Biochemical profile, eating habits, and telomere length among Brazilian children and adolescents

Associations of telomere length with two dietary quality indices after a lifestyle intervention in children with abdominal obesity: a randomized controlled trial

“…This study demonstrates the beneficial effects of a lifestyle intervention in paediatric subjects with obesity, in line with studies performed in children and adolescents with a similar age range 6‐17 included in two Cochrane systematic reviews 44,45 . It is worth to highlighting that a decrease of more than 0.25 in BMI‐SDS did reduce cardiovascular risk factors 46 .…”

“…Furthermore, modifiable factors such as diet quality and healthy lifestyle could be important factors for telomere integrity 12‐15 . Three cross‐sectional studies have evaluated the relationship between dietary intake and TL in paediatric population 16‐18 . García‐Calzón et al showed that a higher dietary total antioxidant capacity, related to increased consumption of polyunsaturated fatty acids, legumes and lower total cereal intake, was associated with longer TL in Spanish children (with obesity, overweight and normal weight) 16 .…”

“…García‐Calzón et al showed that a higher dietary total antioxidant capacity, related to increased consumption of polyunsaturated fatty acids, legumes and lower total cereal intake, was associated with longer TL in Spanish children (with obesity, overweight and normal weight) 16 . In Brazilian children (with obesity, overweight, normal weight and underweight), only consumption of fruit and vegetables was associated with longer TL 17 . In contrast, in Georgian adolescents (affected by overweight or obesity), higher sodium intake was associated with shorter TL 18 .…”

Systematic review and meta‐analysis of the association between paediatric obesity and telomere length

“…24,25 The age ranged from 0.5 to 18 years, and the percentage of boys was between 44.0% and 53.9% (Table 1). The majority of the included studies (10/11) used quantitative real-time polymerase chain reaction (qPCR) method to evaluate telomere length, [22][23][24][25][26][27][28]31,34,35 while one study applied the terminal restriction fragmentation method 29 (Table 2). Most studies (6/11) measured telomere length from leukocytes.…”

“…We further excluded four papers that reported results for a mixed population of children and adults, six papers that treated obesity neither as the exposure nor as the outcome, and one duplicated paper. Finally, 11 papers were included in the systematic review, [22][23][24][25][26][27][28][29]31,34,35 and seven papers 24,[26][27][28][29]34,35 were synthesised in the meta-analysis.…”