Biochemical responses in mice experimentally infected with Paracoccidioides brasiliensis and treated with Canova

Takahachi, Gisele; Maluf, Márcia Luzia Ferrarezi; Svidzinski, Terezinha Inez Estivalet; Akimoto-Gunther, Luciene; Hübler, Márcia Rosangela Neves de Oliveira; Bersani-Amado, Ciomar Aparecida; Cuman, Roberto Kenji Nakamura

doi:10.1590/s1516-89132006000700006

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…The liver can also be affected by this disease, and some studies show that liver enzymes are altered [21], [22] indicating that the infection can disrupt the homeostasis of this organ. However, there are no studies of the liver of animals infected with Pb using FT-Raman spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

“…The main organ affected by PCM is the lung, but can often affect other sites such as bone, skin, mucosa and lymphoid organs [2] , [3] , [20] . The liver can also be affected by this disease, and some studies show that liver enzymes are altered [21] , [22] indicating that the infection can disrupt the homeostasis of this organ. However, there are no studies of the liver of animals infected with Pb using FT-Raman spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Histopathological and FT-Raman Spectroscopy Analysis of the Liver of Swiss Mice Infected with Paracoccidioides brasiliensis

et al. 2014

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Paracoccidioidomycosis is the most important systemic mycosis in Latin America. The main entrance of the fungus is the airway. It primarily occurs in the lung, but in its disseminated form may affect any organ. The liver is one of the organs afflicted by this disease and its homeostasis may be impaired. The aim of the present study was to evaluate the evolution of paracoccidioidomycosis in the liver of Swiss mice and correlate morphological factors with the expression of gp43 and with physicochemical analysis via FT-Raman of the infected organ. According to colony forming unit (CFU) and granuloma counting, the first and second weeks were the periods when infection was most severe. Tissue response was characterized by the development of organized granulomas and widespread infection, with yeasts located within the macrophages and isolated hepatocytes. The gp43 molecule was distributed throughout the hepatic parenchyma, and immunostaining was constant in all observed periods. The main physicochemical changes of the infected liver were observed in the spectral ranges between 1700–1530 cm−1 and 1370 – 1290 cm−1, a peak shifting center attributed to phenylalanine and area variation of -CH2 and -CH3 compounds associated to collagen, respectively. Over time, there was a direct proportional relationship between the number of CFUs, the number of granulomas and the physicochemical changes in the liver of mice infected with Paracoccidioides brasiliensis. The expression of gp43 was similar in all observed periods.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation between Histopathological and FT-Raman Spectroscopy Analysis of the Liver of Swiss Mice Infected with Paracoccidioides brasiliensis

et al. 2014

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“…Biochemical features were assessed in mice models of Paracoccidioides under treatment with the compound canova, which is a natural compound extracted from Aconitum napellus and Arsenicum album . Mice treated with canova developed fewer functional alterations in organs affected by the pathogen [ 132 ].…”

Section: Models For In Vivo Experimentsmentioning

confidence: 99%

Overview of Antifungal Drugs against Paracoccidioidomycosis: How Do We Start, Where Are We, and Where Are We Going?

Silva

Oliveira

Souza

et al. 2020

JoF

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Paracoccidioidomycosis is a neglected disease that causes economic and social impacts, mainly affecting people of certain social segments, such as rural workers. The limitations of antifungals, such as toxicity, drug interactions, restricted routes of administration, and the reduced bioavailability in target tissues, have become evident in clinical settings. These factors, added to the fact that Paracoccidioidomycosis (PCM) therapy is a long process, lasting from months to years, emphasize the need for the research and development of new molecules. Researchers have concentrated efforts on the identification of new compounds using numerous tools and targeting important proteins from Paracoccidioides, with the emphasis on enzymatic pathways absent in humans. This review aims to discuss the aspects related to the identification of compounds, methodologies, and perspectives when proposing new antifungal agents against PCM.

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Canova medication changes TNF-α and IL-10 serum levels in mice infected with Trypanosoma cruzi Y strain

Pupulin

Bracht

Dalalio

et al. 2016

Asian Pacific Journal of Tropical Medicine

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Biochemical responses in mice experimentally infected with Paracoccidioides brasiliensis and treated with Canova

Abstract: ABSTRACT

Cited by 4 publications

References 9 publications

Correlation between Histopathological and FT-Raman Spectroscopy Analysis of the Liver of Swiss Mice Infected with Paracoccidioides brasiliensis

Correlation between Histopathological and FT-Raman Spectroscopy Analysis of the Liver of Swiss Mice Infected with Paracoccidioides brasiliensis

Overview of Antifungal Drugs against Paracoccidioidomycosis: How Do We Start, Where Are We, and Where Are We Going?

Canova medication changes TNF-α and IL-10 serum levels in mice infected with Trypanosoma cruzi Y strain

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