME-induced hypertension. This effect was accompanied by a partial or full amelioration of most of the adverse effects induced by L-NAME, such as: (1) Increases in blood pressure, organs weight indices; (2) hyperlipidemia; (3) increased plasma activity of glutamic-pyruvic transaminase (ALT) and AST; and (4) liver and cardiac histological lesions. Conclusions: This study provides evidence about the antihypertensive effects and end-organ protection of TPE in animal model of hypertension. These effects may be due to one or more constitution in this extract.

Tridax procumbens leaf antioxidants and hormonal activity ameliorate variable stress-induced erectile and reproductive impairments in Wistar rats

“…Furthermore, superoxide dismutase concentration was reduced in the CVS-only exposed group as compared to the EETP supplemented group (Table 1). Similar protective activity of EETP, as observed in this study, has been previously suggested by other studies 13,22 . A recent study also reported a similar observation regarding vitamin C supplementation (alone) during CVS exposure 13,14 in male and gravid female rats.…”

A Mini Review on Some Known Medicinal Uses of Tridax procumbens

“…According to the aforementioned findings, mechanisms depending on or unrelated to the endothelium are presumably what help the T. procumbens extract's vasorelaxant impact. Salahdeen et al 22 experimented to evaluate parameters used to determine the efficiency of aqueous leaf extract of Tridax procumbens (Linn.) in managing hypertension.…”

Mechanisms in Tridax procumbens leaf extract reversal of paroxetine-induced erectile dysfunction in corpus cavernosum of male Wistar rats

“…Furthermore, a mechanistic study by Salahdeen et al 6 observed that the stimulation of prostacyclin production and opening of small conductance calciumactivated potassium channels are involved in the vasorelaxant activities of AETPL in normotensive rats. In hypertensive rats, treatment with AETPL significantly reduced arterial blood pressure in Nitric Oxide (NO) synthase inhibitor (L-NAME)-induced hypertensive male rats 7 . The ability of the Tridax procumbens leaf extract to significantly reduce arterial blood pressure in hypertensive rats opened a vista in the mechanistic study of the vasorelaxant activities of AETPL.…”