Biochemical profile of rumen liquor, blood and urine in experimental acidosis in sheep

Patra, R C; Lal, Sardari; Swarup, D.

doi:10.1016/0921-4488(95)00743-1

Cited by 31 publications

(24 citation statements)

References 12 publications

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“…Similar results had been reported previously (Patra et al, 1996;Kirbas et al, 2014). Binding of endotoxins to cellular membrane receptors initiate inflammation and cytokines procuction, which lead to hepatic dysfunction and increase in AST activity.…”

Section: Resultssupporting

confidence: 82%

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Evaluation of serum cardiac biomarkers in sheep with acute lactic acidosis

Fartashvand

Hajisadeghi

2018

J Hellenic Vet Med Soc

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In this study we investigated the changes of cardiac injury biomarkers in serum samples from 200 sheep with acute ruminal lactic acidosis (ARLA) and 50 healthy controls belonging to the Ghezel breed. After clinical examination and recording of vital signs (heart rate, respiratory rate, rectal temperature and hydration status), rumen fluid and venous blood samples were collected. The pH of rumen fluid was determined using a paper tape pH-meter and lactic acid concentration of serum was measured using a commercially available method. Similarly, activities of AST, LDH, CK-MB and serum concentration of cTnI were measured using special commercial kits. According to the findings serum activities of AST (p = 0.007) and CK-MB (p = 0.002) in sheep with ARLA were significantly higher than in healthy animals. Serum LDH activity in the disease group was higher than in the control group, however this difference was statistically non-significant. cTnI concentration were 0.684 ± 0.03 ng/ml in sheep with ARLA, which was significantly higher than in healthy sheep (p = 0.000). There were significant negative correlations between ruminal pH and serum lactate levels, heart rate, respiratory rate and dehydration degree. The sheep with the lowest ruminal pH (3 cases with < 4.5) had the highest levels of cTnI (2.28 to 3.06 ng/mL), and all died. It can be concluded that lactic acidosis may cause some degree of heart damage, although further studies are needed to support this speculation.

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Section: Resultssupporting

confidence: 82%

“…Rapid fermentation of carbohydrates lead to production of lactic acid and a decrease in ruminal pH to physiologically inappropriate levels and finally metabolic acidosis occurs (Patra et al, 1996;JafariDehkordi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum cardiac biomarkers in sheep with acute lactic acidosis

Fartashvand

Hajisadeghi

2018

J Hellenic Vet Med Soc

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“…Esse resultado exigiu a administração oral de solução saturada de bicarbonato de sódio (50 g/100 mL de água/animal) durante três dias consecutivos e inclusão desse tamponante na formulação do concentrado. Patra et al (1996) provocaram acidose em ovelhas por excesso de amido e verificaram que o pH do rúmen decresceu de 6,75 para 4,91 e 4,70 e que a concentração de ácido lático no líquido ruminal elevou de 0,312 para 17,73 e 26,268 mmol/ dL e a de ácido lático no sangue, de 1,29 para 4,26 e 4,87 mmol/dL no tempo 0, 12 e 24 horas após a alimentação, respectivamente.…”

Section: Resultsunclassified

Efeito dos níveis de concentrado sobre o desempenho de ovinos Morada Nova em confinamento

Medeiros¹,

Carvalho

Ferreira

et al. 2007

R. Bras. Zootec.

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RESUMO - Effect of concentrate level on performance of feedlot Morada Nova sheepABSTRACT -The objective of this trial was to evaluate performance and nutrient intake and digestibility in feedlot Morada Nova hair sheep fed increasing levels of dietary concentrate. Thirty-two castratated Morada Nova sheep averaging 8.11 ± 1.15 months of age and 19.67 ± 2.97 kg of body weight (BW) at the beginning of the study were used in this trial. Animals were slaughtered with 30.0 kg of BW and fed diets with the following concentrate levels: 20, 40, 60 or 80%. A completely randomized block design with eight replicates per treatment was used. There was a significant linear reduction in feedlot days from 123.37 to 52.50 when the concentrate levels increased from 20 to 80% in the diet. Conversely, dry matter intake increasead linearly from 0.925 to 1.124 kg/day by reducing the forage:concentrate ratio of the diet. The daily weight gain and feed conversion and efficiency improved with increasing the levels concentrate in the diet. Intakes of organic matter, crude protein, ether extract, total digestible nutrients, metabolizable energy, total carbohydrates, and nonfiber carbohydrates all increasead with concentrate levels in the diet, while the opposite was observed for intakes of neutral detergent fiber and acid detergent fiber. Total tract apparent digestibility of dry matter, organic matter, and total carbohydrates increased when the concentrate levels was increased in the diet. Significant quadratic effects were observed for the the digestibility of ether extract and nonfiber carbohydrates while that of crude protein, neutral detergent fiber and acid detergent fibers was not affected by the dietary levels of concentrate. Dietary concentrate levels greater than 60% improved performance of feedlot Morada Nova sheep by increasing daily weight gain and decreasing slaughter feedlot time. Diets with concentrate levels higher than 40% increasead digestibility coefficients of nutrients.

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“…Elevated activities of amylase, creatinine phosphokinase and gamma glutamine trans-peptidase (GGTP) were revealed in serum enzyme profiles of acidotic sheep (Patra et al, 1996). The change in serum amylase may be attributed to change in carbohydrate metabolism (Kaneko, 1989) and lowering of rumen pH (Slyter, 1976).…”

Section: Biochemical Effects Of Acidosis On the Animalmentioning

confidence: 99%

“…Creatinine phosphokinase activity is one of the most specific indicators of muscle damage (Kaneko, 1989) and hence increased activity of this enzyme may be a signal to muscle damage in acidosis. Increased activity of GGTP, a liver-specific enzyme, reflects hepatobiliary damage (Patra et al, 1996).…”

Section: Biochemical Effects Of Acidosis On the Animalmentioning

confidence: 99%

Physiological, biochemical and histopathological effects of fermentative acidosis in ruminant production: a minimal review

Xu¹,

Ding²

2011

Span. j. agric. res.

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Rumen acidosis is increasingly recognized as a significant disorder in ruminants that increases the morbidity and mortality of animals, especially for dairy cattle and sheep. Acidosis is not just D-lactate which disturbs the acid-base status and the severity of acidosis is related to many factors and not only due to the level of lactic acid production, resulting in difficulties in diagnosing acidosis. Therefore, an understanding of the physiological, biochemical, and histopathological effects of rumen acidosis is fundamental for developing effective methods of prevention and treatment of fermentative acidosis. The present review evaluates the physiology, biochemistry, and pathophysiology of fermentative acidosis as well as gives a conclusion and look-forward. The information will benefit the health and welfare of ruminants and contribute to modern systems of ruminant production.

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Biochemical profile of rumen liquor, blood and urine in experimental acidosis in sheep

Cited by 31 publications

References 12 publications

Evaluation of serum cardiac biomarkers in sheep with acute lactic acidosis

Evaluation of serum cardiac biomarkers in sheep with acute lactic acidosis

Efeito dos níveis de concentrado sobre o desempenho de ovinos Morada Nova em confinamento

Physiological, biochemical and histopathological effects of fermentative acidosis in ruminant production: a minimal review

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