Biochemical Processes Related to Insecticide Action: an Overview

Ishaaya, I.

doi:10.1007/978-3-642-59549-3_1

Cited by 31 publications

(29 citation statements)

References 104 publications

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“…Hydrolytic enzymes constitute a large family of enzymes commonly involved in resistance to a number of insecticide classes, especially the organophosphates 75. Such a mechanism of enhanced hydrolysis (probably involving an esterase) was recently described in field strains of Venturia inaequalis (Cooke) Winter resistant to kresoxim‐methyl; this phenomenon could also contribute to the natural resistance of B cinerea towards this strobilurin 76.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of resistance to fungicides in field strains of Botrytis cinerea

Leroux

Fritz

Debieu

et al. 2002

Pest Management Science

420

279

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Field strains of Botrytis cinerea Pers ex Fr, the causal agent of grey mould diseases, were collected from French vineyards between 1993 and 2000. Several phenotypes have been characterized according to the inhibitory effects of fungicides towards germ-tube elongation and mycelial growth. Two types of benzimidazole-resistant strains (Ben R1 and Ben R2) could be detected; negative cross-resistance to phenylcarbamates (e.g. diethofencarb) was only found in Ben R1. Benzimidazole resistance was related to point mutations at codon 198 (Ben R1) or 200 (Ben R2) of the beta-tubulin gene. Most dicarboximide-resistant strains were also weakly resistant to aromatic hydrocarbon fungicides (e.g. dicloran) but remained sensitive to phenylpyrroles (e.g. fludioxonil). These resistant field strains (Imi R1) contained a single base pair mutation at position 365 in a two-component histidine kinase gene, probably involved in the fungal osmoregulation. Three anilinopyrimidine-resistant phenotypes have been identified. In the most resistant one (Ani R1), resistance was restricted to anilinopyrimidines, but no differences were observed in the amino-acid sequences of cystathionine beta-lyase (the potential target site of these fungicides) from Ani R1 or wild-type strains. In the two other phenotypes (Ani R2 and Ani R3), resistance extended to various other groups of fungicide, including dicarboximides, phenylpyrroles and sterol biosynthesis inhibitors. This multi-drug resistance was probably determined by over-production of ATP-binding cassette transporters. The hydroxyanilide fenhexamid is a novel botryticide whose primary target site is the 3-keto reductase involved in sterol C-4 demethylations. Apart from the multi-drug-resistant strain Ani R3, three other fenhexamid-resistant phenotypes have been recognized. For two of them (Hyd R1 and Hyd R2) fenhexamid-resistance seemed to result from P450-mediated detoxification. Reduced sensitivity of the target site could be the putative resistance mechanism operating in the third resistant phenotype (Hyd R3). Increased sensitivity to inhibitors of sterol 14 alpha-demethylase recorded in Hyd R1 strains was related to two amino-acid changes at positions 15 and 105 of this enzyme.

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Section: Discussionmentioning

confidence: 99%

Mechanisms of resistance to fungicides in field strains of Botrytis cinerea

Leroux

Fritz

Debieu

et al. 2002

Pest Management Science

420

279

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“…Diafenthiuron (Pegasus) is a new type of thiourea derivative that affects respiration in insects. It disrupts oxidative phosphorylation by inhibition of the mitochondrial ATP synthase, an enzyme with essential role in cellular bioenergetics (Ishaaya, 2010). It is an insecticide and acaricide which kills larvae, nymphs and adults by contact and/or stomach action, showing also some ovicidal action (e-pesticide manual, 2005).…”

Section: Discussionmentioning

confidence: 99%

Management of Tuta absoluta (Lepidoptera, Gelechiidae) with Insecticides on Tomatoes

Braham¹,

Hajji²

2012

Insecticides - Pest Engineering

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“…During the past two decades, many investigations have been directed towards elucidating the possible use of ecdysteroids and juvenile hormone receptors as target sites for developing novel insecticides. Several substituted dibenzoyl hydrazines that act as ecdysone agonists have been synthesized, such as tebufenoside, methoxyfenoside and halofenozide, and used for controlling lepidopteran and coleopteran pests (Ishaaya 2001).…”

Section: Insect Growth Regulatorsmentioning

confidence: 99%

“…It acts by both ingestion and contact. It is a powerful suppressor of lepidopteran larvae such as Spodoptera littoralis , S. exigua , S. frugiperda , Helicoverpa armigera and Tuta absoluta , species known to attack cotton, corn and vegetables (Ishaaya 2001). It also efficiently controls the whiteflies Bemisia tabaci and Trialeurodes vaporariorum and the leaf miners Liriomyza huidobrensis and Perileucoptera cofeella (Ishaaya et al .…”

Section: Insect Growth Regulatorsmentioning

confidence: 99%

Insecticides with novel modes of action: Mechanism, selectivity and cross‐resistance

Ishaaya

Barazani

Kontsedalov

et al. 2007

Entomological Research

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Efforts have been made during the past two decades to develop insecticides with selective properties that act specifically on biochemical sites present in particular insect groups, but whose properties differ from other insecticides. This approach has led to the discovery of compounds that affect the hormonal regulation of molting and developmental processes in insects; for example, ecdysone agonists, juvenile hormone mimics and chitin synthesis inhibitors. In addition, compounds that selectively interact with the insect nicotinic acetylcholine receptor, such as imidacloprid, acetamiprid and thiamethoxam, have been introduced for the control of aphids, whiteflies and other insect species. Natural products acting selectively on insect pests, such as avermectins, spinosad and azadirachtin, have been introduced for controlling selected groups of insect pests. Compounds acting on the nervous site that controls the sucking pump of aphids and whiteflies, such as pymetrozine, or respiration, such as diafenthiuron, have been introduced for controlling sucking pests. All the above compounds are important components in pest and resistance management programs.

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Biochemical Processes Related to Insecticide Action: an Overview

Cited by 31 publications

References 104 publications

Mechanisms of resistance to fungicides in field strains of Botrytis cinerea

Mechanisms of resistance to fungicides in field strains of Botrytis cinerea

Management of Tuta absoluta (Lepidoptera, Gelechiidae) with Insecticides on Tomatoes

Insecticides with novel modes of action: Mechanism, selectivity and cross‐resistance

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